Rook's Textbook of Dermatology(4 Vol)-9판

Associate Editors
Contributors
Preface to the Ninth Edition
Preface to the First Edition
Part 1 Foundations of Dermatology
Chapter 1 History of Dermatology
INTRODUCTION: WHEN DID DERMATOLOGY HISTORY BEGIN?
ANCIENT DERMATOLOGY WRITINGS
GROWTH OF RATIONAL MEDICINE
DERMATOLOGY AFTER THE FALL OF ROME
GROWTH OF SCIENTIFIC DERMATOLOGY
DEVELOPMENT OF DERMATOLOGY AS A WORLD SPECIALTY IN THE 20TH CENTURY
REFERENCES
Chapter 2 Structure and Function of the Skin
COMPONENTS OF NORMAL HUMAN SKIN
SKIN DEVELOPMENT
EPIDERMAL AND ADNEXAL STRUCTURES
KERATINOCYTES
ECCRINE AND APOCRINE GLANDS
PILOSEBACEOUS UNIT
NAILS
MERKEL CELLS
INNATE IMMUNITY
SKIN MICROBIOME
LANGERHANS CELLS
IMMUNE SURVEILLANCE
MAST CELLS
MELANOCYTES
DESMOSOMES
ADHERENS JUNCTIONS
GAP JUNCTIONS
TIGHT JUNCTIONS
DERMAL–EPIDERMAL BASEMENT MEMBRANE
BASEMENT MEMBRANE COLLAGEN
LAMININS
HEMIDESMOSOMES
ANCHORING FIBRILS
EXTRACELLULAR MATRIX
COLLAGENS
COLLAGEN BIOSYNTHESIS
COLLAGEN BIOLOGY
COLLAGEN CROSS-LINKING
COLLAGEN DEGRADATION
ELASTIC FIBRES
ELASTIN
ELASTIN-ASSOCIATED MICROFIBRILS
PROTEOGLYCAN/GLYCOSAMINOGLYCANS
FIBROBLASTS
BLOOD VESSELS AND LYMPHATICS
SUBCUTANEOUS FAT
PHYSIOLOGICAL FUNCTIONS OF SKIN
SKIN HOMEOSTASIS
SKIN AGEING
REFERENCES
Chapter 3 Histopathology of the Skin: General Principles
INTRODUCTION
BIOPSY OF THE SKIN
LABORATORY METHODS
IMMUNOPATHOLOGY
OTHER DIAGNOSTIC METHODS
ARTEFACTS
APPROACH TO MICROSCOPIC EXAMINATION OF TISSUE SECTIONS
CONCLUSIONS
REFERENCES
Chapter 4 Diagnosis of Skin Disease
FUNDAMENTALS OF DIAGNOSIS
DISEASE DEFINITION
THE HISTORY
QUALITY OF LIFE IN DERMATOLOGY PATIENTS
EXAMINATION OF THE SKIN
DESCRIPTION OF SKIN LESIONS
CLINICAL MICROSCOPY, DERMOSCOPY AND OTHER IMAGING SYSTEMS
FINE-NEEDLE ASPIRATION OF LYMPH NODES
RADIOLOGICAL AND IMAGING EXAMINATIONS
SKIN TESTING (PRICK AND SCRATCH, INTRADERMAL AND PATCH TESTING) [1]
TELEDERMATOLOGY
MOBILE SMARTPHONE APPLICATIONS
REFERENCES
Chapter 5 Epidemiology of Skin Disease
WHAT IS EPIDEMIOLOGY AND WHY IS IT RELEVANT TO DERMATOLOGY?
THINKING IN TERMS OF POPULATIONS RATHER THAN INDIVIDUALS
HOW MUCH OF A PUBLIC HEALTH PROBLEM IS SKIN DISEASE?
WHAT DETERMINES THE FREQUENCY OF SKIN DISEASE IN POPULATIONS?
