Schatzberg's Manual of Clinical Psychopharmacology-9판

Cover Page
Title Page
Copyright Page
Contents
Preface
Disclosure of Competing Interests
1 General Principles of Psychopharmacological Treatment
General Advice
Practice Guidelines
Legal, Ethical, and Economic Issues
Technology and Psychopharmacology
Bibliography

2 Diagnosis and Classification
Overall Organization of DSM-5
Neurodevelopmental Disorders
Schizophrenia Spectrum and Other Psychotic Disorders
Mood Disorders
Bipolar and Related Disorders
Depressive Disorders
Anxiety Disorders
Obsessive-Compulsive and Related Disorders
Trauma- and Stressor-Related Disorders
Somatic Symptom and Related Disorders
Personality Disorders
Substance Use Disorders
Feeding and Eating Disorders
FDA Approval of Symptom Reduction Strategies
DSM-5 and Genetics
Summary
Bibliography

3 Antidepressants
History
General Principles of Antidepressant Use
Choosing an Antidepressant
Dosage and Administration
Duration of Treatment
Selective Serotonin Reuptake Inhibitors
Pharmacological Effects
Indications
Side Effects
Overdose
Drug Interactions
Dosage and Administration
Discontinuation
Serotonin-Norepinephrine Reuptake Inhibitors (Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, and
Milnacipran).
Pharmacological Effects
Indications
Side Effects
Overdose
Drug Interactions
Dosage and Administration
Discontinuation
5-HT2 Receptor Antagonists (Trazodone and Nefazodone)
Pharmacological Effects
Indications
Side Effects
Overdose
Drug Interactions
Dosage and Administration
Discontinuation
Combined Noradrenergic-Dopaminergic Antidepressant (Bupropion)
Pharmacological Effects
Indications
Side Effects
Overdose
Drug Interactions
Dosage and Administration
Mirtazapine
Pharmacological Effects
Indications
Side Effects
Overdose
Drug Interactions
Dosage and Administration
Vilazodone
Vortioxetine
Tricyclic and Tetracyclic Antidepressants
Structures
Pharmacological Effects
Indications
Blood Levels
Side Effects
Overdose
Dosage and Administration
Discontinuation
Monoamine Oxidase Inhibitors
Pharmacological Effects
Indications
Side Effects
Overdose
Drug Interactions
Dosage and Administration
Discontinuation
Selective and Reversible Monoamine Oxidase Inhibitors
Novel and Evolving Antidepressant Agents
Ketamine and Esketamine
Allopregnanolone
Buprenorphine and Opiates
Other Novel/Future Antidepressants
Bibliography

4 Antipsychotic Drugs
General Principles of Antipsychotic Use
The Drugs
Efficacy
Acute Antipsychotic Treatment
Early Intervention in First-Episode Psychosis
Inpatient Treatment
Maintenance Drug Therapy
Use in Other Psychiatric Disorders
Second-Generation (Atypical) Antipsychotics
Clozapine
Risperidone
Paliperidone
Iloperidone
Olanzapine
Quetiapine
Ziprasidone
Aripiprazole
Brexpiprazole
Lurasidone
Asenapine
Cariprazine
Pimavanserin
First-Generation (Typical) Antipsychotics
Side Effects
Long-Acting Injectable Antipsychotics
Adjunctive Treatment of Negative and Cognitive Symptoms
Alternatives to Antipsychotic Therapy
Antipsychotic Drugs Newly Released or in Development
Bibliography

5 Mood Stabilizers
General Treatment Approaches
Acute Mania
Acute Bipolar Depression
Maintenance Therapy
Rapid-Cycling Bipolar Disorder
Mixed States
Lithium
History and Indications
Pharmacological Effects
Clinical Indications
Side Effects
Preparations
Dosage and Administration
Use in Pregnancy
Anticonvulsants
Valproate
Carbamazepine
Lamotrigine
Other Anticonvulsants
Antipsychotics
Benzodiazepines
Calcium Channel Blockers
Omega-3 Fatty Acids
Bibliography

