McKee's Pathology of the Skin-5판

Cover image
Title Page
Table of Contents
Copyright
Preface to the fifth edition
List of contributors
Acknowledgments
Dedication
Volume One

Chapter 1 The structure and function of skin
Introduction
Properties of skin
Normal epidermal histology
Regional variations in skin anatomy
Skin development
Keratinocyte biology
Epidermal stem cells
Skin barrier
Skin immunity
Melanocytes
Merkel cells
Intercellular junctions
Pilosebaceous units
Eccrine glands
Apocrine glands
Dermal뻛pidermal junction
Dermal collagen
Dermal elastic tissue
Ground substance
Fibroblast biology
Cutaneous blood vessels and lymphatics
Nervous system of the skin
Subcutaneous fat
References

Chapter 2 Specialized techniques in dermatopathology
Specimen fixation, grossing/put-through, processing, embedding and sectioning
Routine and 몊pecial?stains
Immunohistochemical techniques
Immunohistochemical techniques and trouble shooting
Immunofluorescence
Electron microscopy
Frozen section examination of skin specimens
Diagnostic cytopathological techniques in dermatopathology
Diagnosis of inherited skin diseases
Molecular techniques
Diagnosis of lymphomas
References

Chapter 3 Disorders of keratinization
Ichthyosis
Trichothiodystrophy
Other rare neuro-ichthyotic syndromes
Acquired ichthyosis-like conditions
Erythrokeratoderma
Keratitis-ichthyosis-deafness syndrome, hystrix-like ichthyosis with deafness, porokeratotic adnexal ostial
nevus
Acquired symmetrical acrokeratoderma
Palmoplantar keratoderma
Acquired palmoplantar keratoderma and malignancies
References

Chapter 4 Inherited and autoimmune subepidermal blistering diseases
Split skin immunofluorescence
Immunoperoxidase antigen mapping
Epidermolysis bullosa
Bullous pemphigoid
Pemphigoid gestationis
Lichen planus pemphigoides
Mucous membrane pemphigoid (cicatricial pemphigoid)
Epidermolysis bullosa acquisita (dermolytic pemphigoid)
Bullous systemic lupus erythematosus
Dermatitis herpetiformis
Linear IgA disease
References

Chapter 5 Acantholytic disorders
Introduction
Pemphigus
Acantholytic dermatoses with dyskeratosis
References

Chapter 6 Spongiotic, psoriasiform and pustular dermatoses
Eczematous Dermatitis
Psoriasiform Dermatoses
Pustular Dermatoses
References

Chapter 7 Lichenoid and interface dermatitis
Lichenoid dermatoses
Interface dermatoses
References

Chapter 8 Superficial and deep perivascular inflammatory dermatoses
Chronic superficial dermatitis
Toxic erythema
Lymphocytic infiltrate of the skin (Jessner)
Reticular erythematous mucinosis
Polymorphous light eruption (including juvenile spring eruption and lambing ears)
Tumid lupus erythematosus
Perniosis, atypical chilblains and cold equestrian panniculitis
Chilblain lupus erythematosus
Pigmented purpuric dermatoses including Majocchi disease, Schamberg disease, pigmented purpuric lichenoid
dermatitis of Gougerot and Blum, and itching purpura
Lichen aureus
Pruritic urticarial papules and plaques of pregnancy
Pregnancy prurigo
Urticarial vasculitis
Tumor necrosis factor receptor-associated periodic syndrome (familiar Hibernian fever)
Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy
Viral exanthemata
References

Chapter 9 Granulomatous, necrobiotic and perforating dermatoses
Sarcoidosis
Granuloma annulare
Necrobiosis lipoidica
Rheumatoid nodule
Elastolytic granulomata
Rheumatic fever nodule
Necrobiotic xanthogranuloma
Palisaded neutrophilic and granulomatous dermatitis
멝etastatic?Crohn disease
Acne agminata
Periorificial (perioral) dermatitis
Demodicosis
Infective granulomata
Foreign body granulomata
Granulomatous contact dermatitis
Granulomata in congenital immunodeficiency syndromes
Perforating disorders
Necrotizing infundibular crystalline folliculitis
Chondrodermatitis nodularis chronica helicis
References

