Nelson Textbook of Pediatrics, 2Vols-22판

  • 저   자 : Robert M. Kliegman
  • 역   자 :
  • 출판사 : Elsevier
  • ISBN(13) : 9780323883054
  • 발행일 : 2024-05-09  /   22판   /   4896 페이지
  • 상품코드 : 29395
  • 적립금: 4,320
  • 정가: $178.99
240,000216,000

Covering every aspect of general pediatric practice, as well as details for many pediatric subspecialists, Nelson Textbook of Pediatrics, 22nd Edition, brings you fully up to date with everything from rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today. Edited and written by experts and prominent members of the pediatric medical community, this comprehensive two-volume reference covers both the science and art of pediatric practice. It remains the reference of choice among pediatricians, pediatric residents, and others
involved in the care of young patients, delivering the information you need in a concise, easy-to-use format for everyday reference and study.

  • Features a user-friendly format with short chapters and subchapters that allow you to quickly find the information you need.
  • Includes more than 60 new chapters on topics covering the impact of social factors on children’s health, the impact of genetic discoveries on understanding diagnosing and treating childhood diseases, updating of current evidenced based diagnostic and therapeutic approaches to childhood diseases, and more.
  • Offers new and expanded information on gene therapy; interferonopathies; reactive infectious mucocutaneous eruption (RIME); e-cigarette or vaping use-associated lung injury (EVALI); monkeypox; food protein-induced enterocolitis syndrome (FPIES); signaling pathway disorders; ciliopathies; very early onset inflammatory bowel disease; Epstein-Barr virus susceptibility disorders; marijuana smoke exposure; and much more.
  • Features hundreds of new figures and tables throughout for visual clarity and quick reference, real-time videos, and regular updates online, written exclusively for Nelson.
  • Provides fresh perspectives from two new associate editors: Abigail M. Schuh and Cara L. Mack, both of Medical College of Wisconsin.
  • Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care.
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

