Principles of Bone Biology-4판

Table of Contents

Volume 1

Part I: Basic principles

Section A Cell biology
1. Molecular and cellular regulation of intramembranous and endochondral bone formation during
embryogenesis
2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow
adipocytes
3. Bone marrow and the hematopoietic stem cell niche
4. The osteoblast lineage: its actions and communication mechanisms
5. Osteoclasts
6. The osteocyte
7. Transcriptional control of osteoblast differentiation and function
8. Wnt signaling and bone cell activity
9. Vascular and nerve interactions
10. Coupling of bone formation and resorption
11. Modeling and remodeling: the cellular machinery responsible for bone’s material and structural
strength during growth, aging, and drug therapy
12. Aging and bone

Section B Biochemistry
13. Type I collagen structure, synthesis, and regulation
14. Collagen cross-linking and bone pathobiology
15. Secreted noncollagenous proteins of bone
16. Bone proteinases
17. Integrins and other cell surface attachment molecules of bone cells
18. Intercellular junctions and cellecell communication in the skeletal system

Section C Bone remodeling and mineral homeostasis
19. Histomorphometric analysis of bone remodeling
20. Phosphorus homeostasis and related disorders
21. Magnesium homeostasis
22. Metal ion toxicity in the skeleton: lead and aluminum
23. Biology of the extracellular calcium-sensing receptor

Section D Endocrine and paracrine regulation of bone
24. Parathyroid hormone molecular biology
25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology
26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling
27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney
28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein
29. Structure and function of the vitamin D-binding proteins
30. Vitamin D gene regulation
31. Nonskeletal effects of vitamin D: current status and potential paths forward
32. Cellular actions of parathyroid hormone on bone
33. Calcitonin peptides
34. Regulation of bone remodeling by central and peripheral nervous signals

Section E Other systemic hormones that influence bone metabolism
35. Estrogens and progestins
36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and
pancreatic tissues
37. The pharmacology of selective estrogen receptor modulators: past and present
38. Thyroid hormone and bone
39. Basic and clinical aspects of glucocorticoid action in bone
40. Diabetes and bone
41. Androgen receptor expression and steroid action in bone

Section F Local regulators
42. Growth hormone, insulin-like growth factors, and IGF binding proteins

Volume 2
43. The periodontium
44. Notch and its ligands
45. Fibroblast growth factor (FGF) and FGF receptor families in bone
46. Vascular endothelial growth factor and boneevascular interactions
47. Transforming growth factor-b and skeletal homeostasis
48. Bone morphogenetic proteins
49. Extraskeletal effects of RANK ligand
50. Local regulators of bone
51. Prostaglandins and bone metabolism

Part II: Molecular mechanisms of metabolic bone disease

52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and
their implications
53. Multiple endocrine neoplasia type 1
54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy
55. Localized osteolysis
56. Genetic regulation of parathyroid gland development
57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide
receptor, its ligands, and downstream effector molecules
58. Molecular basis of parathyroid hormone overexpression
59. Diseases resulting from defects in the G protein Gsa
60. Renal osteodystrophy and chronic kidney diseaseemineral bone disorder
61. Osteogenesis imperfecta
62. Hereditary deficiencies in vitamin D action
63. Fibroblast growth factor 23
64. Tumor-induced osteomalacia
65. Osteopetrosis
66. Hypophosphatasia: nature’s window on alkaline phosphatase function in humans
67. Paget’s disease of bone
68. Genetic determinants of bone mass and osteoporotic fracture

Part III: Pharmacological mechanisms of therapeutics

69. Pharmacologic mechanisms of therapeutics: parathyroid hormone
70. Calcium
71. Drugs acting on the calcium receptor: calcimimetics and calcilytics
72. Clinical and translational pharmacology of bisphosphonates
73. Pharmacological mechanisms of therapeutics: receptor activator of nuclear factorekappa B ligand
inhibition
74. Pharmacologic basis of sclerostin inhibition
75. Vitamin D and its analogs
76. Mechanisms of exercise effects on bone quantity and quality

Part IV: Methods in bone research

77. Application of genetically modified animals in bone research
78. Bone turnover markers
79. Microimaging
80. Macroimaging
81. Methods in lineage tracing
82. Bone histomorphometry in rodents
83. Bone strength testing in rodents
84. Regulation of energy metabolism by bone-derived hormones