Chapter 10 Inflammatory diseases of the subcutaneous fat
Lipodystrophy
References

Chapter 11 Diseases of the oral mucosa
Hereditary Conditions
Reactive Conditions
Ulcerative Conditions
Papillary Lesions
Tumorlike Conditions
Infections
Lichenoid and Hypersensitivity Reactions
Autoimmune Conditions
Salivary Gland Disease
Premalignant Conditions
Squamous Cell Carcinoma and Variants
Oral Lymphoma
Pigmented Lesions
Other Tumors
References

Chapter 12 Diseases of the anogenital skin
Introduction
Normal female anatomy
Normal male anatomy
Embryology
Pubic hair
Anogenital mammary-like glands
Normal variants
Inflammatory dermatoses
Associations with systemic disease
Infectious diseases
Miscellaneous conditions
Genital pigmentation
Benign epithelial lesions
Genital intraepithelial neoplasia and squamous cell carcinoma
Cloacogenic carcinoma
Tumors of anogenital mammary-like glands
Other vulval adnexal neoplasms
Basal cell carcinoma
Metastatic tumors
Lymphoma and leukemia
Juvenile xanthogranuloma
Langerhans cell histiocytosis
Soft tissue tumors
References

Chapter 13 Degenerative and metabolic diseases
The hyperlipidemias
Angiokeratoma corporis diffusum
The amyloidoses
Colloid milium
Hyalinosis cutis et mucosae
Cutaneous macroglobulinosis
Porphyria
Pseudoporphyria
Gout
Ochronosis
Hartnup disease
Pellagra
Scurvy
Calcinosis cutis
The mucinoses
Acanthosis nigricans
Acrodermatitis enteropathica
Necrolytic migratory erythema
Bullosis diabeticorum
References

Chapter 14 Cutaneous adverse reactions to drugs
Adverse Drug Reactions ?Introduction
Adverse Drug Reactions ?Clinical Manifestations
References

Chapter 15 Neutrophilic and eosinophilic dermatoses
Pyoderma gangrenosum
Acute febrile neutrophilic dermatosis (Sweet syndrome)
Neutrophilic dermatoses associated with gastrointestinal and hepatobiliary disease
Rheumatoid neutrophilic dermatitis
Arthropod and arachnid bite reactions
Seabather's eruption and coelenterate stings
Erythema marginatum rheumaticum
Still disease
Urticaria
Papular urticaria
Neutrophilic urticarial dermatosis
Cutaneous atypical neutrophilic dermatosis with lipodystrophy and elevated temperature
Hypereosinophilic syndrome
Eosinophilic cellulitis
Eosinophilic pustular folliculitis
Incontinentia pigmenti
Toxic erythema of the neonate
Hidradenitis suppurativa
Prurigo pigmentosa
References

Chapter 16 Vascular diseases
Introduction
Leukocytoclastic vasculitis
IgA vasculitis (Henoch-Sch?lein purpura)
Infantile acute hemorrhagic edema
Urticarial vasculitis
Granulomatosis with polyangiitis
Eosinophilic granulomatosis with polyangiitis
Microscopic polyangiitis
Polyarteritis nodosa
Kawasaki disease (mucocutaneous lymph node syndrome)
Granuloma faciale
Erythema elevatum diutinum
Beh?t disease
Thromboangiitis obliterans
Giant cell arteritis (temporal arteritis)
Juvenile temporal arteritis
Takayasu arteritis
Infection-related vasculitis
Paraneoplastic vasculitis
Vasculitis associated with palisaded neutrophilic and granulomatous dermatitis
Lymphocytic vasculitis
Malignant atrophic papulosis
Livedoid vasculopathy and atrophie blanche
Dermatological manifestations of cholesterol crystal embolism and embolism from atrial myxoma
Disseminated intravascular coagulation
Cryoglobulinemia
Antiphospholipid antibody syndrome and Sneddon syndrome
Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
Immune thrombocytopenic purpura
Factor V (Leiden) mutation
Hypergammaglobulinemic purpura
Hyperimmunoglobulinemia D syndrome/mevalonate kinase deficiency
Superficial thrombophlebitis
Sclerosing lymphangitis
Senile purpura
Cocaine-related retiform purpura
References

