Kaplan and Sadock's Comprehensive Textbook of Psychiatry-11판

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The gold standard reference for all those who work with people with mental illness, Kaplan & Sadock's Comprehensive Textbook of Psychiatry, edited by Drs. Robert Boland and Marcia L. Verduin, has consistently kept pace with the rapid growth of research and knowledge in neural science, as well as biological and psychological science.

This two-volume eleventh edition offers the expertise of more than 600 renowned contributors who cover the full range of psychiatry and mental health, including neural science, genetics, neuropsychiatry, psychopharmacology, and other key areas.

Provides comprehensive coverage of the full range of topics in psychiatry and mental health, keeping you at
the forefront of current developments in the field

Contains thoroughly updated and expanded content throughout, including the full range of psychiatric
therapeutics

Offers up-to-date coverage of neural sciences with sections on epigenetics, the microbiome, systems
neuroscience, the Human Connectome Project, neurodevelopment, and more

Includes “text within a text” coverage of child psychiatry with comprehensive information on neuroimaging,
assessment, genetics, sleep disorders, and the impact on parents of raising a psychiatrically disabled child

Contains abundant case histories that add clarity and represent the vast clinical experiences and wisdom of
hundreds of contributing authors

An indispensable resource for psychiatrists and other physicians, psychologists, psychiatric social workers,
psychiatric nurses, students, residents, and other mental health professionals.

VOLUME I

1 Neural Sciences

1.01 The Neuroscience of Psychiatry
1.02 Functional Neuroanatomy
1.03 Functional Genomics of Human Brain Development
1.04 Neural Development and Neurogenesis
1.05 Cellular and Synaptic Basis of Neural Signaling
1.06 Amino Acid Neurotransmitters
1.07 Biogenic Amine Neurotransmitters
1.08 Neuropeptides: Biology, Regulation and Role in Neuropsychiatric Disorders
1.09 Novel Neurotransmitters
1.10 Neurotrophic Factors
1.11 Intraneuronal Signaling
1.12 Psychoneuroendocrinology
1.13 Immune–Brain Interactions in Psychiatry
1.14 Chronobiology, Circadian Rhythm, and Psychiatry
1.15 Basic Science of Sleep
1.16 Pain Systems: Interface with Affective and Motivational Mechanisms
1.17 Basic Science of Appetite
1.18 Genome, Transcriptome, and Proteome: The Molecular Genetics, Biochemistry, and Multi-Omics Underlying the Neurobiology
1.19 Gene Mapping Investigations of Psychiatric Disorders
1.20 Epigenetics in Psychiatry: The Promise for New Biomarkers and Treatments
1.21 Pharmacogenetics
1.22 Animal Models in Psychiatry
1.23 Basic Systems Neuroscience
1.24 Computational Modeling Approaches to Psychiatry
1.25 Nuclear Magnetic Resonance Imaging and Spectroscopy: Basic Principles and Recent Findings in Neuropsychiatric Disorders
1.26 Electroencephalography in Psychiatry
1.27 Radiotracer Imaging with Positron Emission Tomography and Single Photon Emission Computed Tomography: Fundamental
1.28 Functional Brain Connectivity and Psychopathology
1.29 Neuropsychiatry of Self
1.30 Learning Theory and Psychosis, Anxiety, and Addiction
1.31 Neuroscience of Substance Use Disorders

2 Neuropsychiatry and Behavioral Neurology

2.01 The Neuropsychiatric Approach to the Patient
2.02 Neuropsychiatric Aspects of Cerebrovascular Disorders
2.03 The Neuropsychiatry of Brain Tumors
2.04 Neuropsychiatric Aspects of Epilepsy and Psychogenic Nonepileptic Seizures
2.05 Neuropsychiatric Consequences of Traumatic Brain Injury
2.06 Neuropsychiatric Aspects of Movement Disorders
2.07 Neuropsychiatric Aspects of Multiple Sclerosis and Other Demyelinating Disorders
2.08 Neuropsychiatric Aspects of HIV Infection and AIDS
2.09 Neuropsychiatric Aspects of Other Infectious Diseases (Non-HIV)
2.10 Neuropsychiatric Aspects of Prion Disease
2.11 Neuropsychiatric Aspects of Headache
2.12 Neuropsychiatric Aspects of Neuromuscular Diseases
2.13 Psychiatric Aspects of Child Neurology
2.14 Neuropsychiatry of Neurometabolic and Neuroendocrine Disorders
2.15 Catatonia