    PART I

    The Field of Pediatrics

    01 Overview Of Pediatrics

    02 Child Health Disparities

    03 Global Child Health

    04 Quality And Value In Healthcare For Children

    05 Safety In Healthcare For Children

    06 Ethics In Pediatric Care

    07 Pediatric Palliative Care

    08 Domestic And International Adoption

    09 Foster And Kinship Care

    10 Medical Evaluation Of The Foreign-Born Child

    11 Cultural Issues In Pediatric Care

    12 Maximizing Children’S Health: Screening, Anticipatory Guidance, And Counseling

    13 Injury Control

    14 Impact Of Violence On Children

    15 Child Trafficking For Sex And Labor

    16 Abused And Neglected Children

    17 Strategies For Health Behavior Change

    PART II

    Growth, Development, and Behavior

    18 Developmental And Behavioral Theories

    19 Positive Parenting And Support

    20 Assessment Of Fetal Growth And Development

    21 The Newborn

    22 The First Year

    23 The Second Year

    24 The Preschool Years

    25 Middle Childhood

    26 Adolescence

    27 Assessment Of Growth

    28 Developmental And Behavioral Surveillance And Screening

    29 Childcare

    30 Loss, Separation, And Bereavement

    31 Sleep Medicine

    PART III

    Behavioral and Psychiatric Disorders

    32 Psychosocial Assessment And Interviewing

    33 Psychopharmacology

    34 Psychotherapy And Psychiatric Hospitalization

    35 Somatic Symptom And Related Disorders

    36 Rumination And Pica

    37 Motor Disorders And Habits

    38 Anxiety Disorders

    39 Mood Disorders

    40 Suicide And Attempted Suicide

    41 Eating Disorders

    42 Disruptive, Impulse-Control, And Conduct Disorders

    43 Tantrums And Breath-Holding Spells

    44 Lying, Stealing, And Truancy

    45 Aggression

    46 Self-Injurious Behavior

    47 Childhood Psychoses

    PART IV

    Learning and Developmental Disorders

    48 Neurodevelopmental And Executive Function And Dysfunction

    49 Attention-Deficit/Hyperactivity Disorder

    50 Dyslexia

    51 Math And Writing Disabilities

    52 Language Development And Communication Disorders

    53 Developmental Delay And Intellectual Disability

    54 Autism Spectrum Disorder

    PART V

    Nutrition

    55 Nutritional Requirements

    56 Feeding Healthy Infants, Children, And Adolescents

    57 Nutrition, Food Security, And Health

    58 Refeeding Syndrome

    59 Malnutrition

    60 Overweight And Obesity

    61 Vitamin A Deficiencies And Excess

    62 Vitamin B Complex Deficiencies And Excess

    63 Vitamin C (Ascorbic Acid) Deficiency And Excess

    64 Vitamin D Deficiency (Rickets) And Excess

    65 Vitamin E Deficiency

    66 Vitamin K Deficiency

    67 Micronutrient Mineral Deficiencies

    PART VI

    Fluid and Electrolyte Disorders

    68 Electrolyte And Acid-Base Disorders

    69 Maintenance And Replacement Therapy

    70 Deficit Therapy

    71 Fluid And Electrolyte Treatment Of Specific Disorders

    PART VII

    Pediatric Drug Therapy

    72 Pediatric Pharmacogenetics, Pharmacogenomics, And Pharmacoproteomics

    73 Principles Of Drug Therapy

    74 Anesthesia And Perioperative Care

    75 Procedural Sedation

    76 Pediatric Pain Management

    77 Poisoning

    78 Complementary Therapies And Integrative Medicine

    PART VIII

    Emergency Medicine and Critical Care

    79 Emergency Medical Services For Children

    80 Triage Of The Acutely Ill Child

    81 Pediatric Emergencies And Resuscitation

    82 Acute Care Of Multiple Trauma

    83 Spinal Cord Injuries In Children

    84 Care Of Abrasions And Minor Lacerations

    85 Neurologic Emergencies And Stabilization

    86 Brain Death

    87 Syncope

    88 Shock

    89 Respiratory Distress And Failure

    90 Altitude-Associated Illness In Children (Acute Mountain Sickness)

    91 Drowning And Submersion Injury

    92 Burn Injuries

    93 Cold Injuries