6 Antianxiety Agents
Benzodiazepines
Indications
Pharmacological Effects
Subclasses
Dosage and Administration
Withdrawal
Side Effects
Overdose
Antidepressants.
Agoraphobia and Panic
Generalized Anxiety Disorder
Social Anxiety Disorder
Posttraumatic Stress Disorder
Obsessive-Compulsive Disorder
Anticonvulsants
Antipsychotics
Noradrenergic Agents
Clinical Indications
Dosage and Administration
Side Effects
Antihistamines
Buspirone
Novel Anxiolytic Agents
Bibliography

7 Hypnotics
Insomnia
Behavioral Approaches
Pharmacological Approaches
Benzodiazepine Hypnotics
Nonbenzodiazepine Hypnotics
Melatonin Receptor Agonists: Ramelteon and Tasimelteon
Sedative Antihistamines and Other Nonbenzodiazepine Psychoactive Drugs With Hypnotic Properties
Other Hypnotics
Dual Orexin Receptor Antagonists
General Conclusions
Bibliography

8 Stimulants and Other Fast-Acting Drugs
Amphetamine Abuse
Uses of Stimulants
Attention-Deficit/Hyperactivity Disorder
Depression
Acquired Immunodeficiency Syndrome
Binge-Eating Disorder
Other Medical Conditions
Drug Combinations
Psychosis
Stimulant Use Versus Abuse
Atomoxetine
Guanfacine
Other Fast-Acting Drugs
Bibliography

9 Augmentation Strategies for Treatment-Resistant Disorders
Augmentation Strategies for Depression
Lithium-Antidepressant Combinations
Thyroid Supplement–Antidepressant Combinations
Estrogen, DHEA, and Testosterone Combinations With Antidepressants
Dopamine Agonist–Antidepressant Combinations
Monoamine Precursor–Antidepressant Combinations
Bupropion and Mirtazapine Combinations
Other Antidepressant Augmentation Strategies
Antipsychotic-Antidepressant Combinations
Novel Augmenters Under Review
Augmentation/Combination Strategies for Bipolar Disorder
Combinations of Two or More Mood Stabilizers
Mood Stabilizer–Antipsychotic Combinations
Mood Stabilizer–Antidepressant Combinations
Mood Stabilizers and Thyroid Supplements
Mood Stabilizers and Omega-3 Fatty Acids
Augmentation Strategies for Schizophrenia
Combinations of Two Antipsychotics
Combinations of Antidepressants and Antipsychotics
Combinations of Mood Stabilizers and Antipsychotics
Other Augmentation Strategies
Bibliography

10 Emergency Department Treatment
Agitation and Violence
Depression and Suicidality
Acute Psychotic Episodes
Mixed Psychotic Features
Schizophrenic, Schizophreniform, and Manic Psychoses
Delirium
Severe Anxiety
Stupor and Catatonia
Emergency Department Referrals
Bibliography

11 Pharmacotherapy for Substance Use Disorders
Drug Testing
Stimulants
Opiates
Detoxification
Maintenance
Sedatives and Hypnotics
Detoxification
Benzodiazepines
Alcohol
Detoxification
Maintenance Treatment
Nicotine
Cannabis
Hallucinogens
Phencyclidine
Bibliography

12 Pharmacotherapy in Special Situations
Pregnancy
Pediatric Psychopharmacology
Stimulants
Antipsychotics
Antidepressants
Mood Stabilizers
Antianxiety Drugs
Geriatric Psychopharmacology
Antidepressants
Hypnotics and Anxiolytics
Mood Stabilizers
Antipsychotics
Medications for Dementia
Medications for Agitation
Intellectual Disability
Medical Conditions
Psychiatric Disorders Resulting From Medical Illness
Psychiatric Disorders Associated With Nonpsychiatric Drugs
Psychiatric Disorders Complicated by Medical Disorders
Conclusion
Bibliography

13 Laboratory-Guided Pharmacotherapy
Pharmacogenomic Testing
Neurocognitive Testing
Quantitative Electroencephalography
Neuroimaging
Bibliography
Appendix: Suggested Readings
Index