The Cutaneous Lymphoid Proliferations-2판

Acknowledgments

CHAPTER 1 Introduction to the Classification of Lymphoma
Kiel Lukes–CollinsWorking Formulation classifications
WHO, REAL, EORTC, and the Combined WHO/EORTC classifications
Summary
References
Appendix: Definitions of key terms and techniques
Plasma cell markers
Natural killer cell-associated markers
Cytotoxic protein markers
B cell markers
Myelomonocytic markers including dendritic cell markers
Follicular dendritic cell markers
Special techniques
Summary of antibodies, clones, and dilutions

CHAPTER 2 The Therapy of Cutaneous T Cell Lymphoma
Introduction
Diagnostic work-up and staging procedures
CTCL therapies
Goals of therapy in advanced-stage CTCL
Extracorporeal photopheresis (ECP)
Interferons
Retinoids
Immunotoxins
Monoclonal antibodies
Histone deacetylase inhibitors (HDACi)
Antibody drug conjugates (ADC)
Cytotoxic chemotherapy
Investigational therapies
TLR agonists and cytokines
Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
References

CHAPTER 3 Molecular Analysis in Cutaneous Lymphoid Proliferation
Introduction
Immunoglobulin and T cell receptor structure
PCR design for determination of clonality
Detection of PCR products for clonality
Evaluation of results
The value and utility of molecular diagnostics in primary cutaneous lymphomas
Limitations of clonality assessment by PCR
Case vignettes
References

CHAPTER 4 Benign Lymphocytic Infiltrates
Introduction
Spongiotic and eczematous dermatitis
Other spongiotic/eczematous tissue reactions
Other causes of subacute eczematous dermatitis
Interface dermatitis: cell-poor vacuolar interface dermatitis
Interface dermatitis: lichenoid pattern
Diffuse and nodular lymphocytic dermal infiltrates without atypia
Diffuse and nodular lymphocytic infiltrates associated with autoimmune disease
References

CHAPTER 5 Reactive Lymphomatoid Tissue Reactions Mimicking Cutaneous T and B Cell Lymphoma
Lymphomatoid drug eruptions
Molecular profile of lymphomatoid drug eruptions
Pathogenetic basis of lymphomatoid drug reactions
Reactive lymphomatoid lesions encountered in lesions of collagen vascular disease
Angiomatous Variants of Pseudolymphoma
Case vignettes
References

CHAPTER 6 Precursor Lesions of Cutaneous T Cell Lymphoma
Cutaneous T cell lymphoid dyscrasia
Large plaque parapsoriasis
Hypopigmented interface T cell dyscrasia: a unique indolent T cell dyscrasia
Pigmented purpuric dermatosis (PPD)
Pityriasis lichenoides
Idiopathic erythroderma (pre-Sézary syndrome)
Syringolymphoid hyperplasia with alopecia
Folliculotropic T cell lymphocytosis/pilotropic T cell dyscrasia
Idiopathic follicular mucinosis/alopecia mucinosa
Keratoderma-like T cell dyscrasia
Atypical lymphocytic lobular panniculitis
Case vignettes
References

CHAPTER 7 Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative
Disorders of The Skin
Marginal zone lymphoma
Blastic marginal zone lymphoma
Epidermotropic marginal zone lymphoma
Castleman disease
Primary cutaneous plasmacytoma
Primary cutaneous light chain associated cutaneous amyloidosis
Case vignettes
References

CHAPTER 8 Primary Cutaneous Follicle Center Cell Lymphoma
Clinical features
Pathology
Phenotypic profile
Molecular studies
Pathogenesis
Cytogenetics
Case vignettes
Additional molecular and cytogenetic study
References

CHAPTER 9 Primary Cutaneous Diffuse Large B Cell Lymphoma Including the Leg Type and Precursor B Cell
Lymphoblastic Lymphoma
Primary cutaneous diffuse large B cell lymphoma
Systemic diffuse large B cell lymphomas with a propensity to involve the skin
Case vignettes
Additional light microscopic, phenotypic, molecular, cytogenetic studies
References

CHAPTER 10 Intravascular Lymphoma
Clinical features
Light microscopic findings
Phenotypic profile
Molecular and cytogenetic studies
Pathogenesis
Differential diagnosis
Intravascular anaplastic large cell lymphoma
Benign intravascular proliferations of histiocytes and reactive T cells
Case vignette
References

CHAPTER 11 Cutaneous Mantle Cell Lymphoma
Clinical features
Light microscopic findings
Phenotypic profile
Molecular studies
Cytogenetic profile
Pathogenesis
Case vignettes
Additional molecular and cytogenetic studies
References

CHAPTER 12 Mycosis Fungoides and Sézary Syndrome
Definition
Mycosis fungoides
Sézary syndrome and erythrodermic mycosis fungoides
Large cell transformation of mycosis fungoides
Extracutaneous involvement in mycosis fungoides
Case vignettes
References