3 Contributions of the Psychological Sciences

3.01 Contributions of the Psychological Sciences: Sensation, Perception, and Cognition
3.02 Piaget and Cognitive Development: History, Theory, Extensions, and Modifications
3.03 Learning Theory
3.04 Biology of Memory
3.05 Normality and Mental Health
3.06 Neuroscience of Psychoanalytic Object Relations Theory

4 Contribution of the Social Sciences

4.01 Neurocentrism: Implications for Addiction and the Courtroom
4.02 Transcultural Psychiatry
4.03 Evolutionary Foundations for Psychiatric Research and Practice

5 Quantitative and Experimental Methods in Psychiatry

5.01 Quantitative and Experimental Methods in Psychiatry: Epidemiology
5.02 Statistics and Experimental Design

6 Theories of Personality and Psychopathology

6.01 Psychoanalytic Theories and Treatment: Perspective from North America and Great Britain
6.02 Erik H. Erikson
6.03 Other Psychodynamic Schools
6.04 Approaches Derived from Philosophy and Psychology

7 Diagnosis and Psychiatry: Examination of the Psychiatric Patient

7.01 Psychiatric Interview, History, and Mental Status Examination of the Adult Patient
7.02 The Psychiatric Report and Outline for a Psychiatric Examination
7.03 Practice Guidelines in Psychiatry
7.04 Neuropsychological Assessment of Adults
7.05 Personality Assessment of Adults
7.06 Medical Assessment and Laboratory Testing in Psychiatry
7.07 Principles and Applications of Quantitative Electroencephalography in Psychiatry
7.08 Psychiatric Rating Scales
7.09 Electronic Media in Psychiatry
7.10 Cultural Competency in the Organization and Delivery of Psychiatric Care
7.11 Medical Error

8 Clinical Manifestations of Psychiatric Disorders

9 Classification in Psychiatry

9.01 Present and Future of Classification Systems for Mental Disorders
9.02 The Classification of Mental Disorders in the International Classification of Diseases (ICD-11)

10 Neurocognitive Disorders

10.01 Cognitive Disorders: Introduction
10.02 Delirium
10.03 Major Neurocognitive Disorders (Dementia)
10.04 Mild Cognitive Impairment and Amnestic Disorders
10.05 Cognitive Disorders Due to Another Medical Condition or Substance

11 Substance-Related Disorders

11.01 Substance Use Disorders: Introduction
11.02 Alcohol-Related Disorders
11.03 Stimulant-Related Disorders
11.04 Caffeine-Related Disorders
11.05 Cannabis-Related Disorders
11.06 Hallucinogen-Related Disorders
11.07 Inhalant-Related Disorders
11.08 Tobacco-Related Disorders
11.09 Opioid Use and Related Disorders: From Neuroscience to Treatment
11.10 Sedative-, Hypnotic-, or Anxiolytic-Related Disorders
11.11 Anabolic-Androgenic Steroid-Related Disorders

12 Schizophrenia and Other Psychotic Disorders

12.01 Introduction and Overview
12.02 Phenomenology of Schizophrenia
12.03 Global Burden of Schizophrenia
12.04 Genetics of Schizophrenia
12.05 The Clinical Epidemiology of Psychosis Spectrum Disorder
12.06 Cellular and Molecular Neuropathology of Schizophrenia
12.07 Structural Brain Imaging in Schizophrenia
12.08 Functional Brain Imaging in Schizophrenia
12.09 Molecular Brain Imaging in Schizophrenia
12.10 Neurocognition in Schizophrenia
12.11 Phenotypes of Psychosis
12.12 Schizophrenia: Pharmacologic Treatment
12.13 Psychiatric Rehabilitation
12.14 Medical Health in Schizophrenia
12.15 Recovery in Schizophrenia
12.16 Psychosis as a Defining Dimension in Schizophrenia
12.17 Other Psychotic Disorders

