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Cutaneous biopsies and excisions constitute the most frequently performed procedures in surgical pathology, yet they present some of the most difficult diagnostic challenges. Through five authoritative editions, Weedon's Skin Pathology has earned outstanding reviews and accolades from practicing and trainee dermatopathologists, general pathologists, and dermatologists worldwide. The 6th Edition continues this tradition of excellence, helping you accurately and efficiently sign out complex skin cases in everyday practice, while also keeping you up to date with recent advances in the field. Dr. James W. Patterson’s single-author approach continues to provide clarity and consistency from cover to cover, resulting in what has been described as “the best reference text available in dermatopathology in the world” (Pathology).

Key Features

Provides comprehensive coverage of the full spectrum of dermatopathological entities, both inflammatory and neoplastic, highlighted by more than 1,800 color photomicrographs that illustrate the full range of pathologic appearances and help identify each diagnostic entity.

Helps you arrive at the most accurate diagnoses possible by demonstrating what is seen through the microscope and identifying the characteristic features of the lesion—for established disorders, unusual and rare disease entities, and incompletely defined entities.

Includes new information on molecular diagnostics throughout, including FISH (fluorescence in situ hybridization) techniques, plus new developments in molecular biology and molecular techniques, targeted-personalized medicine, and immunohistochemistry.

Contains more tables for quick reference, new figures that demonstrate key differential diagnostic points, and discussions of new entities, as well as thorough content updates in every section.

Includes practical advice on diagnostic pitfalls and how to avoid them to help minimize reporting errors, and diagnostic clues to assist both experienced and novice practitioners in formulating an accurate diagnosis.

Identifies both important articles and more rare and unusual reports with remarkably authoritative, comprehensive, current, and relevant reference lists (over 35,000) for each entity.

An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.


Author Information
By James W. Patterson, MD, FACP, FAAD, Professor Emeritus of Pathology, University of Virginia Health System, Charlottesville, VA, USA.




SECTION 1 Introduction
1 What’s new in the sixth edition
2 An approach to the interpretation of skin biopsies
3 Diagnostic clues

SECTION 2 Tissue reaction patterns
4 The lichenoid reaction pattern (“interface dermatitis”)
5 The psoriasiform reaction pattern
6 The spongiotic reaction pattern
7 The vesiculobullous reaction pattern
8 The granulomatous reaction pattern
9 The vasculopathic reaction pattern

SECTION 3 The epidermis
10 Disorders of epidermal maturation and keratinization
11 Disorders of pigmentation

SECTION 4 The dermis and subcutis
12 Disorders of collagen
13 Disorders of elastic tissue
14 Cutaneous mucinoses
15 Cutaneous deposits
16 Diseases of cutaneous appendages
17 Cysts, sinuses, and pits
18 Panniculitis

SECTION 5 The skin in systemic and miscellaneous diseases
19 Metabolic and storage diseases
20 Miscellaneous conditions
21 Cutaneous drug reactions
22 Reactions to physical agents

SECTION 6 Infections and infestations
23 Cutaneous infections and infestations--histological patterns
24 Bacterial and rickettsial infections
25 Spirochetal infections
26 Mycoses and algal infections
27 Viral diseases
28 Protozoal infections
29 Marine injuries
30 Helminth infestations
31 Arthropod-induced diseases

SECTION 7 Tumors
32 Tumors of the epidermis
33 Lentigines, nevi, and melanomas
34 Tumors of cutaneous appendages
35 Tumors and tumor-like proliferations of fibrous and related tissues
36 Tumors of fat
37 Tumors of muscle, cartilage, and bone
38 Neural and neuroendocrine tumors
39 Vascular tumors
40 Cutaneous metastases
41 Cutaneous infiltrates--nonlymphoid
42 Cutaneous infiltrates--lymphomatous and leukemic

Index