Goodman's Medical Cell Biology-4판

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface

Chapter 1: Tools of the Cell Biologist
Abstract
Microscopy: One of the Earliest Tools of the Cell Biologist
Electron Microscopy
Atomic Force Microscopy
More Tools of Cell Biology
The Techniques of Proteomics and Genomics Are Discussed in Later Chapters
Summary

Chapter 2: Cell Membranes
Abstract
Membrane Lipids
Donnan Effect and Its Relation to Water Flow
Facilitated Transport
Active Transport
Secondary Active Transport
Ion Channels and Membrane Potentials
Summary

Chapter 3: Cytoskeleton
Abstract
Microfilaments
Actin-Binding Proteins
Spectrin Membrane Skeleton
Regulation of Actin Dynamics
Cytoskeleton Participation in Cell Signaling
Intermediate Filaments
Microtubules
Summary

Chapter 4: Organelle Structure and Function
Abstract
The Nucleus
Endoplasmic Reticulum
Leaving the Endoplasmic Reticulum: A Paradigm for Vesicular Traffic
The Golgi Apparatus
Endocytosis, Endosomes, and Lysosomes
Lysosomes
Mitochondria
Peroxisomes
Summary

Chapter 5: Mitochondria and Diseases
Abstract
The Fundamentals of Mitochondrial Biology
Mitochondria and Disease
Treatments for Mitochondrial Disease
Summary

Chapter 6: Regulation of Gene Expression
Abstract
Cell Nucleus
DNA Replication and Repair Are Critical Nuclear Functions
Regulation of Gene Expression
Genetic Therapy
Summary

Chapter 7: Cell Adhesion and the Extracellular Matrix
Abstract
Cell Adhesion
Intercellular Junctions
Role of Cell Adhesion in Tissue Function
Signal Transmission by Cell Adhesion Receptors
Extracellular Matrix
Summary

Chapter 8: General Modes of Intercellular Signaling
Abstract
Intercellular Signaling Molecules Act as Ligands
Cells Exhibit Differential Responses to Signaling Molecules
Intercellular Signaling Molecules Act via Multiple Mechanisms
Hormones
Growth Factors
Histamine
Gases: Nitric Oxide and Carbon Monoxide
Eicosanoids
Neurotransmitters
Summary

Chapter 9: Cell Signaling Events
Abstract
Acknowledgment
Introduction
Kinase Receptor Signaling
Nonkinase Receptor Signaling
G-Protein Coupled Receptors
Ion Channel Receptors
Aberrant Cell Signaling in Cancer
General Mechanisms of Dysregulated Signaling in Cancer
Summary

Chapter 10: Cell Cycle and Cancer
Abstract
Cell Cycle: History
The Cell Cycle Is Regulated by Cyclins and Related Proteins
Mitosis
Meiosis
Sensors Recognize Sites of DNA Damage
Cell-Cycle Perturbations and Cancer
The Checkpoint Kinases and Cancer
Summary

Chapter 11: Regulated Cell Death
Abstract
Cell Death Is Critical in Diverse Aspects of Animal Development and Throughout Adult Life
Distinct Forms of Programmed Cell Death
Apoptosis Is Regulated by a Cell-Intrinsic Genetic Program
The Caspases
Caspase Inhibition
Clearance of the Apoptotic Cell
Apoptosis and Human Disease
Summary

Chapter 12: Cell Biology of the Immune System
Abstract
Introduction
Innate Immune Cell Biology
Antigen Recognition
Antigen Receptor Gene Rearrangement
Antigen Presentation to T Cells and the Human Leukocyte Antigens (HLA)
Signaling Through Antigen-Specific Receptors
Lymphocyte Development
T-Cell Activation and Differentiation
Cellular Effector Mechanisms
B-Cell Activation and Differentiation
Humoral Effector Mechanisms
The Complement System
Immunological Tolerance
Lymphocyte Recirculation
Immunological Hypersensitivity Reactions
Summary

Chapter 13: Stem Cells and Regenerative Medicine
Abstract
Types of Stem Cells
The Properties of Stem Cells
Functions of Adult Stem Cells
Techniques of Stem Cell Processing
Challenges of Stem Cell Processing and Application
The Ethical Issues Associated with Human-Derived Stem Cells
Application of Stem Cells in Regenerative Medicine
Cell-Free Therapeutic Strategy in Regenerative Medicine
Summary and Perspective

Chapter 14: Omics, Informatics, and Precision Medicine
Abstract
Introduction
Genomes, Genes, and DNA Variants
Epigenetics and the Modulation of Transcription
Transcriptomes and the RNA World
Proteomics—The Business End of Omics
Metabolomics and Lipidomics
Bioinformatics and Systems Biology
Genomic Medicine: Prospects and Ethics
Summary

Chapter 15: The Microbiome
Abstract
Introduction to the Microbiome
Major Factors Influencing the Microbiome
Genetics
Therapies Targeting the Microbiome
Summary
Postlude
Index