13 Mood Disorders

13.01 Mood Disorders: Historical Introduction and Conceptual Overview
13.02 Mood Disorders: Epidemiology
13.03 Mood Disorders: Clinical Features
13.04 Mood Disorders: Intrapsychic and Interpersonal Aspects
13.05 Mood Disorders: Suicidal Behavior
13.06 Mood Disorders: Pharmacologic Treatment of Depression and Bipolar Disorders
13.07 Mood Disorders: Psychotherapy
13.08 Mood Disorders: Neurobiology

14 Anxiety Disorders

14.01 Anxiety Disorders: Introduction and Overview
14.02 Clinical Features of the Anxiety Disorders
14.03 Epidemiology of Anxiety Disorders
14.04 Anxiety Disorders: Neurobiology and Neuroscience
14.05 Neuroimaging and the Neuroanatomical Circuits Implicated in Anxiety Disorders
14.06 Anxiety Disorders: Cognitive-Behavioral Therapy
14.07 Somatic Therapies for Anxiety Disorders

15 Obsessive-Compulsive and Related Disorders

16 Pathological and Problem Gambling: Gambling Disorder

17 Post-Traumatic Stress Disorder

18 Somatic Symptom and Related Disorders

19 Factitious Disorder

20 Dissociative Disorders

21 Normal Sexuality and Sexual Disorders

21.01 Normal Human Sexuality and Sexual Dysfunctions
21.02 Homosexuality, Gay and Lesbian Identities, and Homosexual Behavior
21.03 Paraphilic Disorders
21.04 Gender Identity, Gender Diversity, Gender Dysphoria/Incongruence
21.05 Sexual Addiction

22 Feeding and Eating Disorders

23 Sleep Disorders

24 Impulse-Control Disorders

24.01 Intermittent Explosive Disorder
24.02 Pyromania
24.03 Kleptomania

25 Adjustment Disorders

26 Personality Disorders

VOLUME II

27 Consultation-Liaison Psychiatry and Psychosomatic Medicine

27.01 History and Current Trends
27.02 Cardiovascular Disorders
27.03 Gastrointestinal Disorders
27.04 Psychosomatic Medicine: Obesity
27.05 Respiratory Disorders
27.06 Diabetes: Psychosocial Issues and Psychiatric Disorders
27.07 Endocrine and Metabolic Disorders
27.08 Psycho-Oncology
27.09 End-of-Life and Palliative Care
27.10 Stress and Psychiatry
27.11 Psychiatric Morbidity Following Critical Illness
27.12 Psychocutaneous Disorder
27.13 Organ Transplantation
27.14 Psychiatric Care of the Burned Patient
27.15 Management of Chronic Pain

28 Additional Conditions That May Be a Focus of Clinical Attention

28.01 Malingering
28.02 Adult Antisocial Behavior, Criminality, and Violence
28.03 Borderline Intellectual Functioning and Academic or Educational Problem
28.04 Relational Problems

29 Cultural Concepts of Distress and Assessment

29.01 Cultural Concepts of Distress
29.02 Cultural Assessments in Psychiatry

30 Special Areas of Interest

30.01 Psychiatry and Reproductive Medicine
30.02 Genetic Counseling for Psychiatric Conditions
30.03 Physical Violence on Adults
30.04 Complementary, Alternative, and Integrative Approaches in Mental Health Care
30.05 Micronutrient Monitoring and Supplementation in Psychiatric Illness
30.06 Disaster Psychiatry: Disasters, Terrorism, and War
30.07 Psychiatry and Spirituality
30.08 Physician and Medical Student Mental Health
30.09 Computers in Psychiatry

