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The time-tested, most popular board prep resource―updated to reflect the newest Step 1 exam
First Aid for the USMLE Step 1 is a veritable blueprint for preparing for this critical exam, revealing all the content you will encounter on test day.
This unmatched text is written by carefully chosen students who excelled on the Step 1 exam and reviewed by top faculty―ensuring the content is relevant, high-yield, and accurate.
The book is organized and formatted in ways that help you easily hone in on the most important content.
The new edition of First Aid for the USMLE Step 1 is filled with 1,000 color clinical images, including more depicting diverse patients; 1,300+ high-yield facts and mnemonics, organized by basic principles and organ system; and invaluable test-taking advice.
There’s a reason for the longstanding success of First Aid for the USMLE Step 1. Once you open the 2025 edition, you’ll instantly understand why it’s a resource you can’t be without!
● SECTION I GUIDE TO EFFICIENT EXAM PREPARATION 1
Introduction 2
USMLE Step 1—The Basics 2
Learning Strategies 10
Timeline for Study 14
Study Materials 17
Test-Taking Strategies 20
Clinical Vignette Strategies 21
If You Think You Failed 22
Testing Agencies 23
References 23
● SECTION I SUPPLEMENT SPECIAL SITUATIONS 25
● SECTION II HIGH-YIELD GENERAL PRINCIPLES 27
How to Use the Database 28
Biochemistry 31
Immunology 93
Microbiology 121
● SECTION III HIGH-YIELD ORGAN SYSTEMS 279
Approaching the Organ Systems 280
Cardiovascular 283
Endocrine 329
Gastrointestinal 363
Hematology and Oncology 409
Musculoskeletal, Skin, and Connective Tissue 449
Neurology and Special Senses 499
Psychiatry 569
Renal 595
Reproductive 629
Respiratory 677
Rapid Review 707
● SECTION IV TOP-RATED REVIEW RESOURCES 739
How to Use the Database 740
Question Banks 742
Web and Mobile Apps 742
Comprehensive 743
Anatomy, Embryology, and Neuroscience 743
Behavioral Science 744
Biochemistry 744
Cell Biology and Histology 744
Microbiology and Immunology 744
Pathology 745
Pharmacology 745
Physiology 746
Abbreviations and Symbols 747
Image Acknowledgments 755
Index 773
About the Editors 844