Fast Facts: Leukemia (From initial gene mutation to survivorship support)

Cover
Title Page
Copyright
Contents
List of abbreviations
Glossary
Introduction

1. Understanding blood and its components
Hierarchical relationship of blood cell development
Regulation of normal blood cell development

2. What is leukemia?
Definitions
Pathophysiology
Classification of leukemias

3. Epidemiology, etiology and risk factors
Epidemiology
Etiology and risk factors

4. Diagnosis
Clinical presentation
Differential diagnoses
Peripheral blood tests
Bone marrow aspiration and biopsy
Cytogenetics and molecular genetics

5. Staging and general management
Acute myeloid leukemia
Acute lymphoblastic leukemia
Chronic myeloid leukemia
Chronic lymphocytic leukemia
B-cell prolymphocytic leukemia
Hairy cell leukemia

6. Supportive care
Replacement of blood products (transfusion support)
Growth factor treatment
Managing fatigue
Treatment of nausea and vomiting
Treatment of hyperuricemia
Central venous catheter placement
Managing pain
Treatment of splenomegaly
Fertility considerations before chemotherapy
Support in survivorship – emotional health
End of life care in advanced disease

7. Emergencies in leukemia
Neutropenic sepsis
Coagulopathy in acute promyelocytic leukemia
Tumor lysis syndrome
Hyperleukocytosis and leukostasis
Differentiation syndrome
Asparaginase-related thromboses in acute lymphoblastic leukemia
Useful resources
Index