Fetal and Neonatal Physiology-6판(2Vols)

Description

Offering the comprehensive authoritative information needed for effective diagnosis treatment and management of sickandpremature infantsFetal and Neonatal Physiology 6th Edition is an invaluable resource for board review clinical roundsscientific research and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field intodefinitive guidance for today’s busy practitioner focusing on the basic science needed for exam preparation and keyinformation required for full-time practice. It stands alone as the most complete text available in this complex andfast-changing field yet is easy to use for everyday application.Key Features

• Offers definitive guidance on how to effectively manage the many health problems seen in newborn and prematureinfants.
  
• Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, andDevelopmental Biology of Lung Stem Cells,as well as significantly revised chapters on Cellular Mechanisms of NeonatalBrain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and GastrointestinalMotility,andPhysiology of Twin-Twin Transfusion.
  
• Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 globalcontributors.
  
• Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatalphysiology,as well as clinical applications boxes throughout.
  
• Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quickreferenceand review.
  
• Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection andneuroimaging,and much more.
  
• Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures,andreferences from the book on a variety of devices.
  

Section I. Genetics and Embryology

1. Basic Genetic Principles
2. Epigenetics
3. Basic Embryology
4. Regulation of Embryogenesis
5. The Extracellular Matrix in Development
6. Angiogenesis
7. Prenatal Diagnosis

Section II. Placenta and Intrauterine Environment

8. Placental Development
9. Regulation of the Placental Circulation
10. Mechanisms of Transfer Across the Human Placenta
11. Endocrine and Paracrine Function of the Human Placenta
12. Intra-Amniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome
13. Fetal Origins of Adult Disease: A Classic Hypothesis With New Relevance
14. Placental Function in Intrauterine Growth Restriction

Section III. Developmental Pharmacology

15. Basic Pharmacologic Principles
16. Principles of Pharmacokinetics
17. The Physiology of Placental Drug Disposition
18. Pharmacogenomics
19. Drug Distribution in Fetal Life
20. Drug Transfer During Breastfeeding

Section IV. Intrauterine and Postnatal Growth

21. Placental and Fetal Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
22. Endocrine Factors Affecting Neonatal Growth
23. Human Milk Composition and Function in the Infant
24. Physiology of Lactation

Section V. Perinatal Iron, Mineral, and Vitamin Metabolism

25. Fetal and Neonatal Iron Metabolism
26. Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
27. Zinc in the Fetus and Neonate
28. Vitamin A Metabolism in the Fetus and Neonate
29. Vitamin E Nutrition in Pregnancy and the Newborn Infant
30. Vitamin K Metabolism in the Fetus and Neonate

Section VI. Lipid Metabolism

31. Maternal-Fetal Transfer of Lipid Metabolites
32. Brown Adipose Tissue: Development and Function
33. Lipids as an Energy Source for the Premature and Term Neonate
34. Ketone Body Metabolism in the Neonate
35. Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment

Section VII. Carbohydrate Metabolism

36. Glucose Metabolism in the Fetus and Newborn, and Methods for Its Investigation
37. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
38. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
39. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development

Section VIII. Protein Metabolism

40. General Concepts of Protein Metabolism
41. Placental Transfer and Fetal Requirements of Amino Acids

Section IX. Thermoregulation

42. Temperature Control in Newborn Infants

Section X. Skin

43. Structure and Development of the Skin and Cutaneous Appendages
44. Physiologic Development of the Skin

Section XI. Fetal and Neonatal Cardiovascular Physiology

45. Cardiovascular Development
46. Developmental Electrophysiology in the Fetus and Neonate
47. Developmental Biology of the Pulmonary Vasculature
48. Development of the Gastrointestinal Circulation in the Fetus and Newborn
49. Physiology of Congenital Heart Disease in the Neonate
50. Regulation of Cardiovascular Function During Fetal and Newborn Life
51. Nutritional and Environmental Effects on the Fetal Circulation
52. Mechanisms Regulating Closure of the Ductus Arteriosus
53. Umbilical Circulation
54. Fetal and Placental Circulation During Labor

Section XII. The Lung

55. Normal and Abnormal Structural Development of the Lung
56. Regulation of Alveolarization
57. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
58. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
59. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
60. Upper Airway Structure: Function, Regulation, and Development
61. Regulation of Lower Airway Function
62. Functional Development of Respiratory Muscles
63. Mechanics of Breathing
64. Pulmonary Gas Exchange in the Developing Lung
65. Oxygen Transport and Delivery
66. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
67. Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia
68. Evaluation of Pulmonary Function in the Neonate
69. Mechanisms of Neonatal Lung Injury
70. Impaired Lung Growth After Injury in Preterm Lung
71. Antenatal Factors That Influence Postnatal Lung Development and Injury
72. Regulation of Pulmonary Circulation

Section XIII. Surfactant

73. Historical Perspective
74. Developmental Biology of Lung Stem Cells
75. Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins
76. Structure and Development of Alveolar Epithelial Cells
77. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
78. Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome
79. Surfactant Treatment
80. Genetics and Physiology of Surfactant Protein Deficiencies

Section XVI. Physiology of Gastrointestinal Tract in the Fetus and Neonate

81. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
82. Organogenesis of the Gastrointestinal Tract
83. Development of Gastric Secretory Function
84. Development of the Enteric Nervous System and Gastrointestinal Motility
85. Development of the Endocrine and Exocrine Pancreas
86. Digestive-Absorptive Functions in Fetuses, Infants, and Children
87. The Developing Microbiome of the Fetus and Neonate: A Multiomic Approach