31 Psychiatric Emergencies

31.01 Suicide: Overview of Epidemiology, Risk and Protective Factors, Treatment, and Prevention
31.02 Suicide Treatment
31.03 Other Psychiatric Emergencies

32 Psychotherapies

32.01 Psychotherapy Integration
32.02 Supportive Psychotherapy
32.03 Psychoanalysis and Psychoanalytic Psychotherapy
32.04 Psychoanalytic Treatment of Anxiety, Obsessive-Compulsive and Trauma-Related Disorders
32.05 Intensive Short-Term Psychodynamic Psychotherapies
32.06 Individual Psychodynamic Psychotherapy and Cognitive-Behavioral Therapy for Psychosis
32.07 Treatment of Borderline Personality Disorder
32.08 Behavior Therapy
32.09 Cognitive Behavior Therapy
32.10 Interpersonal Psychotherapy
32.11 Dialectical Behavior Therapy
32.12 Solution-Focused Brief Therapy
32.13 Single-Session Therapy
32.14 Mentalization-Based Treatment
32.15 Narrative Psychiatry
32.16 Positive Psychology
32.17 Acceptance and Commitment Therapy
32.18 Hallucinogen-Assisted Psychotherapy
32.19 Hypnosis
32.20 Family and Couples Therapy
32.21 Group Psychotherapy
32.22 Psychodrama, Sociodrama, Sociometry, and Sociatry
32.23 Other Methods of Psychotherapy
32.24 Evaluating Psychotherapy: Research Methods, Findings, and Future Directions

33 Biologic Therapies

33.01 Preface
33.1a General Principles of Psychopharmacology
33.1b Drug Development and Approval Process in the United States
33.1c Classification of Psychotropics: Neuroscience-Based Nomenclature (NbN)
33.02 Dopamine Blockers (“Antipsychotics”)
33.2a Dopamine Antagonists
33.2b Dopamine-Serotonin Antagonists
33.2c Dopamine Blockers and Neuromotor Adverse Effects
33.03 Dopamine Partial Agonists
33.3a Dopamine Partial Agonists
33.04 Dopamine Enhancers
33.4a Dopamine Receptor Agonists
33.4b Amphetamines, Methylphenidate, Atomoxetine, and Modafinil
33.05 Monoamine Enhancers (“Antidepressants”)
33.5a Reuptake Inhibitors
33.5a.1 erotonin Reuptake Inhibitors (SRIs)
33.5a.2 Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
33.5a.3 Tricyclics and Tetracyclics
33.5a.4 Dopamine-Noradrenaline Reuptake Inhibitors (Bupropion)
33.5b 5HT1A Receptor Partial Agonists (Buspirone)
33.5d Monoamine Oxidase Inhibitors
33.06 Monoamine Modulators
33.6a Trazodone
33.6b Nefazodone
33.6c Mirtazapine
33.07 Serotonin Antagonists/Inverse Agonists
33.7a Pimavanserin
33.08 Noradrenaline Modulators
33.8a α2-Adrenergic Receptor Agonists: Clonidine, Clonidine Extended Release, Guanfacine, and Guanfacine Extended Release
33.8b β-Adrenergic Receptor Antagonists
33.09 GABA Enhancers
33.9a Barbiturates and Similarly Acting Substances
33.9b Benzodiazepine Receptor Agonists and Antagonists
33.10 Cation Function Modulators and Lithium (“Mood Stabilizers”)
33.10a Calcium Channel Inhibitors
33.10b Gabapentin, Topiramate, Tiagabine, Levetiracetam, Zonisamide, and Pregabalin
33.10c Carbamazepine
33.10d Lamotrigine
33.10e Valproate
33.10f Lithium
33.11 Acetylcholine Blockers and Enhancers
33.11a Anticholinergics and Amantadine
33.12 Histamine Modulators
33.12a Histamine Blockers and Enhancers
33.13 Pharmacological Treatments of Substance Abuse
33.13a Opioid Receptor Modulators
33.13a.1 Opioid Maintenance Treatments: Methadone and Buprenorphine
33.13a.2 Opioid Receptor Antagonists: Naltrexone and Nalmefene
33.13b Disulfiram and Acamprosate
33.14 Fast-Acting Pharmacologic Treatments
33.14a Esketamine and Ketamine
33.14b MDMA, Psilocybin, Ayahuasca, and Ibogaine
33.15 Hormone Receptor Enhancers
33.15a Melatonin Receptor Agonists
33.15b Thyroid Hormones
33.16 Combination Pharmacotherapy
33.17 Sex and Psychopharmacology
33.17a Sex Differences in Psychopharmacology
33.17b Reproductive Hormonal Therapy: Theory and Practice
33.17c Pharmacologic Treatment of Sexual Dysfunction
33.18 Psychopharmacology Across the Life Cycle
33.18a Pediatric Psychopharmacology
33.18b Biologic Therapies: Geriatric Psychopharmacology
33.19 Biologic Therapies Around the Globe
33.19a Essential List of Medicines
33.19b Biologic Therapies in Africa
33.19c Biologic Therapies in India
33.19d Biologic Therapies in Latin America
33.20 Brain Stimulation
33.20a Electroconvulsive Therapy
33.20b Brain Stimulation Methods
33.20c Neurosurgical Treatments

