Zipes and Jalife’s Cardiac Electrophysiology-8판

Key Features

•Packs each chapter with the latest information necessary for optimal basic research as well as patient
care.

•Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and
wearable devices.

•Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent
stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with
advanced techniques, and ablation technologies including stereotactic radioablation.

•Includes 47 new chapters covering both basic science and clinical topics.

•Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias,
including new clinical insights on atrial fibrillation and stroke prevention, new advances in the
understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and
infection management.

•Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables,
algorithms, and more., with additional figures, tables, and videos online.

•Recipient of a 2018 Highly Commended award from the British Medical Association.

•Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text,
figures, and references from the book on a variety of devices.


- 도서목차-


1 Voltage-Gated Sodium Channels and Electrical Excitability of the Heart

2 Voltage-Gated Calcium Channels

3 Voltage-Regulated Potassium Channels

4 Molecular Regulation of Cardiac Inward Rectifier Potassium Channel

5 Mammalian Calcium Pumps in Health and Disease

6 Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function

7 Organellar Ion Channels and Transporters

8 Gap Junctional Connexin 43: Novel Insights from the New Millennium and their Clinical Implications

9 Computational modeling and simulation for human cardiac electrophysiology: From induced pluripotent
stem-cell derived cardiomyocytes to adult cardiomyocytes

10 Regulation of Cardiac Calcium Channels

11 Molecular Genetics of ATP-Sensitive Potassium Channels in Cardiovascular Diseases

12 Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity

13 Functional characterization of ion channel gene variants in sudden unexplained natural death

14 Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance

15 Connexins and Pannexins in Cardiovascular Disease

16 Excitation-Contraction Coupling

17 Ion Channel Trafficking in the Heart

17 Ion Channel Trafficking in the Heart

18 Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5

19 Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels

20 Macromolecular Complexes and Cardiac Potassium Channels

21 Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias

22 The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion
and Cell Excitability

23 Function and Dysfunction of Ion Channel Membrane Trafficking and Post Translational Modification

24 Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling

25 Coupled Oscillators and Sinoatrial Pacemaker Activity

25 Coupled Oscillators and Sinoatrial Pacemaker Activity

26 Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants

27 Cell-to-Cell Communication and Impulse Propagation

28 Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation

29 Cell Biology of the Specialized Cardiac Conduction System

30 Computational Predictions of Drug-Induced Arrhythmias

31 Global Optimization Approaches to Generate Dynamically Robust Electrophysiological Models

32 Calcium Signaling in Cardiomyocyte Models with Realistic Geometries

33 Theory of Rotors and Arrhythmias

34 Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associated
with Arrhythmic Risk Markers

35 Computational Approaches for Accurate Rotor localization in the Human Atria

36 Modeling the Aging Heart

37 Electromechanical Vortex Filaments During Cardiac Fibrillation

38 Innervation of the Sinoatrial Node

39 Autonomic and Oxidant Regulation of Cardiac Sodium Currents: Mechanisms and Consequences

40 Neural Activity and Atrial Tachyarrhythmias

41 Sympathetic Modulation of Cardiac Electrophysiology

42 Role of the Autonomic Nervous System in Atrial Fibrillation

43 Rotational and Focal Sources of Atrial Fibrillation: Scientific Rationale and Comparative Clinical
Mapping

44 Nonivasive Frequency-Phase Mapping of Atrial Fibrillation

45 Mechanistic approaches for persistent AF ablation

46 Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation

47 Genetics of Atrial Fibrillation

48 Mechanisms in Genetic Sodium Channel Diseases

49 Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes

50 Inheritable Potassium Channel Diseases

51 Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation

52 Dominant Frequency as a Tool for Personalized Monitoring of Atrial fibrillation Progression and
Upstream Therapy

53 Pharmacogenomics of Cardiac Arrhythmias

54 Screening Drugs for Myocardial Disease in Vivo with Zebrafish

55 Gene Therapy for Atrial Fibrillation

56 Cardiac Remodeling and Regeneration

57 High-Throughput Optical Mapping of 2-Dimensional hiPSC-CM Platforms for Drug Discovery and
Cardiotoxicity Testing

58 Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field
Progenitors

59 The challenges of human iPSC-CM technology: Increasingly complex approaches improve cell maturation and
relevance to modelling human cardiac disease

