Hematopoietic Cell Transplantation for Malignant Conditions-1판

Cover image
Title page
Table of Contents
Copyright
List of Contributors

I. History and Basic Science of Hematopoietic Cell Transplantation

Chapter 1. History and Current Status of Hematopoietic Cell Transplantation
Introduction
Conclusion

II. Hematopoietic Cell Transplantation Pharmacology

Chapter 2. Pharmacology of Drugs Used in Hematopoietic Cell Transplantation
Introduction
Immunosuppressants
Antimicrobial Agents
Antidiarrheal Agents
Miscellaneous

Chapter 3. High-Dose Chemotherapy Regimens
Goals of Conditioning Regimens
Types of Conditioning Regimens
Nonchemotherapy Agents in Conditioning Regimens
Chemotherapy Agents in Conditioning Regimens
Alkylating Agents
Antimetabolites
Platinum Agents
Plant Alkaloids
Anti-T Cell Antibodies
Monoclonal Antibodies
Dosing Considerations

Chapter 4. The Role of Radiation Therapy in Hematopoietic Stem Cell Transplantation
Total-Body Irradiation Therapy
The Role of RT Among Patients with Hodgkin Lymphoma and Non-Hodgkin Lymphoma Undergoing HSCT
Conclusions

III. Workflows and Procedures in Hematopoietic Cell Transplantation

Chapter 5. Sources of Cells for Hematopoietic Cell Transplantation: Practical Aspects of Hematopoietic Cell Collection
Introduction
Sources of Cells for Allogeneic Transplantation
Sources of Cells for Autologous Transplantation

Chapter 6. Patient and Donor Selection and Workup for Hematopoietic Cell Transplantation
Patient Selection and Workup
Donor Selection and Workup

Chapter 7. T-Cell Replete Haploidentical Transplantation
Introduction
Posttransplantation Cyclophosphamide-Based Platform
Conclusions

Chapter 8. Umbilical Cord Blood Transplantation
Introduction
Cord Blood Unit Selection
Future of Cord Blood Transplantation

IV. Hematopoietic Cell Transplantation for Hematologic Malignancies

Chapter 9. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
Introduction
Mechanisms of Allo-HSCT in AML
Acute Myeloid Leukemia—Disease and Classification
Risk Stratification of Acute Myeloid Leukemia
Dynamic Risk Prognostication
Indications for Allo-HSCT
Conditioning Regimens
Myeloablative Conditioning
Reduced Intensity Conditioning
Nonmyeloablative Conditioning
Alternative Donor Transplantation
Transplantation in Induction Failure or in Relapse
Management of Posttransplant Relapse
Preventing AML Relapse with Post-HSCT Maintenance Therapy
Future Direction

Chapter 10. Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia
Introduction
Allogeneic HSCT Beyond CR1
Optimal Conditioning and Donor Selection for allo-HCT for ALL
Advances in the Field of ALL

Chapter 11. Hematopoietic Cell Transplantation for Myeloproliferative Neoplasms
Introduction
Nontransplant Therapies in MF
HCT in MF
Conclusions

Chapter 12. Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia
Introduction
Autologous Hematopoietic Cell Transplant
Allogeneic Hematopoietic Cell Transplant
Discussion

Chapter 13. Allogeneic Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome
Introduction
Who Is a Candidate for Allo-HCT?
Donor Selection
Selecting Hematopoietic Cell Source
The Role of Pretransplant Debulking Treatment
Selection of the Intensity of Conditioning Regimens
Posttransplantation Strategies

Chapter 14. Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin Lymphoma
Introduction
Diffuse Large B Cell Lymphoma (DLBCL)
Follicular Lymphoma
Mantle Cell Lymphoma
Marginal Zone Lymphoma
Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia
Posttransplant Lymphoproliferative Disorder
Plasmablastic Lymphoma
Conclusion

Chapter 15. Allogenic Transplant for Non-Hodgkin Lymphoma
Introduction
B-Cell Lymphomas
Allo-HCT for DLBCL
Follicular Lymphoma
Mantle Cell Lymphoma
Allo-HCT in Other Rare Variants of B-Cell NHL
Relapsed/Refractory T-cell Lymphoma

Chapter 16. Hematopoietic Stem Cell Transplantation for Hodgkin Lymphoma
Role Autologous Stem Cell Transplantation in HL
Factors That Predict Recurrence After Transplantation
Allogeneic Hematopoietic Transplantation in HL
Alternative Donor Allogeneic Transplantation in HL
Complications Associated With Transplantation Specific to HL

