Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics-5판

Book Description
Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and
Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response,
taking a conceptual approach that emphasizes clinical application rather than science and mathematics.
Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge
they need to better evaluate drug applications. ◦Key updates reflect advances in PK/PD as related to
clinical decision making and drug research and development.
◦An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students
preparing for a career in clinical practice.
◦Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic
principles and effects.
◦More than 200 carefully written study questions , with answers and in-depth explanations, help readers
enhance their conceptual understanding and learn and retain key information.
◦New and updated examples connect chapter content to real-world settings.
◦Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic
models and parameters.
Enrich Your eBook Reading Experience◦Read directly on your preferred device(s), such as computer, tablet,
or smartphone.
◦Easily convert to audiobook, powering your content with natural language text-to-speech.

Contents:
SECTION 1 BASIC CONSIDERATIONS
CHAPTER 1 Therapeutic Relevance
CHAPTER 2 Fundamental Concepts and T erminology
SECTION 2 EXPOSURE AND RESPONSE AFTER A SINGLE DOSE
CHAPTER 3 Kinetics Following an Intravenous Bolus Dose
CHAPTER 4 Membranes and Distribution
CHAPTER 5 Elimination
CHAPTER 6 Kinetics Following an Extravascular Dose
CHAPTER 7 Absorption
CHAPTER 8 Response
SECTION 3 THERAPEUTIC REGIMENS
CHAPTER 9 Therapeutic W indow
CHAPTER 10 Constant-Rate Input
CHAPTER 11 Multiple-Dose Regimens
SECTION 4 INDIVIDUALIZATION
CHAPTER 12 V ariability
CHAPTER 13 Genetics
CHAPTER 14 Age, W eight, and Gender
CHAPTER 15 Disease
CHAPTER 16 Nonlinearities
CHAPTER 17 Drug Interactions
CHAPTER 18 Initiating and Managing Therapy
SECTION 5 SUPPLEMENTAL TOPICS
CHAPTER 19 Distribution Kinetics
CHAPTER 20 Metabolites and Drug Response
CONTENTS xii Contents
CHAPTER 21 Protein Drugs
CHAPTER 22 Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data