Completely reorganized to be more clinically focused on diagnosis and treatment, Principles and Practice of Gynecologic Oncology, Eighth Edition, provides the up-to-date information practitioners, researchers, and students need in an easily accessible manner. Drs. Dennis S. Chi, Dineo Khabele, Don S. Dizon, and Catheryn Yashar oversee an expert team of nternational, multidisciplinary authors who offer practical coverage of the entire field, including new management and treatment strategies for gynecologic cancers. Each disease site now has a dedicated section with individual chapters on epidemiology, pathogenesis, prevention, diagnostic imaging, radiation, chemotherapy, targeted therapy, and more—all designed for quick clinical reference and efficient study.
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Contents
SECTION 1: OVERVIEW OF BASIC BIOLOGY
1.1 Overview of Basic Biology
SECTION 2: VULVAR CANCER
2.1 Epidemiology of Vulvar Cancer
2.2 Vulvar Cancer: Anatomy, Natural History, and Patterns of Spread
2.3 Vulvar Cancer: Etiology, Risk Factors, Genetics, and Molecular Biology
2.4 Vulvar Cancer: Preinvasive Disease
2.5 Vulvar Cancer: Clinical Presentation, Diagnostic Evaluation, and Workup
2.6 Therapy for Vulvar Cancer: Radiation, Systemic Therapy, and Treatment of Persistent and Recurrent Disease
2.7 Surgery for Vulvar Cancer
2.8 Vulvar Cancer: Pathology and Prognostic Factors
2.9 Vulvar Cancer: Follow-Up and Survivorship Issues
2.10 Vulvar Cancer: Future Directions
SECTION 3: VAGINAL CANCER
3.1 Vaginal Anatomy
3.2 Vaginal Cancer: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology
3.3 Symptoms and Diagnosis of Vaginal Intraepithelial Neoplasia and Vaginal Cancer
3.4 Surgery for Vaginal Intraepithelial Neoplasia and Vaginal Cancer
3.5 Prognostic Factors
3.6 Therapeutic Approach for VAIN and Invasive Vaginal Disease
3.7 Treatment of Persistent and Recurrent Vaginal Cancer
3.8 Rare Histologies of Vaginal Cancer
3.9 Vaginal Cancer: Follow-Up, Survivorship Issues, and Summary
SECTION 4: CERVICAL CANCER
4.1 Cervix Uteri: Epidemiology, Etiology, Risk Factors, Anatomy, Natural History, and Patterns of Spread
4.2 Genetics and Molecular Biology of Cervical Cancer
4.3 Cervical Cancer: Clinical Presentation and Diagnostic Evaluation
4.4 Surgery for Cervical Cancer
4.5 Cervical Cancer: Pathology
4.6 Radiation Therapy, Immunotherapy, and Targeted Therapies in Cervix Cancer
4.7 Treatment of Persistent or Recurrent Uterine Cervix Cancer
4.8 Survivorship Issues Following Treatment for Cervical Cancer
SECTION 5: CORPUS: EPITHELIAL TUMORS
5.1 Endometrial Cancer: Introduction, Anatomy, Natural History, and Patterns of Spread
5.2 Endometrial Cancer: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology
5.3 Endometrial Cancer: Clinical Presentation, Diagnostic Evaluation, and Workup
5.4 Surgery for Endometrial Cancer
5.5 Endometrial Cancer: Pathology and Prognostic Factors
5.6 Therapy for Endometrial Cancer: Radiation, Chemotherapy, Targeted, Immunotherapy, and Other New and Novel Agents
5.7 Treatment of Persistent and Recurrent Endometrial Cancer
5.8 Endometrial Cancer: Special Conditions
5.9 Endometrial Cancer: Follow-Up and Survivorship Issues
5.10 Endometrial Cancer: Future Directions
SECTION 6: CORPUS: MESENCHYMAL TUMORS
6.1 Mesenchymal Tumors: Introduction, Anatomy, Natural History, and Patterns of Spread
6.2 Mesenchymal Tumors: Etiology, Epidemiology, and Risk Factors
6.3 Mesenchymal Tumors: Clinical Presentation and Diagnostic Evaluation and Workup
6.4 Surgery for Newly Diagnosed Uterine Corpus Mesenchymal Tumors
6.5 Pathology of Uterine Mesenchymal Tumors
6.6 Radiation Therapy for Uterine Corpus Mesenchymal Tumors
6.7 Chemotherapy for Uterine-Limited and Advanced Uterine Sarcomas
6.8 Surgery for Persistent and Recurrent Uterine Sarcomas
6.9 Uterine Sarcomas: Follow-Up, Survivorship Issues, and Future Directions
SECTION 7: GESTATIONAL TROPHOBLASTIC DISEASE: MOLAR PREGNANCY AND GESTATIONAL TROPHOBLASTIC NEOPLASIA
