Urinary Bladder Pathology-1판

1 Introduction to Urinary Bladder Pathology 1

2 Normal Anatomy and Histology of the Urinary Bladder with Pathologic Correlates 7

3 Flat Urothelial Lesions 21

4 Papillary and Inverted Tumors 35

5 Invasive Urothelial Carcinoma with Molecular Types 45

6 Morphological Variants of Invasive Urothelial Carcinoma 63

7 Other Types of Carcinoma 83

8 Mesenchymal Tumors 97

9 Neuroendocrine Tumors of the Urinary Bladder 113

10 Bladder Lymphoma and Leukemia 129

11 Secondary Tumors in the Bladder 141

12 Urine Cytology 147

13 Diagnostic Values of Immunohistochemistry in Bladder Cancer 159

14 Molecular Pathology 175

15 Surgical Treatment in Urinary Bladder Cancer 189

16 Medical Treatment with Targeted Therapy for Metastatic Urothelial Bladder Carcinoma 199

17 Bladder Cancer: Specimen Handling and Reporting 211

18 AJCC Staging of Bladder Cancers 229

19 Conclusion and Remarks 249

Index 253


This book focuses on bladder cancer pathology, including primary bladder malignancies and other tumor
varieties, with an emphasis on diagnostic pitfalls and clinical relevance. It also describes normal bladder
histology, benign abnormalities with cancer mimickers, and cancer carcinogenesis, which are important
subject matter for understanding bladder cancers, correct diagnosis, and differential diagnoses. Accurate
diagnosis of bladder cancer plays a central role in daily pathology practice, clinical management, and
prognosis. Advances in immunohistochemistry and molecular pathology have enhanced the accuracy of cancer
pathology diagnoses. In addition to covering the anatomic and histologic features of bladder tumors, this
book also reviews recent molecular and immunohistochemical advances in these areas. Recently updated
clinical management information is also presented in this book.
Written by experts in the field, Urinary Bladder Pathology serves as a useful resource for practicing
pathologists, pathology trainees, and other health professionals who treat patients with bladder cancers.