Section XV. Liver and Bilirubin Metabolism

88. Organogenesis and Histologic Development of the Liver
89. Bile Acid Metabolism During Development
90. Fetal and Neonatal Bilirubin Metabolism
91. Hereditary Contributions to Neonatal Hyperbilirubinemia
92. Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia

Section XVI. The Kidney

93. Development of the Kidney: Morphology and Mechanisms
94. Functional Development of the Kidney in Utero
95. Development and Regulation of Renal Blood Flow in the Neonate
96. Postnatal Development of Glomerular Filtration Rate in Neonates
97. Renal Transport of Sodium During Development
98. Potassium Homeostasis in the Fetus and Neonate
99. Role of the Kidney in Calcium and Phosphorus Homeostasis
100. Transport of Amino Acids in the Fetus and Neonate
101. Organic Anion Transport in the Developing Kidney
102. Concentration and Dilution of Urine
103. Urinary Acidification
104. Response to Nephron Loss in Early Development

Section XVII. Fluid and Electrolyte Metabolism

105. Fluid Distribution in the Fetusand Neonate
106. Regulation of Acid-Base Balance in the Fetus and Neonate

Section XVIII. Developmental Hematopoiesis

107. Developmental Biology of Hematopoietic Stem Cells
108. Neutrophil Granulopoiesis and Homeostasis
109. Developmental Erythropoiesis
110. Developmental Megakaryopoiesis

Section XIX. Hemostasis

111. Developmental Hemostasis
112. Platelet–Vessel Wall Interactions

Section XX. Developmental Immunobiology

113. Host Defense Mechanisms Against Bacteria
114. Host Defense Mechanisms Against Fungi
115. Host Defense Mechanisms Against Viruses
116. T-Cell Development
117. B-Cell Development
118. Mononuclear Phagocyte System
119. Normal and Abnormal Neutrophil Physiology in the Newborn
120. The Complement System of the Fetus and Newborn
121. Cytokines and Inflammatory Response in the Fetus and Neonate
122. Immunology of Human Milk
123. Neonatal Pulmonary Host Defense

Section XXI. Neurology

124. Development of the Nervous System
125. Mechanisms of Cell Death in the Developing Brain
126. Development of the Blood-Brain Barrier
127. Trophic Factor, Nutritional, and Hormonal Regulation of Brain Development
128. Developmental Aspects of Pain
129. Cerebellar Development—The Impact of Preterm Birth and Comorbidities
130. Electroencephalography in the Preterm and Term Infant
131. Intraventricular Hemorrhage in the Neonate
132. Pathophysiology of Neonatal White Matter Injury
133. Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection
134. Neuroprotective Therapeutic Hypothermia

Section XXII. Special Sensory Systems in the Fetus and Neonate

135. Early Development of the Human Auditory System
136. Development of Olfaction and Taste in the Human Fetus and Neonate

Section XXIII. Musculoskeletal

137. The Growth Plate: Embryologic Origin, Structure, and Function
138. Ontogenesis of Striated Muscle

Section XXIV. Endocrine Function

139. Hypothalamus: Neuroendometabolic Center
140. Growth Factor Regulation of Fetal Growth
141. Growth Hormone, Prolactin, and Placental Lactogen in the Fetus and Newborn
142. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn Infant
143. Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus
144. Fetal and Neonatal Adrenocortical Physiology
145. Fetal and Neonatal Thyroid Physiology

Section XXV. Ovary and Testis

146. Genetics of Sex Determination and Differentiation
147. Differentiation of the Ovary
148. Testicular Development and Descent

Section XXVI. Pathophysiology of Neonatal Diseases

149. The Pathophysiology of Twin-Twin Transfusion Syndrome, Twin-Anemia Polycythemia Sequence, and Twin-Reversed Arterial Perfusion
150. Physiology of Neonatal Resuscitation
151. Pathophysiology of Neonatal Sepsis
152. Pathophysiology of Neonatal Hypoglycemia
153. Pathophysiology of Cardiomyopathies
154. Pathophysiology of Persistent Pulmonary Hypertension ofthe Newborn
155. Pathophysiology of Shock in theFetus and Neonate
156. Pathophysiology of Apnea of Prematurity
157. Pathophysiology of Respiratory Distress Syndrome
158. Pathophysiology of Meconium Aspiration Syndrome
159. Pathophysiology of Bronchopulmonary Dysplasia
160. Pathophysiology of Ventilator-Dependent Infants
161. Pathophysiology of Gastroesophageal Reflux
162. Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis
163. Pathophysiology of Kernicterus
164. Pathophysiology of Neonatal AcuteKidney Injury
165. Pathophysiology of Edema
166. Pathophysiology of Retinopathy of Prematurity
167. Pathophysiology of Neonatal Hypoxic-Ischemic Brain Injury
168. Pathophysiology of Neonatal Acute Bacterial Meningitis
169. Pathophysiology of NeuralTube Defects
170. Pathophysiology of Preeclampsia
171. Pathophysiology of Preterm Birth
172. Pathophysiology of Chorioamnionitis: Host Immunity and Microbial Virulence
173. Pathophysiology of Genetic Neonatal Disease
174. Genetic Variants and Neonatal Disease

Index