Fetal Therapy-2판

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Updated by a team of internationally renowned experts, this book gives a thorough overview of fetal pathophysiology and an evidence base for in utero: both medical (non-invasive) and surgical treatments. Many topics are expanded to cover recent advances, including: stem cell transplantation; tissue scaffolding; minimally invasive approaches to 'open fetal surgery'; the etiology, prevention and treatment of preterm birth and PROM; the genetic etiologies of fetal disease; and gene therapy. In addition, there are in-depth discussions as to the role of open fetal myelomeningocele repair and several fetoscopic approaches to therapy. The international editors have added important new chapters on reducing stillbirth and prenatal counselling. This book is an invaluable reference guide to the latest fetal therapy options, and an essential, in-depth study book for maternal-fetal and neonatology specialists.

Section 1: General Principles

Chapter 1 The Rationale for Fetal Therapy

Chapter 2 A Fetal Origin of Adult Disease

Chapter 3 Human Embryology: Molecular Mechanisms of Embryonic Disease

Chapter 4 Human Genetics and Fetal Disease: Assessment of the Fetal Genome

Chapter 5 Interventions in Pregnancy to Reduce Risk of Stillbirth

Chapter 6 Fetal Therapy Choices: Uncertain and Emotional Decisions and the Doctor's Role in Parental

Chapter 7 The Ethics of Consent for Fetal Therapy

Chapter 8 Open Fetal Surgery: Is There Still a Role?

Chapter 9 The Artificial Womb

Section 2: Fetal Disease: Pathogenesis and Treatment

Chapter 10 Management of Red Cell Alloimmunization

Chapter 11 Fetal and Neonatal Alloimmune Thrombocytopenia: Clinical Disease and Management

Chapter 12 Structural Heart Disease: Embryology

Chapter 13 Structural Heart Disease: Genetic Influences

Chapter 14 Deciphering the Mechanisms of Developmental Heart Disease: Research from Embryonic Knocko

Chapter 15 In Utero Intervention for Cardiac Disease

Chapter 16 Fetal Cerebral Consequences of Structural Heart Disease: Can These Be Ameliorated?

Chapter 17 Fetal Supraventricular Tachyarrhythmias: Pharmacokinetics, Modes of Action, and Results o

Chapter 18 Fetal Dysrhythmias: Diagnosis and Clinical Management

Chapter 19 Manipulation of Amniotic Fluid Volume: Homeostasis of Fluid Volumes in the Amniotic Cavit

Chapter 20 Oligohydramnios and Polyhydramnios: Therapeutic Manipulation of Amniotic Fluid Volume

Chapter 21 Fetal Infections: Immune Response to Infections during Fetal Life

Chapter 22 Fetal Infections: Clinical Management

Chapter 23 Fetal Growth Restriction: Placental Basis and Implications for Clinical Practice

Chapter 24 Fetal Growth Restriction: Diagnosis and Management

Chapter 25 Screening and Intervention for Fetal Growth Restriction

Chapter 26 Maternal and Fetal Therapy: Can We Optimize Fetal Growth?

Chapter 27 The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets

Chapter 28 Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in

Chapter 29 Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies

Chapter 30 Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to D

Chapter 31 Twin-to-Twin Transfusion Syndrome: Placental and Fetal Pathogenesis

Chapter 32 Twin-to-Twin Transfusion Syndrome: Treatment by Fetoscopic Laser Coagulation of the Place

Chapter 33 Interventions for Early and Late Twin-Twin Transfusion Syndrome

Chapter 34 Diagnosis and Treatment in Twin Anemia Polycythemia Sequence

Chapter 35 Neurological and Long-Term Neurodevelopmental Outcome after Fetal Therapy in Complicated

Chapter 36 The Diagnosis and Detection of Fetal Growth Restriction in Monochorionic Twin Pregnancies

Chapter 37 Clinical Outcome and Management of Selective Fetal Growth Restriction in Monochorionic Tw

Chapter 38 Twin Reversed Arterial Perfusion Sequence: Pathophysiology and In Utero Treatment

Chapter 39 Fetal Reduction and Selective Termination

Chapter 40 Selective Termination of One Fetus in Monochorionic Twin Pregnancies

Chapter 41 Lower Urinary Tract Obstruction: Pathophysiology, Prenatal Assessment, and In Utero Inter

Chapter 42 Fetal Pleural Effusions and Pulmonary Pathology: Pathophysiology and Clinical Management

Chapter 43 Neural Tube Anomalies: An Update on the Pathophysiology and Prevention

Chapter 44 Neural Tube Anomalies: Clinical Management by Open Fetal Surgery

Chapter 45 Open Neural Tube Defect Repair: Development and Refinement of a Fetoscopic Technique

Chapter 46 Fetal Tumors: Clinical Management

Chapter 47 Congenital Diaphragmatic Hernia: Pathophysiology and Antenatal Assessment

Chapter 48 Congenital Diaphragmatic Hernia: In Utero Treatment Today and Tomorrow

Chapter 49 Stem Cell Transplantation: Clinical Potential in Treating Fetal Genetic Disease

Chapter 50 Strategies to Repair Defects in the Fetal Membrane

Chapter 51 Tissue Engineering and the Fetus

Chapter 52 Gene Therapy: Principles and Clinical Potential

Section 3: The Future

Chapter 53 Fetal Therapy and Translational Studies: Global Alignment, Coordination, and Collaboratio

Chapter 54 Congenital Anomaly Registers: The European Experience

Chapter 55 A Challenge for Prenatal Diagnosis in Developing Countries: Zika Virus as an Exemplar

Index