34 Child Psychiatry

34.01 Introduction and Overview
34.02 Child Development
34.03 Adolescent Development

35 Child Psychiatric Examination

35.01 Psychiatric Examination of the Infant, Child, and Adolescent
35.02 Psychiatric Assessment of Preschool Children
35.03 Neuropsychological and Psychoeducational Assessment of Children
35.04 Psychiatric Emergencies in Children and Adolescents

36 Genetics in Child Psychiatry

37 Neuroimaging in Psychiatric Disorders of Childhood

38 Temperament: Risk and Protective Factors for Child Psychiatric Disorders

39 Intellectual Disability

40 Specific Learning Disorder

41 Developmental Coordination Disorder

42 Communication

42.01 Language Disorder
42.02 Social (Pragmatic) Communication Disorder
42.03 Speech Sound Disorder
42.04 Stuttering
42.05 Unspecified Communication Disorder

43 Autism Spectrum Disorders

44 Attention-Deficit Disorders

44.01 Attention-Deficit/Hyperactivity Disorder
44.02 Adult Manifestations of Attention-Deficit/Hyperactivity Disorder

45 Disruptive Behavior Disorders in Children and Adolescents

46 Feeding and Eating Disorders of Infancy and Early Childhood

47 Tic Disorders

48 Elimination Disorders

49 Other Disorders of Infancy, Childhood, and Adolescence

49.01 Reactive Attachment Disorder and Disinhibited Social Engagement Disorder
49.02 Stereotypic Movement Disorders in Children

50 Mood Disorders in Children and Adolescents

50.01 Depressive Disorders and Suicide
50.02 Early-Onset Bipolar Disorder

51 Anxiety Disorders in Children

51.01 Obsessive-Compulsive Disorder in Childhood
51.02 Posttraumatic Stress Disorder in Children and Adolescents
51.03 Separation Anxiety, Generalized Anxiety, and Social Anxiety
51.04 Selective Mutism

52 Early-Onset Psychotic Disorders

53 Child Psychiatry: Psychiatric Treatment

53.01 Psychodynamic Psychotherapy (Child Psychiatry)
53.02 Cognitive-Behavioral Psychotherapy for Children and Adolescents
53.03 Group Psychotherapy
53.04 Family Therapy
53.05 Pediatric Psychopharmacology
53.06 Inpatient Psychiatric, Partial Hospitalization, and Residential Treatment for Children and Adolescents
53.07 Community-Based Treatment
53.08 The Treatment of Adolescents