DESCRIBING THE NATURAL HISTORY AND ASSOCIATIONS OF SPECIFIC SKIN DISEASES
HEALTH SERVICES RESEARCH IN DERMATOLOGY
CONCLUSIONS
GLOSSARY OF EPIDEMIOLOGICAL TERMS
CHECKLIST FOR READING ‘EPIDEMIOLOGICAL STUDIES' IN DERMATOLOGY
RECOMMENDED FURTHER READING AND USEFUL DERMATOEPIDEMIOLOGY RESOURCES
REFERENCES
Chapter 6 Health Economics and Skin Disease
BACKGROUND
INTRODUCTION TO METHODS AND APPROACHES IN HEALTH ECONOMICS
ECONOMIC BURDEN OF DISEASE IN DERMATOLOGY
CRITICAL REFLECTION OF STUDIES ON DISEASE BURDEN
IMPACT FOR DECISION MAKING IN DERMATOLOGY PRACTICE
REFERENCES
Chapter 7 Genetics and the Skin
ADVANCES IN GENETICS
NOSOLOGY AND PRINCIPLES OF MEDICAL GENETICS
MUTATIONS AND DISEASE
MOSAICISM, LYONIZATION AND THE LINES OF BLASCHKO
GENOME SEQUENCE AND ANALYSIS OF INHERITED DISORDERS
PRENATAL DIAGNOSIS
REFERENCES
Chapter 8 Inflammation, Immunology and Allergy
CLINICAL CHARACTERISTICS OF INFLAMMATION
PHASES OF INFLAMMATION
CELLULAR COMPONENTS OF CUTANEOUS INFLAMMATION
INNATE IMMUNE DEFENCE MECHANISMS
CELLS REGULATING INNATE IMMUNITY
ADAPTIVE IMMUNE SYSTEM
MEDIATORS OF INFLAMMATION
ALLERGY
REFERENCES
Chapter 9 Photobiology
BASIC PRINCIPLES
NORMAL EFFECTS OF UVR ON SKIN
PHOTOPROTECTION
POPULATION EXPOSURE TO UVR
REFERENCES
Chapter 10 Cutaneous Response to Injury and Wound Healing
INTRODUCTION
INFLAMMATION AND THE IMMUNE RESPONSE
RE-EPITHELIALIZATION
ANGIOGENESIS
FIBROBLAST RECRUITMENT, MATRIX SYNTHESIS AND SCARRING
ABNORMAL WOUND HEALING AND SCARRING
AGE-RELATED CHANGES IN WOUND HEALING
PHYSIOLOGICAL BASIS OF TREATMENT OF WOUNDS
NOVEL THERAPIES FOR WOUND HEALING
REFERENCES
Chapter 11 Psychological and Social Impact of Long-term Dermatological Conditions
PSYCHOLOGICAL AND SOCIAL CHALLENGES OF DERMATOLOGICAL CONDITIONS
PSYCHOLOGICAL IMPACT OF DERMATOLOGICAL CONDITIONS WITH EMPHASIS ON PSORIASIS
SOCIAL IMPACT OF DERMATOLOGY CONDITIONS
SKIN CONDITIONS AND ASSOCIATED CO-MORBIDITIES
TREATMENT CHALLENGES
IMPLICATIONS OF PSYCHOLOGICAL AND SOCIAL IMPACT OF DERMATOLOGICAL CONDITIONS FOR INTEGRATED CLINICAL MANAGEMENT
REFERENCES
Chapter 12 Adverse Immunological Reactions to Drugs
INTRODUCTION
IGE-MEDIATED DRUG HYPERSENSITIVITY
T-CELL-MEDIATED DRUG HYPERSENSITIVITY
DRUGS AS HAPTENS
DRUGS AS PRO-HAPTENS
DRUGS AS NON-HAPTENS
UNDERSTANDING THE CLINICAL PHENOTYPE
REFERENCES
Chapter 13 Topical Drug Delivery
INTRODUCTION: SKIN BARRIER FUNCTION
PENETRATION PATHWAYS: MECHANISMS OF PERCUTANEOUS ABSORPTION
FACTORS DETERMINING DRUG PERMEATION INTO THE SKIN
TOPICAL DRUG FORMULATIONS USED TO TREAT DERMATOLOGICAL DISEASE
ASSESSMENT OF TOPICAL DRUG BIOAVAILABILITY AND BIOEQUIVALENCE BETWEEN FORMULATIONS
OPTIMIZATION OF DERMATOLOGICAL MEDICINES
CONCLUSIONS
REFERENCES
Chapter 14 Clinical Pharmacology
INTRODUCTION
TYPES OF DRUGS AND TERMINOLOGY
PHARMACOKINETICS
PHARMACODYNAMICS
FACTORS THAT AFFECT THERAPEUTIC OUTCOME
DRUG DEVELOPMENT AND LICENSING PROCEDURES
RESOURCES
REFERENCES
Part 2 Management
Chapter 15 Principles of Holistic Management of Skin Disease
WHAT IS HOLISTIC MANAGEMENT AND IS IT IMPORTANT?