Chapter 17 Idiopathic connective tissue disorders
Lupus erythematosus
Systemic sclerosis
Localized scleroderma (morphea)
Atrophoderma of Pasini and Pierini
Eosinophilic fasciitis
Polymyositis/dermatomyositis
Mixed connective tissue disease
Relapsing polychondritis
References

Chapter 18 Infectious diseases of the skin
Viral Infections
Bacterial Infections
Protozoal Infections
Algal Infections
Fungal Infections
Diseases Caused by Mesomycetozoea
Arthropod Infestations
Nematode Infestation
Trematode Infestation
Cestode Infestation
References
Volume Two

Chapter 19 Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS)-associated
cutaneous diseases
Introduction
Acute HIV exanthem
HIV-associated papulosquamous dermatoses
HIV-associated photodistributed eruptions
HIV-associated pruritic papular eruptions
HIV-associated vasculitic disorders
HIV-associated autoimmune bullous diseases
HIV-associated cutaneous mucinoses
Lichenoid reactions in HIV
HIV interface dermatitis
Other HIV-associated dermatoses
Cutaneous infections
Lipodystrophy in HIV
Neoplasia
Immune reconstitution inflammatory syndrome
Acknowledgments
References

Chapter 20 Disorders of pigmentation
Disorders of Hypopigmentation
Disorders of Hyperpigmentation
References

Chapter 21 Diseases of collagen and elastic tissue
Diseases of Collagen: Generalized Disorders
Diseases of Collagen: Localized Disorders
Diseases of Elastic Tissue
References

Chapter 22 Diseases of the hair
Classification of Alopecia
Hair Shaft Diseases
Miscellaneous Follicular Dermatoses
References

Chapter 23 Diseases of the nails
Introduction
Infectious Diseases of the Nail
Inflammatory Diseases of the Nail
Melanocytic Lesions of the Nail Apparatus
Nonmelanocytic Tumors of the Nail Apparatus
References

Chapter 24 Tumors of the surface epithelium
Epidermal nevi
Cornu cutaneum
Acanthoma fissuratum
Seborrheic keratosis
Dermatosis papulosa nigra
Actinic lentigo
Large cell acanthoma
Stucco keratoses
Intraepidermal epithelioma of Borst-Jadassohn
Porokeratoma
Psoriasiform keratosis
Granular parakeratotic acanthoma
Clear cell acanthoma
Pseudoepitheliomatous hyperplasia
Basal cell carcinoma
Nevoid basal cell carcinoma syndrome
Bazex-Dupr?Christol and Rombo syndromes
Fibroepithelioma of Pinkus
Actinic keratoses
Squamous carcinoma in situ (Bowen disease)
PUVA keratosis
Arsenical keratoses
Squamous cell carcinoma
Variants of squamous cell carcinoma
Metaplastic carcinoma of the skin (carcinosarcoma, carcinoma with heterologous differentiation)
Squamous cell carcinoma with chronic lymphocytic leukemia
Xeroderma pigmentosum
Merkel cell carcinoma
Lymphoepithelioma-like carcinoma of the skin
References

Chapter 25 Melanocytic nevi
Ephelide
Lentigo simplex
Labial melanotic macule and labial lentigo
Laugier-Hunziker syndrome
Oral melanoacanthoma
Cutaneous melanoacanthoma
Peutz-Jeghers syndrome
Genital lentiginosis
Acral lentigo
Multiple lentigines syndrome
Carney complex
Centrofacial lentiginosis
PUVA and sunbed lentigines
Ink spot lentigo
Becker nevus
Pseudomelanocytic nests
Melanocytic nevus
Clonal nevus
Eccrine centered nevus
Melanocytic nevi at special sites
Acral nevus
Nevus spilus
Cockarde nevus
Combined nevus (melanocytic nevus with phenotypic heterogeneity)
Recurrent and sclerosing nevus
Balloon cell nevus
Halo nevus
Meyerson nevus
Spitz nevus, atypical Spitz nevus and spitzoid melanoma
Pigmented epithelioid cell nevus
Pagetoid Spitz nevus
Desmoplastic nevus
Pigmented spindle cell tumor of Reed
Deep penetrating nevus
Dysplastic nevus syndrome and dysplastic nevi
Atypical (dysplastic) lentiginous nevus of the elderly
Congenital nevus
Congenital nevi in neonates and young children
Dermal melanocytic lesions (dermal melanocytoses)
Superficial atypical melanocytic proliferations of unknown significance
Melanocytic tumors of uncertain malignant potential
The molecular pathology of melanocytic nevi
References