60 Assessment of the Patient With a Cardiac Arrhythmia

61 Differential Diagnosis of Narrow and Wide Complex Tachycardias

62 Electrocardiographic Monitoring: Short, Long-Term Recording

63 Personal Cardiac Monitoring

64 Computed Tomography for Electrophysiology

65 Magnetic Resonance Imaging for Electrophysiology

66 Intracardiac Echocardiography for Electrophysiology

67 Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk

68 Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Arrhythmias

69 Genetic Testing

70 Supraventricular Tachycardias: Diagnostic Maneuvers in the Electrophysiology Laboratory

71 Atrial Tachycardia

72 Atrioventricular Nodal Reentrant Tachycardia

73 Junctional Tachycardia

74 Preexcitation, Atrioventricular Reentry, Variants

75 Atrial Fibrillation: Mechanisms, Clinical Features, and Management

76 Ablation for Atrial Fibrillation

77 Left Atrial Appendage Management

78 Typical and Atypical Atrial Flutter: Mapping and Ablation

79 Sudden Cardiac Death in Adults

80 Premature Ventricular Complexes

81 Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management

82 PVC Ablation with Anatomic Guidance: Papillary Muscle, Moderator Band and Valve Annulus Sites

83 Fascicular Ventricular Arrhythmias

84 Bundle Branch Reentry Tachycardia

85 Ischemic Heart Disease

86 Ablation of Post-Myocardial Infarction Ventricular Tachycardia

87 Ventricular Tachycardia in Patients with Dilated Cardiomyopathy

88 Lamin A/C, Noncompaction and Other Genetic Cardiomyopathies with Ventricular Arrhythmias

89 Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and
Prevention With Implantable Defibrillators

90 Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

91 Catecholaminergic Polymorphic Ventricular Tachycardia

92 Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy

93 Ventricular Arrhythmias in Takotsubo Cardiomyopathy

94 Mitral Valve Prolapse, ventricular arrhythmias and Sudden Death

95 Brugada Syndrome

96 Long and Short QT Syndromes

97 Andersen-Tawil Syndrome

98 Timothy Syndrome

99 J-Wave Syndromes

100 Idiopathic and Short-Coupled Ventricular Fibrillation

101 Mapping and Ablation of Ventricular Fibrillation

102 Drug-Induced Ventricular Arrhythmias

103 Syncope

104 Sinus Node Abnormalities

105 Postural Orthostatic Tachycardia Syndrome

106 Atrioventricular Block

107 Sex Differences in Arrhythmias

108 Sudden Cardiac Deaths in Athletes, Including Commotio Cordis

109 Cardiac Sarcoidosis

110 Sleep-Disordered Breathing and Arrhythmias

111 Ventricular Assist Devices and Cardiac Transplant Recipients

112 Arrhythmia in Neurologic Disease

113 Cancer Therapy Related Arrhythmias

114 Arrhythmias in the Pediatric Population

115 Supraventricular Tachycardias in Congenital Heart Disease

116 Ventricular Arrhythmias in Congenital Heart Disease

117 Antiarrhythmic Drugs

118 Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death

119 Oral Anticoagulants

120 Implantable Pacemakers

121 Implantable Cardioverter Defibrillators: Technical Aspects

122 Transvenous Implantable Cardioverter Defibrillator: Clinical Aspects

123 Subcutaneous Implantable Cardioverter Defibrillators

124 Wearable Defibrillators

125 Cardiac Resynchronization

126 Management of Implanted Device Infections

127 Electrogram Recording and Signal Processing

128 Electroanatomic Mapping for Arrhythmias

129 Mapping Scar-Related Arrhythmias

130 Radiofrequency Ablation

131 Cryoablation and Other Radiofrequency Alternatives

132 Transvascular Ethanol Ablation

133 Cardiac Radioablation

134 Epicardial Approach in Electrophysiology

135 Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias

136 Surgery for Ventricular Arrhythmias

137 Neuromodulation for the Treatment of Arrhythmias