    PART IX

    Human Genetics

    94 Integration Of Genetics Into Pediatric Practice

    95 The Genetic Approach In Pediatric Medicine

    96 The Human Genome

    97 Patterns Of Genetic Transmission

    98 Cytogenetics

    99 Genetics Of Common Disorders

    100 Epigenome-Wide Association Studies And Disease

    101 Genetic Approaches To Rare And Undiagnosed Diseases

    PART X

    Metabolic Disorders

    102 An Approach To Inborn Errors Of Metabolism

    103 Defects In Metabolism Of Amino Acids

    104 Defects In Metabolism Of Lipids

    105 Defects In Metabolism Of Carbohydrates

    106 Mitochondrial Disease Diagnosis

    107 Mucopolysaccharidoses

    108 Disorders Of Purine And Pyrimidine Metabolism

    109 Hutchinson-Gilford Progeria Syndrome (Progeria)

    110 The Porphyrias

    111 Hypoglycemia

    PART XI

    The Fetus and the Neonatal Infant

    112 Overview Of Mortality And Morbidity

    113 The Newborn Infant

    114 High-Risk Pregnancies

    115 The Fetus

    116 Fetal Intervention And Surgery

    117 The High-Risk Infant

    118 Transport Of The Critically Ill Newborn

    119 Clinical Manifestations Of Diseases In The Newborn Period

    120 Nervous System Disorders

    121 Neonatal Resuscitation And Delivery Room Emergencies

    122 Respiratory Tract Disorders

    123 Digestive System Disorders

    124 Blood Disorders

    125 The Umbilicus

    126 Abstinence Syndromes

    127 The Endocrine System

    128 Dysmorphology

    129 Epidemiology Of Infections

    130 Healthcare-Acquired Infections

    131 Congenital And Perinatal Infections

    PART XII

    Adolescent Medicine

    132 Adolescent Physical And Social Development

    133 Gender And Sexual Identity

    134 Gay, Lesbian, And Bisexual Adolescents

    135 Transgender Care

    136 The Epidemiology Of Adolescent Health Problems

    137 Delivery Of Health Care To Adolescents

    138 Transitioning To Adult Care

    139 Violent Behavior

    140 Substance Abuse

    141 The Breast

    142 Menstrual Problems

    143 Contraception

    144 Adolescent Pregnancy

    145 Adolescent Sexual Assault

    146 Sexually Transmitted Infections

    147 Chronic Overlapping Pain Conditions

    PART XIII

    Immunology

    Section 1 EVALUATION OF THE IMMUNE SYSTEM

    148 Evaluation Of Suspected Immunodeficiency

    Section 2 THE T-, B-, AND NK-CELL SYSTEMS

    149 Lymphocyte Development And Function

    150 Primary Defects Of Antibody Production

    151 Primary Defects Of Cellular Immunity

    152 Immunodeficiencies Affecting Multiple Cell Types

    Section 3 THE PHAGOCYTIC SYSTEM

    153 Neutrophils

    154 Monocytes, Macrophages, And Dendritic Cells

    155 Eosinophils

    156 Disorders Of Phagocyte Function

    157 Leukopenia

    158 Leukocytosis

    Section 4 THE COMPLEMENT SYSTEM

    159 Complement Components And Pathways

    160 Disorders Of The Complement System

    Section 5 HEMATOPOIETIC STEM CELL TRANSPLANTATION

    161 Principles And Clinical Indications Of Hematopoietic Stem Cell Transplantation

    162 Hematopoietic Stem Cell Transplantation From Alternative Sources And Donors

    163 Graft-Versus-Host Disease, Rejection, And Venoocclusive Disease

    164 Infectious Complications Of Hematopoietic Stem Cell Transplantation

    165 Late Effects Of Hematopoietic Stem Cell Transplantation

    PART XIV

    Allergic Disorders

    166 Allergy And The Immunologic Basis Of Atopic Disease

    167 Diagnosis Of Allergic Disease

    168 Allergic Rhinitis

    169 Childhood Asthma

    170 Atopic Dermatitis (Atopic Eczema)

    171 Insect Allergy

    172 Ocular Allergies

    173 Urticaria (Hives) And Angioedema

    174 Anaphylaxis

    175 Serum Sickness

    176 Food Allergy And Adverse Reactions To Foods

    177 Adverse Reactions To Drugs

    PART XV

    Rheumatic Diseases of Childhood (Connective Tissue Disease, Collagen Vascular Diseases)