7.1 Epidemiology, Genetics, and Pathology in Gestational Trophoblastic Disease
7.2 Management of Molar Pregnancy
7.3 Management of Low-Risk Gestational Trophoblastic Neoplasia
7.4 Management of High-Risk Gestational Trophoblastic Neoplasia
7.5 Gestational Trophoblastic Disease: Postdiagnosis and Treatment, Long-Term Sequelae, and Quality-of-Life Issues
SECTION 8: EPITHELIAL OVARIAN CANCER
8.1 Epidemiology and Risk Factors
8.2 Hereditary Ovarian Cancer: BRCA and HNPCC—Panel Testing
8.3 Natural History of the Disease: Patterns of Spread
8.4 Ovarian Cancer: Etiology, Genetics, and Molecular Biology
8.5 Ovarian Cancer: Clinical Presentation and Diagnostic Workup
8.6 Surgery for Ovarian Cancer
8.7 Ovarian Cancer: Pathology
8.8 Epithelial Ovarian Cancer: Prognostic Factors
8.9 Management of Early-Stage Ovarian Cancer
8.10 Management of Borderline Tumors and Low-Grade Serous Tumors
8.11 Management of Advanced-Stage Ovarian Cancer
8.12 Approach to Advanced and Recurrent Clear Cell, Mucinous, or Endometrioid Cancer
8.13 Treatment of Ovarian Carcinosarcoma
8.14 Ovarian Cancer: Survivorship Issues
8.15 Treatment of Persistent and Recurrent Ovarian Cancer and Palliative Care
8.16 New Therapeutics
SECTION 9: OVARIAN GERM CELL TUMORS
9.1 Ovarian Germ Cell Tumors: Introduction, Anatomy, Natural History, and Patterns of Spread
9.2 Malignant Ovarian Germ Cell Tumors: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology
9.3 Ovarian Germ Cell Tumors: Clinical Presentation and Diagnostic Evaluation and Workup
9.4 Surgery for Ovarian Germ Cell Tumors
9.5 Ovarian Germ Cell Tumors: Pathology and Prognostic Factors
9.6 Therapy for Ovarian Germ Cell Tumors: Radiation, Chemotherapy, Targeted Therapy, Immunotherapy, and Other New and Novel
9.7 Treatment of Persistent and Recurrent Ovarian Germ Cell Tumors
9.8 Ovarian Germ Cell Tumors: Special Conditions
9.9 Ovarian Germ Cell Tumors: Follow-Up and Survivorship Issues
9.10 Ovarian Germ Cell Tumors: Future Directions
SECTION 10: OVARIAN SEX CORD-STROMAL TUMORS
10.1 Ovarian Sex Cord-Stromal Tumors: Introduction, Anatomy, Natural History, and Patterns of Spread
10.2 Ovarian Sex Cord-Stromal Tumors: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology
10.3 Ovarian Sex Cord-Stromal Tumors: Clinical Presentation, Diagnostic Evaluation, and Workup
10.4 Surgery for Ovarian Sex Cord-Stromal Tumors
10.5 Ovarian Sex Cord-Stromal Tumors: Pathology and Prognostic Factors
10.6 Therapy for Ovarian Sex Cord-Stromal Tumors: Radiation, Chemotherapy, Targeted Therapy, Immunotherapy, and Other New and
10.7 Treatment of Persistent or Recurrent Sex Cord-Stromal Tumors
10.8 Ovarian Sex Cord-Stromal Tumors: Special Conditions
10.9 Ovarian Sex Cord-Stromal Tumors: Follow-Up and Survivorship Issues
10.10 Ovarian Sex Cord-Stromal Tumors: Future Directions
SECTION 11: BREAST CANCER
11.1 Breast Cancer: Introduction
11.2 Breast Cancer: Epidemiology, Risk Factors, Anatomy, and Natural History
11.3 Breast Cancer: Clinical Presentation
11.4 Breast Imaging
11.5 Breast Pathology
11.6 Surgical Management of the Breast
11.7 Surgical Management of the Axilla
11.8 Endocrine Therapy for Breast Cancer
11.9 Approaches to Systemic Therapy for Breast Cancer: Neoadjuvant and Adjuvant Management
11.10 Radiation Therapy for Breast Cancer
11.11 Multidisciplinary Approach to Breast Cancer Care
11.12 Systemic Treatment for Metastatic Breast Cancer
11.13 Breast Cancer in the Older Patient
11.14 Pregnancy-Associated Breast Cancer
11.15 Breast Cancer: Survivorship Issues
SECTION 12: SPECIAL TOPICS
12.1 Clinical Trials Methodology and Analysis
12.2 Cost-Effective and Value-Based Gynecologic Cancer Care
12.3 Perioperative and Critical Care
12.4 Nutrition Support of Patients With Gynecologic Cancer
12.5 Management of Pain
12.6 Palliative and Supportive Care
12.7 Hereditary Cancer Genetics
12.8 Biologic and Physical Principles of Radiation Oncology
Index