ARE WE DOCTORS OR DISEASE MANAGEMENT TECHNICIANS?
IS DERMATOLOGY DIFFERENT?
HOW IMPORTANT IS IT TO EMPOWER PATIENTS?
CONCLUSIONS
REFERENCES
Chapter 16 Principles of Measurement and Assessment in Dermatology
MEASUREMENT OF SKIN DISEASE SEVERITY
ASSESSMENT TOOLS
OBJECTIVE METHODS FOR MEASURING SKIN PROPERTIES
MEASUREMENT OF THE IMPACT OF SKIN DISEASE
QUALITY OF LIFE MEASURES USED IN DERMATOLOGY
REFERENCES
Chapter 17 Principles of Evidence-based Dermatology
EVIDENCE-BASED MEDICINE
FORMULATING QUESTIONS AND FINDING EVIDENCE
CRITICALLY APPRAISING EVIDENCE AND APPLYING IT TO INDIVIDUAL PATIENTS
EVALUATING THE DATA IN CLINICAL RESEARCH PAPERS AND A SHORTCUT METHOD FOR READING CLINICAL RESEARCH PAPERS
REFERENCES
Chapter 18 Principles of Topical Therapy
INTRODUCTION
PRESCRIBING TOPICAL TREATMENT
HAZARDS ASSOCIATED WITH TOPICAL TREATMENT
FORMULATION OF TOPICAL MEDICAMENTS
TOPICAL TREATMENTS USED IN THE MANAGEMENT OF SKIN DISEASE
REFERENCES
Chapter 19 Principles of Systemic Therapy
INTRODUCTION
IMMUNOMODULATORY DRUGS
ANTIMICROBIAL DRUGS
REFERENCES
Chapter 20 Principles of Skin Surgery
INTRODUCTION
CRITICAL ANATOMICAL CONSIDERATIONS
EQUIPMENT AND STERILIZATION
SAFETY ASPECTS
COMPLICATIONS
LOCAL ANAESTHETICS
BIOPSY TECHNIQUES
PREOPERATIVE PREPARATION
SIMPLE EXCISION, SUTURE TECHNIQUE AND WOUND CLOSURE
DRESSINGS AND POSTOPERATIVE CARE
FLAPS (FIGURES 20.27, 20.28, 20.29, 20.30 AND 20.31)
SKIN GRAFTS
OTHER TECHNIQUES FOR FACILITATING CLOSURE
MOHS MICROGRAPHIC SURGERY
ELECTROCAUTERY AND ELECTROSURGERY [1, 2, 3]
CRYOSURGERY
CAUSTICS
INTRALESIONAL CORTICOSTEROID THERAPY [1]
INTRALESIONAL THERAPIES FOR SKIN MALIGNANCIES
MISCELLANEOUS SURGICAL PROCEDURES AND TECHNIQUES
MANAGEMENT OF SPECIFIC CONDITIONS
REFERENCES
Chapter 21 Principles of Phototherapy
INTRODUCTION
HISTORY AND BACKGROUND
ULTRAVIOLET RADIATION
INDICATIONS FOR PHOTOTHERAPY
HOW DIFFERENT THERAPIES ARE ADMINISTERED
ADVERSE EFFECTS
PATIENT SELECTION, ASSESSMENT AND EDUCATION
PATIENT AND STAFF SAFETY
PATIENT FOLLOW-UP: SKIN CANCER SURVEILLANCE
CLINICAL GOVERNANCE
HOW TO SET UP A PHOTOTHERAPY UNIT
WHAT'S NEW: DEVELOPMENTS
REFERENCES
Chapter 22 Principles of Photodynamic Therapy
WHAT IS PHOTODYNAMIC THERAPY?