    178 Evaluation Of Suspected Rheumatic Disease

    179 Treatment Of Rheumatic Diseases

    180 Juvenile Idiopathic Arthritis

    181 Ankylosing Spondylitis And Other Spondyloarthritides

    182 Reactive And Postinfectious Arthritis

    183 Systemic Lupus Erythematosus

    184 Juvenile Dermatomyositis

    185 Scleroderma And Raynaud Phenomenon

    186 Behçet Disease

    187 Sjögren Syndrome

    188 Hereditary Periodic Fever Syndromes And Other Systemic Autoinflammatory Diseases

    189 Amyloidosis

    190 Sarcoidosis

    191 Kawasaki Disease

    192 Vasculitis Syndromes

    193 Musculoskeletal Pain Syndromes

    194 Miscellaneous Conditions Associated With Arthritis

    PART XVI

    Infectious Diseases

    Section 1 GENERAL CONSIDERATIONS

    195 Diagnostic Microbiology

    196 The Microbiome And Pediatric Health

    Section 2 PREVENTIVE MEASURES

    197 Immunization Practices

    198 Infection Prevention And Control

    199 Childcare And Communicable Diseases

    200 Health Advice For Children Traveling Internationally

    201 Fever

    202 Fever Without A Focus In The Neonate And Young Infant

    203 Fever In The Older Child

    204 Fever Of Unknown Origin

    205 Infections In Immunocompromised Persons

    206 Infection Associated With Medical Devices

    Section 3 ANTIBIOTIC THERAPY

    207 Principles Of Antibacterial Therapy

    Section 4 GRAM-POSITIVE BACTERIAL

    Section 4 GRAM-POSITIVE BACTERIAL INFECTIONS

    208 Staphylococcus

    209 Streptococcus Pneumoniae (Pneumococcus)

    210 Group A Streptococcus

    211 Group B Streptococcus

    212 Non–Group A Or B Streptococci

    213 Enterococcus

    214 Diphtheria (Corynebacterium Diphtheriae)

    215 Listeria Monocytogenes

    216 Actinomyces

    217 Nocardia

    Section 5 GRAM-NEGATIVE BACTERIAL

    Section 5 GRAM-NEGATIVE BACTERIAL INFECTIONS

    218 Neisseria Meningitidis (Meningococcus)

    219 Neisseria Gonorrhoeae (Gonococcus)

    220 Kingella Kingae

    221 Haemophilus Influenzae

    222 Chancroid (Haemophilus Ducreyi)

    223 Moraxella Catarrhalis

    224 Pertussis (Bordetella Pertussis And Bordetella Parapertussis)

    225 Salmonella

    226 Shigella

    227 Escherichia Coli

    228 Cholera

    229 Campylobacter

    230 Yersinia

    231 Aeromonas And Plesiomonas

    232 Pseudomonas, Burkholderia, And Stenotrophomonas

    233 Tularemia (Francisella Tularensis)

    234 Brucella

    235 Legionella

    236 Bartonella

    Section 6 ANAEROBIC BACTERIAL

    Section 6 ANAEROBIC BACTERIAL INFECTIONS

    237 Botulism (Clostridium Botulinum)

    238 Tetanus (Clostridium Tetani)

    239 Clostridium Difficile Infection

    240 Other Anaerobic Infections

    Section 7 MYCOBACTERIAL INFECTIONS

    241 Principles Of Antimycobacterial Therapy

    242 Tuberculosis (Mycobacterium Tuberculosis)

    243 Hansen Disease (Mycobacterium Leprae)

    244 Nontuberculous Mycobacteria

    Section 8 SPIROCHETAL INFECTIONS

    245 Syphilis (Treponema Pallidum)

    246 Nonvenereal Treponemal Infections

    247 Leptospira

    248 Relapsing Fever (Borrelia)

    249 Lyme Disease (Borrelia Burgdorferi)

    Section 9 MYCOPLASMAL INFECTIONS

    250 Mycoplasma Pneumoniae

    251 Genital Mycoplasmas (Mycoplasma Hominis, Mycoplasma Genitalium, And Ureaplasma Urealyticum)

    Section 10 CHLAMYDIAL INFECTIONS

    252 Chlamydia Pneumoniae

    253 Chlamydia Trachomatis

    254 Psittacosis (Chlamydia Psittaci)

    Section 11 RICKETTSIAL INFECTIONS

    255 Spotted Fever Group Rickettsioses

    256 Scrub Typhus (Orientia Tsutsugamushi)

    257 Typhus Group Rickettsioses

    258 Ehrlichiosis And Anaplasmosis

    259 Q Fever (Coxiella Burnetii)

    Section 12 FUNGAL INFECTIONS

    260 Principles Of Antifungal Therapy

    261 Candida

    262 Cryptococcus Neoformans And Cryptococcus Gattii

    263 Malassezia

    264 Aspergillus

    265 Histoplasmosis (Histoplasma Capsulatum)

    266 Blastomycosis (Blastomyces Dermatitidis And Blastomyces Gilchristii)

    267 Coccidioidomycosis (Coccidioides Species)

    268 Paracoccidioides Brasiliensis

    269 Sporotrichosis (Sporothrix Schenckii)

    270 Mucormycosis

    271 Pneumocystis Jirovecii

    Section 13 VIRAL INFECTIONS

    272 Principles Of Antiviral Therapy

    273 Measles

    274 Rubella

    275 Mumps

    276 Polioviruses

    277 Nonpolio Enteroviruses

    278 Parvoviruses

    279 Herpes Simplex Virus

    280 Varicella-Zoster Virus

    281 Epstein-Barr Virus

    282 Cytomegalovirus

    283 Roseola (Human Herpesviruses 6 And 7)

    284 Human Herpesvirus 8

    285 Influenza Viruses

    286 Parainfluenza Viruses

    287 Respiratory Syncytial Virus

    288 Human Metapneumovirus

    289 Adenoviruses

    290 Rhinoviruses

    291 Coronaviruses

    292 Rotaviruses, Caliciviruses, And Astroviruses

    293 Human Papillomaviruses

    294 Arboviral Infections

    295 Dengue Fever, Dengue Hemorrhagic Fever, And Severe Dengue

    296 Yellow Fever

    297 Ebola And Other Viral Hemorrhagic Fevers

    298 Lymphocytic Choriomeningitis Virus

    299 Hantavirus Pulmonary Syndrome

    300 Rabies

    301 Polyomaviruses

    302 Human Immunodeficiency Virus And Acquired Immunodeficiency Syndrome