CHAPTER 13 Cd30-Positive Lymphoproliferative Disorders Including Lymphomatoid Papulosis, Borderline Cd30-
Positive Lymphoproliferative Disease, Anaplastic Large Cell Lymphoma, and T-Cell-Rich Cd30-Positive Large B
Cell Lymphoma
Introduction
Lymphomatoid papulosis
CD8+ lymphomatoid papulosis, including the type D variant
Type E lymphomatoid papulosis (Case vignette 15)
Borderline CD30-positive lymphoproliferative disorders (type C LYP) (Case vignette 9)
Lymphomatoid papulosis with a rearrangement on chromosome 6p25.3
Cutaneous anaplastic large cell lymphoma
Small cell ALCL
Additional unusual histologic variants of anaplastic large cell lymphoma
Breast-implant-associated anaplastic large cell lymphoma
Intravascular anaplastic large cell lymphoma
Sarcomatoid anaplastic large cell lymphoma (Case vignette 14)
CD30-positive large B cell lymphoma
Case vignettes
References

CHAPTER 14 CD4+ peripheral T cell lymphoma, not otherwise specified, including primary cutaneous CD4+
small/medium-sized pleomorphic T cell lymphoma
Introduction
Primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma
CD30-negative large cell T cell lymphoma
Cutaneous follicular helper T cell lymphoma
Overview of overall prognosis of primary cutaneous peripheral T cell lymphoma, unspecified
Evolution of the nomenclature of primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma
Case vignettes
References

CHAPTER 15 Subcutaneous Panniculitis-Like T Cell Lymphoma
Clinical features
Morphology
Phenotype
Molecular studies
Differential diagnosis
Case vignettes
References

CHAPTER 16 CD8 T Cell Lymphoproliferative Disease of the Skin
Overview
Introduction
Classification of primary CD8+ cutaneous T cell lymphomas
Histomorphology of primary cutaneous CD8+ T cell lymphoma: primary cutaneous aggressive epidermotropic CD8+
cytotoxic T cell lymphoma, and CD8+ variants of peripheral T cell lymphoma, NOS, including primary
cutaneous CD8+ granulomatous T cell lymphoma
CD8 variant of lymphomatoid papulosis and other related CD30-positive T cell lymphoproliferative disorders
of CD8 subtype
Light microscopic findings
Indolent CD8 positive lymphoid proliferation of the face and other body sites including acral surfaces
CD8 prolymphocytic leukemia
CD8 pseudolymphoma related to underlying HIV disease
Drug-associated CD8+ pseudolymphoma
Actinic reticuloid as a unique form of CD8+ pseudolymphoma
Case vignettes
References

CHAPTER 17 Nasal and Related Extranodal Natural Killer Cell/T Cell Lymphomas and Blastic Plasmacytoid
Dendritic Cell Neoplasm
Introduction
Biology of NK and NK-like T cells
NK/T-cell lymphoma
Nasal NK/T cell lymphoma
Nasal type NK/T cell lymphoma
Aggressive NK cell lymphoma
Role of Epstein–Barr virus in the evolution of NK/T cell lymphomas
Blastic plasmacytoid dendritic cell neoplasm
CD56-positive γ δ lymphoma involving the subcutaneous fat
Chronic granular lymphocytosis/large granular cell leukemia
Natural killer-like CD4+ T cell lymphoma
EBV-associated NK/T cell lymphomas of the elderly
Hydroa vaccineforme (HV)-like lymphoma
Cutaneous intravascular NK T cell lymphoma
Case vignettes
References

CHAPTER 18 Primary Cutaneous γ δ T Cell Lymphoma
Introduction
Case vignettes
Additional supplemental figures
References

CHAPTER 19 Epstein–Barr Virus-Associated Lymphoproliferative Disease
Introduction
Hydroa vacciniforme-like EBV-associated T cell lymphoproliferative disease/mosquito bite hypersensitivity
EBV+ cutaneous B cell lymphoproliferative disorder of the elderly (Case vignette 4, Figures 19.15, 19.16,
19.17, 19.18, 19.19, 19.20, and 19.21)
EBV-associated mucocutaneous ulcer
EBV + T cell lymphoproliferative disease of the elderly
General principles regarding EBV-associated lymphomagenesis
Pathogenetic link between EBV-associated B cell lymphoma and iatrogenic immune dysregulation related to
either methotrexate or cyclosporine
Case vignettes
References

CHAPTER 20 Hodgkin Lymphoma of the Skin
Clinical features
Subtypes of Hodgkin lymphoma
Case vignettes
References

CHAPTER 21 Chronic Lymphocytic Leukemia of B Cell and T Cell Prolymphocytic Leukemia
B cell chronic lymphocytic leukemia
T cell prolymphocytic leukemia
Case vignettes
References

CHAPTER 22 Adult T Cell Leukemia/Lymphoma
Clinical features
Pathology
Phenotypic studies
Pathogenesis
Infective dermatitis of childhood
Case vignettes
References

CHAPTER 23 Angioimmunoblastic Lymphadenopathy/Angioimmunoblastic T Cell Lymphoma
Clinical features
Light microscopic findings
Phenotypic studies
Molecular studies
Pathogenesis
Case vignettes
References

CHAPTER 24 Lymphomatoid Granulomatosis
Introduction
Clinical features (see Table 24.1)
Histopathology
Histogenesis
Clonality studies
Differential diagnosis (see Table 24.2)
Treatment
Case vignette
References

CHAPTER 25 Cutaneous Infiltrates of Myeloid Derivation
Introduction
Leukemia cutis
Clonal histiocytopathy syndromes
Histiocytopathy of factor XIIIA perivascular dermal dendritic cell origin
Case vignettes
References
Index
EULA