HISTORY AND BACKGROUND
PHOTOSENSITIZERS USED FOR PHOTODYNAMIC THERAPY IN DERMATOLOGY
LIGHT SOURCES
INDICATIONS
CONTRAINDICATIONS
METHODOLOGY AND REGIMENS
ADVERSE EFFECTS
CLINICAL GOVERNANCE
WHAT'S NEW?
REFERENCES
Chapter 23 Principles of Cutaneous Laser Therapy
INTRODUCTION
LIGHT AND LASER LIGHT CHARACTERISTICS
CLINICAL APPLICATIONS OF LASERS AND FLASHLAMPS
REFERENCES
Chapter 24 Principles of Radiotherapy
INTRODUCTION
IONIZING RADIATION IN THE TREATMENT OF SKIN CANCER
SUPERFICIAL RADIOTHERAPY TREATMENT TECHNIQUE
MEGAVOLTAGE X-RAY THERAPY TECHNIQUE
RADIOSENSITIVITY
INDICATIONS FOR RADIOTHERAPY
ACUTE RADIATION REACTION (ACUTE RADIODERMATITIS) (FIGURES 24.18A–C AND 24.19A–C)
LATE RADIATION REACTION (CHRONIC RADIODERMATITIS) (FIGURES 24.20 AND 24.21)
TUMOUR RECURRENCE AFTER RADIOTHERAPY
RADIATION-INDUCED TUMOURS
RARE TUMOURS ASSOCIATED WITH PREVIOUS IRRADIATION
REFERENCES
Part 3 Infections and Infestations
Chapter 25 Viral Infections
POXVIRUS INFECTIONS
HERPESVIRUS INFECTIONS
POLYOMAVIRUS INFECTIONS
HUMAN PAPILLOMAVIRUS INFECTIONS
HEPATITIS INFECTIONS
PARVOVIRUS INFECTIONS
HUMAN RETROVIRUS INFECTION
VIRAL INSECT-BORNE AND HAEMORRHAGIC FEVERS
OTHER CUTANEOUS PROBLEMS ASSOCIATED WITH VIRAL INFECTIONS
REFERENCES
Chapter 26 Bacterial Infections
GRAM-POSITIVE BACTERIA
GRAM-NEGATIVE BACTERIA
ANAEROBIC BACTERIA
SPIROCHAETES AND SPIRAL BACTERIA
LEGIONELLOSIS
MISCELLANEOUS
MYCOPLASMA INFECTIONS
CHLAMYDIAE [1, 2]
RICKETTSIAL INFECTIONS
ACTINOMYCETE INFECTIONS
DERMATOSES POSSIBLY ATTRIBUTABLE TO BACTERIA
REFERENCES
Chapter 27 Mycobacterial Infections
MYCOBACTERIAL INFECTION
TUBERCULOSIS OF THE SKIN
TUBERCULIDS
NON-TUBERCULOUS (ATYPICAL) MYCOBACTERIA
REFERENCES
Chapter 28 Leprosy
REFERENCES
INTRODUCTION TO CHAPTERS 29 AND 30 Global Overview of Sexually Transmitted Infections
REFERENCES
Chapter 29 Syphilis and Congenital Syphilis
REFERENCES
Chapter 30 Other Sexually Transmitted Bacterial Diseases
REFERENCES
Chapter 31 HIV and the Skin
HIV INFECTION AND AIDS
DERMATOLOGICAL MANIFESTATIONS OF HIV INFECTION
REFERENCES
Chapter 32 Fungal Infections
SUPERFICIAL MYCOSES
SUBCUTANEOUS MYCOSES
SYSTEMIC MYCOSES
REFERENCES
Chapter 33 Parasitic Diseases
INFECTION WITH HUMAN NEMATODES
INFECTION WITH NEMATODES OF OTHER ANIMALS
INFECTION WITH TREMATODES
INFECTION WITH CESTODES
INFECTION WITH PROTOZOA
REFERENCES
Chapter 34 Arthropods
SKIN DISEASE DUE TO ARTHROPODS
CLASS INSECTA
CLASS ARACHNIDA
CLASS CHILOPODA (CENTIPEDES) AND DIPLOPODA (MILLIPEDES)
REFERENCES
Part 4 Inflammatory Dermatoses
Chapter 35 Psoriasis and Related Disorders