Chapter 26 Melanoma
Melanoma
References

Chapter 27 Tumors of the conjunctiva
Introduction
Epithelial tumors
Melanocytic tumors
Hematopoietic tumors
Conjunctival stromal tumors
Vascular tumors
Fibrous tumors
Neural tumors
Histiocytic tumors
Myogenic tumors
Lipomatous tumors
Other tumorlike lesions
Metastatic and secondary tumors
References

Chapter 28 Sentinel lymph node biopsies
Introduction
Laboratory management and gross evaluation of sentinel nodes
Confirmation of the sentinel status of submitted lymph nodes
Can tissue from a sentinel node ethically be made available for research?
Intraoperative evaluation of sentinel nodes
The need to evaluate multiple levels of the sentinel node
The role of immunohistochemistry in detecting tumor in sentinel nodes
Separation of nevus cells and metastatic melanoma in sentinel nodes
Is there a role for SNB in the evaluation of melanocytic lesions of uncertain metastatic potential?
Molecular biology techniques in the assessment of sentinel nodes from melanoma patients
Prediction of outcome based on the extent of nodal replacement by tumor and its distribution within the
sentinel node
Pathological evaluation of nonsentinel nodes
The impact of complete lymph node dissection after positive sentinel lymph node biopsy in melanoma-specific
survival
Lymphatic mapping and sentinel node biopsy for nonmelanocytic neoplasms
Reporting the sentinel node
References

Chapter 29 Cutaneous lymphoproliferative diseases and related disorders
T-Cell Lymphomas
Benign Cutaneous Infiltrates That Can Be Mistaken for Cutaneous T-Cell Lymphoma (Cutaneous T-Cell
Pseudolymphoma)
B-Cell Lymphomas
Benign Cutaneous Infiltrates That Can Be Mistaken for Cutaneous B-Cell Lymphoma (So-Called Cutaneous B-Cell
Pseudolymphoma)
Histiocytic Disorders
Cutaneous and Mucocutaneous Histiocytoses
Cutaneous Leukemic Infiltrates and Precursor Cell Neoplasms
References

Chapter 30 Cutaneous metastases and Paget disease of the skin
Cutaneous Metastases
Mammary and Extramammary Paget Disease
References

Chapter 31 Tumors of the hair follicle
Hair nevi
Hair follicle nevus
Woolly hair nevus
Comedo nevus
Basaloid follicular hamartoma
Dilated pore
Pilar sheath acanthoma
Follicular infundibulum tumor (infundibuloma)
Trichoadenoma
Trichilemmoma and Cowden disease
Desmoplastic trichilemmoma
Trichilemmal carcinoma
Proliferating trichilemmal (pilar) cyst
Pilomatrixoma
Pilomatrix carcinoma
Melanocytic matricoma
Trichofolliculoma
Folliculosebaceous cystic hamartoma
Sebaceous trichofolliculoma
Trichoepithelioma
Desmoplastic trichoepithelioma (sclerosing epithelial hamartoma)
Trichoblastoma
Malignant trichoblastoma
Cutaneous lymphadenoma (lymphoepithelial tumor of the skin)
Perifollicular fibroma
Fibrofolliculoma
Trichodiscoma, Birt-Hogg-Dub? and Hornstein-Knickenberg syndromes
Neurofollicular hamartoma (spindle cell predominant trichodiscoma)
References