    303 Human T-Lymphotropic Viruses (1 And 2)

    304 Transmissible Spongiform Encephalopathies

    Section 14 ANTIPARASITIC THERAPY

    305 Principles Of Antiparasitic Therapy

    Section 15 PROTOZOAN DISEASES

    306 Primary Amebic Meningoencephalitis

    307 Amebiasis

    308 Giardiasis And Balantidiasis

    309 Cryptosporidium, Cystoisospora, Cyclospora, And Microsporidia

    310 Trichomoniasis (Trichomonas Vaginalis)

    311 Leishmaniasis (Leishmania)

    312 African Trypanosomiasis (Sleeping Sickness; Trypanosoma Brucei Complex)

    313 American Trypanosomiasis (Chagas Disease; Trypanosoma Cruzi)

    314 Malaria (Plasmodium)

    315 Babesiosis (Babesia)

    316 Toxoplasmosis (Toxoplasma Gondii)

    Section 16 HELMINTHIC DISEASES

    317 Ascariasis (Ascaris Lumbricoides)

    319 Trichuriasis (Trichuris Trichiura)

    320 Enterobiasis (Enterobius Vermicularis)

    321 Strongyloidiasis (Strongyloides Stercoralis)

    322 Lymphatic Filariasis (Brugia Malayi, Brugia Timori, And Wuchereria Bancrofti)

    323 Other Tissue Nematodes

    324 Toxocariasis (Visceral And Ocular Larva Migrans)

    325 Trichinellosis (Trichinella Spiralis)

    326 Schistosomiasis (Schistosoma)

    327 Flukes (Liver, Lung, And Intestinal)

    328 Adult Tapeworm Infections

    329 Cysticercosis

    330 Echinococcosis (Echinococcus Granulosus And Echinococcus Multilocularis) 1897 Volume

    PART XVII

    The Digestive System

    Section 1 CLINICAL MANIFESTATIONS OF GASTROINTESTINAL DISEASE

    331 Normal Digestive Tract Phenomena

    332 Major Symptoms And Signs Of Digestive Tract Disorders

    Section 2 THE ORAL CAVITY

    333 Development And Developmental Anomalies Of The Teeth

    334 Disorders Of The Oral Cavity Associated With Other Conditions

    335 Malocclusion

    336 Cleft Lip And Palate

    337 Syndromes With Oral Manifestations

    338 Dental Caries

    339 Periodontal Diseases

    340 Dental Trauma

    341 Common Lesions Of The Oral Soft Tissues

    342 Diseases Of The Salivary Glands And Jaws

    343 Diagnostic Radiology In Dental Assessment

    Section 3 THE ESOPHAGUS

    344 Embryology, Anatomy, And Function Of The Esophagus

    345 Congenital Anomalies

    346 Obstructing And Motility Disorders Of The Esophagus

    347 Dysmotility

    348 Hiatal Hernia

    349 Gastroesophageal Reflux Disease

    350 Eosinophilic Esophagitis, Pill Esophagitis, And Infective Esophagitis

    351 Esophageal Perforation

    352 Esophageal Varices

    353 Ingestions

    Section 4 STOMACH AND INTESTINES

    354 Normal Development, Structure, And Function Of The Stomach And Intestines

    355 Pyloric Stenosis And Other Congenital Anomalies Of The Stomach

    356 Intestinal Atresia, Stenosis, And Malrotation

    357 Intestinal Duplications, Meckel Diverticulum, And Other Remnants Of The Omphalomesenteric Duct

    358 Motility Disorders And Hirschsprung Disease

    359 Ileus, Adhesions, Intussusception, And Closed-Loop Obstructions

    360 Foreign Bodies And Bezoars

    361 Peptic Ulcer Disease In Children

    362 Inflammatory Bowel Disease

    363 Eosinophilic Gastroenteritis

    364 Disorders Of Malabsorption

    365 Intestinal Transplantation In Children With Intestinal Failure

    366 Acute Gastroenteritis In Children

    367 Chronic Diarrhea

    368 Functional Gastrointestinal Disorders

    369 Cyclic Vomiting Syndrome

    370 Acute Appendicitis

    371 Surgical Conditions Of The Anus And Rectum

    372 Tumors Of The Digestive Tract

    373 Inguinal Hernias

    Section 5 EXOCRINE PANCREAS

    374 Embryology, Anatomy, And Physiology Of The Pancreas

    375 Pancreatic Function Tests

    376 Disorders Of The Exocrine Pancreas

    377 Treatment Of Pancreatic Insufficiency

    378 Pancreatitis

    379 Pancreatic Fluid Collections

    380 Pancreatic Tumors

    Section 6 THE LIVER AND BILIARY SYSTEM

    381 Morphogenesis Of The Liver And Biliary System

    382 Manifestations Of Liver Disease

    383 Cholestasis

    384 Metabolic Diseases Of The Liver

    385 Viral Hepatitis

    386 Liver Abscess

    387 Liver Disease Associated With Systemic Disorders

    388 Mitochondrial Hepatopathies

    389 Autoimmune Hepatitis

    390 Drug- And Toxin-Induced Liver Injury

    391 Acute Hepatic Failure

    392 Cystic Diseases Of The Biliary Tract And Liver

    393 Diseases Of The Gallbladder

    394 Portal Hypertension And Varices

    395 Liver Transplantation

    Section 7 PERITONEUM

    396 Peritoneal Malformations

    397 Ascites

    398 Peritonitis

    399 Epigastric Hernia

    PART XVIII

    The Respiratory System

    Section 1 DEVELOPMENT AND FUNCTION

    400 Diagnostic Approach To Respiratory Disease

    401 Chronic Or Recurrent Respiratory Symptoms

    402 Sudden Infant Death Syndrome

    403 Brief Resolved Unexplained Events And Other Acute Events In Infants

    Section 2 DISORDERS OF THE RESPIRATORY

    Section 2 DISORDERS OF THE RESPIRATORY TRACT

    404 Congenital Disorders Of The Nose

    405 Acquired Disorders Of The Nose

    406 Nasal Polyps

    407 The Common Cold

    408 Sinusitis

    409 Acute Pharyngitis

    410 Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, And Peritonsillar Cellulitis/Abscess