54 Child Psychiatry: Special Areas of Interest

54.01 Adoption and Foster Care
54.02 Child Maltreatment
54.03 Children’s Reaction to Illness and Hospitalization
54.04 Psychiatric Sequel of HIV and AIDS
54.05 Adolescent Substance Use Disorders
54.06 Forensic Child and Adolescent Psychiatry
54.07 Ethical Issues in Child and Adolescent Psychiatry
54.08 School Consultation and Collaborating With the Educational System
54.09 Prevention of Psychiatric Disorders in Children and Adolescents
54.10 Child Mental Health Services Research
54.11 Impact of Terrorism and School Shootings on Children
54.12 Impact on Parents of Raising a Child with Psychiatric Illness and/or Developmental Disability
54.13 Pediatric Sleep Disorders
54.14 Internet Gaming Disorder in Youth
54.15 Social Media and Youth
54.16 Gay, Bisexual, Transgender, Queer/Questioning, Intersex, and Asexual (LGBTQIA) Youth
54.17 Racism and Discrimination’s Impact on the Health and Well-Being of Developing Children and Adolescents
54.18 Forensic Evaluations of Child and Adolescent Migrants

55 Geriatric Psychiatry

55.01 Overview
55.1a Introduction to Geriatric Psychiatry
55.02 Assessment
55.2a Psychiatric Assessment of the Older Patient
55.2b Complementary and Integrative Geriatric Psychiatry
55.2c The Aging Brain
55.2d Psychological Changes With Normal Aging
55.2e Neuropsychological Evaluation
55.2f Genetics of Late-Life Neurodegenerative Disorders
55.03 Psychiatric Disorders of Late Life
55.3a Assessment of Functioning
55.3b Psychiatric Problems in the Medically Ill Geriatric Patient
55.3c Sleep Disorders in Older Adults
55.3d Anxiety Disorders in Older Adults
55.3e Geriatric Mood Disorders
55.3f Alzheimer Disease and Other Neurocognitive Disorders
55.3g Delirium
55.3h Schizophrenia and Other Psychotic Disorders
55.3i Personality Disorders
55.3j Alcohol and Substance Abuse in Older Adults
55.04 Treatment of Psychiatric Disorders
55.4a Geriatric Psychopharmacology: General Principles
55.4b Antidepressants and Mood Stabilizers
55.4c Antianxiety Drugs
55.4d Antipsychotic Drugs
55.4e Antidementia Drugs
55.4f Electroconvulsive Therapy and Neurostimulation Treatments
55.4g Psychosocial Factors in Psychotherapy of the Older Adults
55.4h Individual Psychotherapy
55.4i Cognitive-Behavioral Therapy
55.4j Family Intervention and Therapy with Older Adults
55.4k Group Therapy
55.4l Counseling and Support Needs of Dementia Caregivers
55.5 Financial Issues in the Delivery of Geriatric Psychiatric Care
55.06 Special Areas of Interest
55.6a Psychiatric Aspects of Long-Term Care
55.6b Forensic Aspects
55.6c Ethical Issues
55.6d Gender Issues
55.6e The Legal and Ethical Analysis of Older Adult Abuse
55.6f Geriatric Psychiatry: Sexuality and Aging
55.6g HIV and Aging
55.6h Technology for Seniors
55.6i Positive Psychiatry of Aging

56 Public Psychiatry

56.01 Public and Community Psychiatry
56.02 Reforming Health Care
56.03 The Role of the Hospital in the Care of Persons with Mental Illness
56.04 Mental Health Services Research
56.05 The Psychiatric Hospitalist
56.06 Psychiatric Rehabilitation
56.07 A Sociocultural Framework for Mental Health and Substance Abuse Service Inequities
56.08 Criminalization of Persons With Serious Mental Illness

57 Psychiatric Education

57.01 Graduate Psychiatric Education
57.02 Examining Professional Patients

58 Ethics and Forensic Psychiatry

58.01 Clinical-Legal Issues in Psychiatry
58.02 Ethics in Psychiatry
58.03 Correctional Psychiatry

59 History of Psychiatry

60 World Aspects of Psychiatry

Appendix A : History of Psychiatry Table
Appendix B : Glossary of Psychiatry and Psychology Terms
Appendix C : Comparative Diagnoses

Index