Chapter 32 Tumors and related lesions of the sebaceous glands
Ectopic sebaceous glands
Sebaceous hyperplasia
Nevus sebaceous
Steatocystoma and sebocystomatosis
Sebaceous adenoma
Sebaceous epithelioma
Sebaceoma
Superficial epithelioma with sebaceous differentiation
Sebomatricoma
Basal cell carcinoma with sebaceous differentiation
Sebaceous carcinoma
Muir-Torre syndrome
Mantleoma
Other cutaneous tumors showing sebaceous differentiation
References

Chapter 33 Tumors of the sweat glands
Apocrine nevus
Apocrine hidrocystoma and apocrine cystadenoma
Hybrid epidermoid and apocrine cyst
Syringocystadenoma papilliferum
Syringocystadenocarcinoma papilliferum
Hidradenoma papilliferum
Tubular apocrine adenoma
Adenoma and adenocarcinoma of the anogenital mammary-like glands
Nipple adenoma
Syringomatous adenoma of the nipple
Apocrine poroma
Cutaneous oncocytoma
Apocrine carcinoma
Primary cutaneous cribriform apocrine carcinoma
Ceruminous gland tumors
Mixed tumor of the skin
Malignant mixed tumor
Myoepithelioma and malignant myoepithelioma
Eccrine nevus
Adnexal polyp of neonatal skin
Eccrine syringofibroadenoma
Eccrine angiomatous hamartoma
Porokeratotic eccrine ostial and dermal duct nevus
Eccrine hidrocystoma
Hidroacanthoma simplex
Eccrine poroma
Dermal duct tumor
Eccrine porocarcinoma
Syringoma
Papillary eccrine adenoma
Digital papillary adenocarcinoma
Hidradenoma
Clear cell hidradenocarcinoma
Dermal cylindroma
Malignant cylindroma
Eccrine spiradenoma
Eccrine spiradenocarcinoma
Syringoid eccrine carcinoma
Microcystic adnexal carcinoma
Primary cutaneous adenoid cystic carcinoma
Primary cutaneous mucinous carcinoma
Endocrine mucin-producing sweat gland carcinoma
Mammary-type secretory carcinoma of the skin
Eccrine ductal carcinoma
Squamoid eccrine ductal carcinoma
Polymorphous sweat gland carcinoma
Primary cutaneous signet ring cell carcinoma
References

Chapter 34 Cutaneous cysts
Follicular cysts
Glandular cysts
Cutaneous metaplastic synovial cyst
Pilonidal sinus
Dental sinus
Mucinous syringometaplasia
Umbilical polyp and granuloma
Pseudocyst of the auricle
References

Chapter 35 Connective tissue tumors
Adipocytic Tumors
Tumors of Fibrous, Fibroblastic and Myofibroblastic Tissue
Fibrohistiocytic tumors
Nerve Sheath and Neuroectodermal Tumors and Tumorlike Lesions
Smooth Muscle Tumors
Striated Muscle Tumors
Tumors of Vascular Origin
Tumors of Bone and Cartilage-Forming Tissue
Miscellaneous Reactive, Benign Lesions and Tumors of Uncertain Differentiation
Miscellaneous Low-Grade and Malignant Tumors
References

Chapter 36 Animal models of skin disease
Introduction
One gene, one disease
Comparative anatomy of the human and mouse skin and adnexa
Specialized techniques for mouse skin
Creation of models of human disease
Examples of mouse models for human skin in health and disease
Infectious diseases
Vascular changes in the skin
Genetic-based skin diseases
Coat color genetics
A locus
B locus
C locus
D locus
P locus
Mouse models of melanoma
Carcinogen-induced melanoma
Genetically engineered mouse melanoma models
Syngeneic mouse melanoma models
Humanized mouse melanoma models
Anhidrotic ectodermal dysplasia: mouse models that helped define the receptor-ligand concept
Hairless, rhino, papular atrichia and genocopies
Alopecia areata
Psoriasiform mouse models
Xenographs: transplanting tissues from humans to mice
Currently missing mouse models of human skin pathology
Zebrafish as a model system to study skin biology and pathology
Zebrafish skin development
The zebrafish genome and genetic manipulation
Application of the zebrafish model for skin research
Summary
Resources
References
Index
Glossary of abbreviations