    411 Tonsils And Adenoids

    412 Acute Inflammatory Upper Airway Obstruction (Croup, Epiglottitis, Laryngitis, And Bacterial Tracheitis)

    413 Congenital Anomalies Of The Larynx, Trachea, And Bronchi

    414 Foreign Bodies In The Airway

    415 Laryngotracheal Stenosis And Subglottic Stenosis

    416 Bronchomalacia And Tracheomalacia

    417 Neoplasms Of The Larynx, Trachea, And Bronchi

    418 Wheezing, Bronchiolitis, And Bronchitis

    419 Plastic Bronchitis

    420 Emphysema And Overinflation

    421 1-Antitrypsin Deficiency And Emphysema

    422 Other Distal Airway Diseases

    423 Congenital Disorders Of The Lung

    424 Pulmonary Edema

    425 Aspiration Syndromes

    426 Chronic Recurrent Aspiration

    427 Immune And Inflammatory Lung Disease

    428 Community-Acquired Pneumonia

    429 Pleurisy, Pleural Effusions, And Empyema

    430 Bronchiectasis

    431 Pulmonary Abscess

    432 Cystic Fibrosis

    433 Primary Ciliary Dyskinesia (Immotile Cilia Syndrome, Kartagener Syndrome)

    434 Diffuse Lung Diseases In Childhood

    435 Pulmonary Hemosiderosis

    436 Pulmonary Embolism, Infarction, And Hemorrhage

    437 Atelectasis

    438 Pulmonary Tumors

    439 Pneumothorax

    440 Pneumomediastinum

    441 Hydrothorax

    442 Hemothorax

    443 Chylothorax

    444 Bronchopulmonary Dysplasia

    445 Skeletal Diseases Influencing Pulmonary Function

    446 Chronic Respiratory Insufficiency

    PART XIX

    The Cardiovascular System

    Section 1 DEVELOPMENTAL BIOLOGY OF THE CARDIOVASCULAR SYSTEM

    447 Cardiac Development

    448 The Fetal To Neonatal Circulatory Transition

    Section 2 EVALUATION OF THE

    Section 2 EVALUATION OF THE CARDIOVASCULAR SYSTEM AND THE CHILD

    449 History And Physical Examination In Cardiac Evaluation

    450 Laboratory Cardiac Evaluation

    Section 3 CONGENITAL HEART DISEASE

    451 Epidemiology And Genetic Basis Of Congenital Heart Disease

    452 Evaluation And Screening Of The Infant Or Child With Congenital Heart Disease

    453 Acyanotic Congenital Heart Disease: Left-To-Right Shunt Lesions

    454 Acyanotic Congenital Heart Disease: Obstructive Lesions

    455 Acyanotic Congenital Heart Disease: Regurgitant Lesions

    456 Cyanotic Congenital Heart Disease: Evaluation Of The Critically Ill Neonate With Cyanosis And Respiratory Distress

    457 Cyanotic Congenital Heart Disease: Lesions Associated With Decreased Pulmonary Blood Flow

    458 Cyanotic Congenital Heart Disease: Lesions Associated With Increased Pulmonary Blood Flow

    459 Other Congenital Heart And Vascular Malformations

    460 Pulmonary Hypertension

    461 General Principles Of Treatment Of Congenital Heart Disease

    Section 4 CARDIAC ARRHYTHMIAS

    462 Disturbances Of Rate And Rhythm Of The Heart

    463 Sudden Death

    Section 5 ACQUIRED HEART DISEASE

    464 Infective Endocarditis

    465 Rheumatic Heart Disease

    Section 6 DISEASES OF THE MYOCARDIUM

    Section 6 DISEASES OF THE MYOCARDIUM AND PERICARDIUM

    466 Diseases Of The Myocardium

    467 Diseases Of The Pericardium

    468 Tumors Of The Heart

    Section 7 CARDIAC THERAPEUTICS

    469 Heart Failure

    470 Pediatric Heart And Heart-Lung Transplantation

    Section 8 DISEASES OF THE PERIPHERAL

    Section 8 DISEASES OF THE PERIPHERAL VASCULAR SYSTEM

    471 Diseases Of The Blood Vessels (Aneurysms And Fistulas)

    472 Systemic Hypertension

    PART XX

    Diseases of the Blood

    Section 1 THE HEMATOPOIETIC SYSTEM

    473 Development Of The Hematopoietic System

    474 The Anemias

    Section 2 ANEMIAS OF INADEQUATE PRODUCTION

    475 Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia)

    476 Pearson Syndrome

    477 Acquired Pure Red Blood Cell Anemia

    478 Anemia Of Chronic Disease And Renal Disease

    479 Congenital Dyserythropoietic Anemias

    480 Physiologic Anemia Of Infancy

    481 Megaloblastic Anemias

    482 Iron-Deficiency Anemia

    483 Other Microcytic Anemias

    Section 3 HEMOLYTIC ANEMIAS

    484 Definitions And Classification Of Hemolytic Anemias

    485 Hereditary Spherocytosis

    486 Hereditary Elliptocytosis, Hereditary Pyropoikilocytosis, And Related Disorders

    487 Hereditary Stomatocytosis

    488 Paroxysmal Nocturnal Hemoglobinuria And Acanthocytosis

    489 Hemoglobinopathies

    490 Enzymatic Defects

    491 Hemolytic Anemias Resulting From Extracellular Factors—Immune Hemolytic Anemias

    492 Hemolytic Anemias Secondary To Other Extracellular Factors

    Section 4 POLYCYTHEMIA (ERYTHROCYTOSIS)