Chapter 17. Hematopoietic Cell Transplantation in Patients With Multiple Myeloma
Autologous Stem Cell Transplant: The Standard of Care in Multiple Myeloma
Autologous Stem Cell Transplant in the Era of Novel Agents
Autologous Hematopoeitic Cell Transplant as Part of First-Line or Second-Line Therapy
Single Versus Tandem Autologous Hematopoietic Cell Transplant
The Role of Salvage Autologous Hematopoietic Cell Transplant in MM
Allogeneic Hematopoietic Cell Transplantation for MM
Conclusions

Chapter 18. Hematopoietic Cell Transplantation for Light-Chain Amyloidosis
Introduction
Conclusions
Selected Reading

Chapter 19. Hematopoietic Stem Cell Transplantation for Rare Hematological Malignancies
Introduction
Systemic Mastocytosis
Langerhans Cell Histiocytosis
Chronic Myelomonocytic Leukemia
Hypereosinophilic Syndrome
Primary Central Nervous System Lymphoma
Adult T-Cell Leukemia/Lymphoma
NK Cell Neoplasms
Blastic Plasmacytoid Dendritic Cell Neoplasm
Hepatosplenic T-Cell Lymphoma
Subcutaneous Panniculitic T-Cell Lymphoma
Cutaneous T-cell Lymphomas

V. Hematopoietic Cell Transplantation for Non-Hematologic Malignancies

Chapter 20. Hematopoietic Cell Transplantation for Germ Cell Tumors and Other Adult Solid Tumors
Germ Cell Tumors
Breast Cancer

Chapter 21. Hematopoietic Cell Transplantation for Pediatric Solid Tumors
Hematopoietic Cell Transplantation for Pediatric Solid Tumors

VI. Complications, Infectious Disease, and Special Populations

Chapter 22. Pathophysiology and Management of Graft-Versus-Host Disease
Acute GVHD
Pathophysiology
Clinical Manifestations
Grading of Acute GVHD
Prevention of aGVHD
Treatment
Future Directions
aGVHD (Conclusion)
Chronic GVHD: Introduction
Chronic GVHD: Risk Factors and Epidemiology
Chronic GVHD: Pathophysiology
Chronic GVHD: Clinical Manifestations
Diagnostic Criteria for Chronic GVHD
Chronic GVHD Prophylaxis and Treatment
Future Directions and Novel Therapeutics
Biomarkers
Discussion

Chapter 23. Graft Failure
Definitions
Graft Rejection
Poor Graft Function
Clonal Hematopiesis and Graft Failure
Treatment
Poor Graft Function
Approach

Chapter 24. Miscellaneous Complications Related to Hematopoietic Cell Transplantation
Venoocclusive Disease (Sinusoidal Obstruction Syndrome)
Transplant-Associated Thrombotic Microangiopathy
Respiratory Complications
Endocrine and Metabolic Complications
Adrenal Complications
Renal Complications
Hemorrhagic Cystitis
Cardiac Complications
Neurological Complications
Gastrointestinal Complications
Psychological Complications

Chapter 25. Prophylaxis and Management of Infectious Complications After Hematopoietic Cell Transplantation
Background
Preengraftment Risk Period
Postengraftment Risk Period
Management of Different Infections
Management of Fungal Infections
Management of Viral Infections
Parasitic Infections
Different Syndromes
Donor-Driven Infections
Long-Term Follow-up—Vaccination

Chapter 26. Hematopoietic Stem Cell Transplantation for Hematologic Malignancies in HIV-Positive Patients
Introduction
Epidemiology of HIV-Associated Lymphoma
ASCT in HIV Patients
Allogeneic Stem Cell Transplantation in HIV Patients
cART Management During HSCT
HIV Reservoir
Gene Therapy for Treatment of HIV-1
Conclusions

Chapter 27. Symptom Control and Palliative Care in Hematopoietic Stem Cell Transplantation
Introduction
QOL Measures
Graft-Versus-Host Disease
Mucositis
Nausea and Vomiting
Pain
Delirium
Diarrhea
Palliative Care in Hematopoietic Cell Transplantation

VII. Cellular Therapy

Chapter 28. Principles and Applications of Cellular Therapy in the Setting of Hematopoietic Cell Transplant
Immunologic Status and Reconstitution After hematopoietic cell transplant
Role of Cellular Therapy in Reducing Infectious Post-HCT Morbidity and Mortality
Role of Cellular Therapy in Controlling Graft-Versus-Host Disease
Role of Cellular Therapy in Promoting Engraftment and Potentiating Graft-Versus-Tumor (GVT) Effect
Index