    493 Polycythemia

    494 Nonclonal Polycythemia

    Section 5 THE PANCYTOPENIAS

    495 Inherited Bone Marrow Failure Syndromes With Pancytopenia

    496 The Acquired Pancytopenias

    Section 6 BLOOD COMPONENT TRANSFUSIONS

    497 Red Blood Cell Transfusions And Erythropoietin Therapy

    498 Platelet Transfusions

    499 Neutrophil (Granulocyte) Transfusions

    500 Plasma Transfusions

    501 Risks Of Blood Transfusions

    Section 7 HEMORRHAGIC AND THROMBOTIC DISEASES

    502 Hemostasis

    503 Hereditary Clotting Factor Deficiencies (Bleeding Disorders)

    504 Von Willebrand Disease

    505 Hereditary Predisposition To Thrombosis

    506 Thrombotic Disorders In Children

    507 Postneonatal Vitamin K Deficiency

    508 Liver Disease

    509 Acquired Inhibitors Of Coagulation

    510 Disseminated Intravascular Coagulation

    511 Platelet And Blood Vessel Disorders

    Section 8 THE SPLEEN

    512 Anatomy And Function Of The Spleen

    513 Splenomegaly

    514 Hyposplenism, Splenic Trauma, And Splenectomy

    Section 9 THE LYMPHATIC SYSTEM

    515 Anatomy And Function Of The Lymphatic System

    516 Abnormalities Of Lymphatic Vessels

    517 Lymphadenopathy

    PART XXI

    Cancer and Benign Tumors

    518 Epidemiology Of Childhood And Adolescent Cancer

    519 Molecular And Cellular Biology Of Cancer

    520 Principles Of Cancer Diagnosis

    521 Principles Of Cancer Treatment

    522 The Leukemias

    523 Lymphoma

    524 Brain Tumors In Childhood

    525 Neuroblastoma

    526 Neoplasms Of The Kidney

    527 Soft Tissue Sarcomas

    528 Neoplasms Of Bone

    529 Retinoblastoma

    530 Gonadal And Germ Cell Neoplasms

    531 Neoplasms Of The Liver

    532 Benign Vascular Tumors

    533 Rare Tumors

    534 Histiocytosis Syndromes Of Childhood

    PART XXII

    Nephrology

    Section 1 GLOMERULAR DISEASE

    535 Introduction To Glomerular Diseases

    Section 2 CONDITIONS PARTICULARLY

    Section 2 CONDITIONS PARTICULARLY ASSOCIATED WITH HEMATURIA

    536 Clinical Evaluation Of The Child With Hematuria

    537 Isolated Glomerular Diseases Associated With Recurrent Gross Hematuria

    538 Multisystem Disease Associated With Hematuria

    539 Tubulointerstitial Disease Associated With Hematuria

    540 Vascular Diseases Associated With Hematuria

    541 Anatomic Abnormalities Associated With Hematuria

    542 Lower Urinary Tract Causes Of Hematuria

    Section 3 CONDITIONS PARTICULARLY

    Section 3 CONDITIONS PARTICULARLY ASSOCIATED WITH PROTEINURIA

    543 Clinical Evaluation Of The Child With Proteinuria

    544 Conditions Associated With Proteinuria

    545 Nephrotic Syndrome

    Section 4 TUBULAR DISORDERS

    546 Tubular Function

    547 Renal Tubular Acidosis

    548 Nephrogenic Diabetes Insipidus

    549 Inherited Tubular Transport Abnormalities

    550 Renal Failure

    551 Renal Transplantation

    PART XXIII

    Urologic Disorders in Infants and Children

    552 Congenital Anomalies And Dysgenesis Of The Kidneys

    553 Urinary Tract Infections

    554 Vesicoureteral Reflux

    555 Obstruction Of The Urinary Tract

    556 Anomalies Of The Bladder

    557 Neuropathic Bladder

    558 Enuresis And Voiding Dysfunction

    559 Anomalies Of The Penis And Urethra

    560 Disorders And Anomalies Of The Scrotal Contents

    561 Trauma To The Genitourinary Tract

    562 Urinary Lithiasis

    PART XXIV

    Gynecologic Problems of Childhood

    563 Gynecologic History And Physical Examination

    564 Vulvovaginitis

    565 Vaginal Bleeding In The Prepubertal Child

    566 Breast Concerns

    567 Polycystic Ovary Syndrome And Hirsutism

    568 Gynecologic Neoplasms And Adolescent Prevention Methods For Human Papillomavirus

    569 Vulvovaginal And Müllerian Anomalies

    570 Gynecologic Care For Girls With Special Needs

    571 Female Genital Mutilation

    PART XXV

    The Endocrine System

    Section 1 DISORDERS OF THE HYPOTHALAMUS AND PITUITARY GLAND

    572 Hormones Of The Hypothalamus And Pituitary

    573 Hypopituitarism

    574 Diabetes Insipidus

    575 Other Abnormalities Of Arginine Vasopressin Metabolism And Action

    576 Hyperpituitarism, Tall Stature, And Overgrowth Syndromes

    577 Physiology Of Puberty

    578 Disorders Of Pubertal Development

    Section 2 DISORDERS OF THE THYROID GLAND

    579 Thyroid Development And Physiology

    580 Disorders Of Thyroxine-Binding Globulin

    581 Hypothyroidism

    582 Thyroiditis

    583 Goiter

    584 Thyrotoxicosis

    585 Carcinoma Of The Thyroid

    586 Autoimmune Polyglandular Syndromes

    587 Multiple Endocrine Neoplasia Syndromes

    Section 3 DISORDERS OF THE PARATHYROID GLAND

    588 Hormones And Peptides Of Calcium Homeostasis And Bone Metabolism

    589 Hypoparathyroidism

    590 Pseudohypoparathyroidism

    591 Hyperparathyroidism

    Section 4 DISORDERS OF THE ADRENAL

    Section 4 DISORDERS OF THE ADRENAL GLAND

    592 Physiology Of The Adrenal Gland

    593 Adrenocortical Insufficiency

    594 Congenital Adrenal Hyperplasia And Related Disorders

    595 Adrenocortical Tumors And Masses

    596 Virilizing And Feminizing Adrenal Tumors

    597 Cushing Syndrome

    598 Primary Aldosteronism

    599 Pheochromocytoma

    Section 5 DISORDERS OF THE GONADS

    600 Development And Function Of The Gonads

    601 Hypofunction Of The Testes

    602 Pseudoprecocity Resulting From Tumors Of The Testes

    603 Gynecomastia

    604 Hypofunction Of The Ovaries

    605 Pseudoprecocity Resulting From Lesions Of The Ovary

    606 Disorders Of Sex Development

    Section 6 DIABETES MELLITUS IN CHILDREN

    607 Diabetes Mellitus

    PART XXVI

    The Nervous System

    608 Neurologic Evaluation

    609 Congenital Anomalies Of The Central Nervous System

    610 Deformational Plagiocephaly

    611 Seizures In Childhood

    612 Conditions That Mimic Seizures

    613 Headaches

    614 Neurocutaneous Syndromes

    615 Movement Disorders

    616 Encephalopathies

    617 Neurodegenerative Disorders Of Childhood

    618 Demyelinating Disorders Of The Central Nervous System

    619 Pediatric Stroke

    620 Central Nervous System Vasculitis

    621 Central Nervous System Infections

    622 Brain Abscess

    623 Idiopathic Intracranial Hypertension (Pseudotumor Cerebri)

    624 Spinal Cord Disorders

    PART XXVII

    Neuromuscular Disorders

    625 Evaluation And Investigation Of Neuromuscular Disorders

    626 Developmental Disorders Of Muscle

    627 Muscular Dystrophies

    628 Endocrine And Toxic Myopathies

    629 Metabolic Myopathies And Channelopathies

    630 Disorders Of Neuromuscular Transmission And Of Motor Neurons

    631 Hereditary Motor-Sensory Neuropathies

    632 Toxic Neuropathies

    633 Autonomic Neuropathies

    634 Guillain-Barré Syndrome

    635 Bell Palsy

    PART XXVIII

    Disorders of the Eye

    636 Growth And Development Of The Eye

    637 Examination Of The Eye

    638 Abnormalities Of Refraction And Accommodation

    639 Disorders Of Vision

    640 Abnormalities Of Pupil And Iris

    641 Disorders Of Eye Movement And Alignment

    642 Abnormalities Of The Lids

    643 Disorders Of The Lacrimal System

    644 Disorders Of The Conjunctiva

    645 Abnormalities Of The Cornea

    646 Abnormalities Of The Lens

    647 Disorders Of The Uveal Tract

    648 Disorders Of The Retina And Vitreous

    649 Abnormalities Of The Optic Nerve

    650 Childhood Glaucoma

    651 Orbital Abnormalities

    652 Orbital Infections

    653 Injuries To The Eye

    PART XXIX

    The Ear

    654 General Considerations And Evaluation Of The Ear

    655 Hearing Loss

    656 Congenital Malformations Of The Ear

    657 External Otitis (Otitis Externa)

    658 Otitis Media

    659 Acute Mastoiditis

    660 The Inner Ear And Diseases Of The Bony Labyrinth

    661 Traumatic Injuries Of The Ear And Temporal Bone

    662 Tumors Of The Ear And Temporal Bone

    PART XXX

    The Skin

    663 Morphology Of The Skin

    664 Dermatologic Evaluation Of The Patient

    665 Principles Of Dermatologic Therapy

    666 Dermatologic Diseases Of The Neonate

    667 Cutaneous Defects

    668 Ectodermal Dysplasias

    669 Vascular Disorders

    670 Cutaneous Nevi

    671 Hyperpigmented Lesions

    672 Hypopigmented Lesions

    673 Vesiculobullous Disorders

    674 Eczematous Disorders

    675 Photosensitivity

    676 Diseases Of The Epidermis

    677 Disorders Of Keratinization

    678 Diseases Of The Dermis

    679 Ehlers-Danlos Syndrome

    680 Diseases Of Subcutaneous Tissue

    681 Disorders Of The Sweat Glands

    682 Disorders Of Hair

    683 Disorders Of The Nails

    684 Disorders Of The Mucous Membranes

    685 Cutaneous Bacterial Infections

    686 Cutaneous Fungal Infections

    687 Cutaneous Viral Infections

    688 Arthropod Bites And Infestations

    689 Acne

    690 Tumors Of The Skin

    691 Nutritional Dermatoses

    PART XXXI

    Bone and Joint Disorders

    Section 1 ORTHOPEDIC PROBLEMS

    692 Growth And Development

    693 Orthopedic Evaluation Of The Child

    694 The Foot And Toes

    695 Torsional And Angular Deformities Of The Limb

    696 Leg-Length Discrepancy

    697 The Knee

    698 The Hip

    699 The Spine

    700 The Neck

    701 The Upper Limb

    702 Arthrogryposis

    703 Common Fractures

    704 Osteomyelitis

    705 Septic Arthritis

    Section 2 SPORTS MEDICINE

    706 Epidemiology And Prevention Of Injuries

    707 Management Of Musculoskeletal Injury

    Stress Fractures, and Chronic Compartment

    708 Sports-Related Traumatic Brain Injury (Concussion)

    709 Cervical Spine Injuries

    710 Heat Injuries

    711 Female Athletes: Menstrual Problems And The Risk Of Osteopenia

    712 Performance-Enhancing Aids

    713 Specific Sports And Associated Injuries

    Section 3 THE SKELETAL DYSPLASIAS

    714 General Considerations In Skeletal Dysplasias

    715 Disorders Involving Cartilage Matrix Proteins

    716 Disorders Involving Transmembrane Receptors

    717 Disorders Involving Ion Transporters

    718 Disorders Involving Transcription Factors

    719 Disorders Involving Defective Bone Resorption

    720 Other Inherited Disorders Of Skeletal Development

    721 Osteogenesis Imperfecta

    722 Marfan Syndrome

    Section 4 METABOLIC BONE DISEASE

    723 Bone Structure, Growth, And Hormonal Regulation

    724 Hypophosphatasia

    725 Hyperphosphatasia

    726 Osteoporosis

    PART XXXII

    Rehabilitation Medicine

    727 Evaluation Of The Child For Rehabilitative Services

    728 Rehabilitation For Severe Traumatic Brain Injury

    729 Spinal Cord Injury And Autonomic Dysreflexia Management

    730 Spasticity

    731 Birth Brachial Plexus Palsy

    732 Meningomyelocele (Spina Bifida)

    733 Ambulation Assistance

    734 Health And Wellness For Children With Disabilities

    PART XXXIII

    Environmental Health

    735 Overview Of Environmental Health And Children

    736 Biologic Effects Of Ionizing Radiation On Children

    737 Chemical Pollutants

    738 Heavy Metal Intoxication

    739 Lead Poisoning

    740 Nonbacterial Food Poisoning

    741 Biologic And Chemical Terrorism

    742 Mass Psychogenic Illness

    743 Animal And Human Bites

    744 Rat Bite Fever

    745 Monkeypox

    746 Envenomations

    PART XXXIV

    747 Laboratory Testing In Infants And Children

    748 Reference Intervals For Laboratory Tests And Procedures

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