PLAQUE PSORIASIS
PUSTULAR PSORIASIS
PSORIATIC ARTHRITIS
REFERENCES
Chapter 36 Pityriasis Rubra Pilaris
REFERENCES
Chapter 37 Lichen Planus and Lichenoid Disorders
LICHEN PLANUS
LICHEN STRIATUS
REFERENCES
Chapter 38 Graft-versus-host Disease
ACUTE GRAFT-VERSUS-HOST DISEASE
CHRONIC GRAFT-VERSUS-HOST DISEASE
REFERENCES
Chapter 39 Eczematous Disorders
ASSESSMENT, INVESTIGATION AND MANAGEMENT OF ECZEMATOUS DISORDERS
NUMMULAR DERMATITIS
PATIENT RESOURCES
ASTEATOTIC ECZEMA
DERMATITIS AND ECZEMA OF THE HANDS
DERMATITIS AND ECZEMA OF THE LOWER LEGS
DERMATITIS AND ECZEMA OF THE EYELIDS
MISCELLANEOUS SPECIFIED ECZEMATOUS DERMATOSES
OTHER RELATED DERMATOSES
REFERENCES
Chapter 40 Seborrhoeic dermatitis
REFERENCES
Chapter 41 Atopic eczema (atopic dermatitis)
REFERENCES
Chapter 42 Urticaria
REFERENCES
Chapter 43 Recurrent Angio-oedema without Weals
REFERENCES
Chapter 44 Urticarial Vasculitis
REFERENCES
Chapter 45 Autoinflammatory Diseases Presenting in the Skin
MONOGENIC AUTOINFLAMMATORY SYNDROMES
COMPLEX AND POLYGENIC AUTOINFLAMMATORY DISEASES PRESENTING WITH URTICARIAL OR MACULOPAPULAR RASH
OTHER DISEASES IN WHICH AUTOINFLAMMATORY MECHANISMS MAY PLAY AN IMPORTANT ROLE
REFERENCES
Chapter 46 Mastocytosis
REFERENCES
Chapter 47 Reactive Inflammatory Erythemas
ERYTHEMA MULTIFORME
MISCELLANEOUS
ANNULAR ERYTHEMA OF INFANCY
ERYTHEMA ANNULARE CENTRIFUGUM
ERYTHEMA GYRATUM REPENS
ERYTHEMA MARGINATUM
NECROLYTIC MIGRATORY ERYTHEMA
EOSINOPHILIC CELLULITIS [1–5]
REFERENCES
Chapter 48 Adamantiades–Behçet disease
REFERENCES
Chapter 49 Neutrophilic Dermatoses
REFERENCES
Chapter 50 Immunobullous Diseases
INTRAEPIDERMAL IMMUNOBULLOUS DISEASES
RESOURCES
SUBEPIDERMAL IMMUNOBULLOUS DISEASES
RESOURCES
RESOURCES
REFERENCES
Chapter 51 Lupus Erythematosus
RESOURCES
RESOURCES
RESOURCES
REFERENCES
Chapter 52 Antiphospholipid syndrome
REFERENCES
Chapter 53 Dermatomyositis
REFERENCES
Chapter 54 Mixed connective tissue disease
REFERENCES
Chapter 55 Dermatological Manifestations of Rheumatoid Disease
DERMATOLOGICAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS
OTHER RHEUMATOID DISEASES
REFERENCES
Chapter 56 Systemic sclerosis (systemic scleroderma)
REFERENCES
Chapter 57 Morphoea and Allied Scarring and Sclerosing Inflammatory Dermatoses
REFERENCES
Part 5 Metabolic and Nutritional Disorders Affecting the Skin
Chapter 58 Cutaneous Amyloidoses
REFERENCES
Chapter 59 Cutaneous Mucinoses
PRIMARY MUCINOSES
REFERENCES
Chapter 60 Cutaneous Porphyrias
GENERAL CONSIDERATIONS: THEORETICAL BASIS, CLINICAL FEATURES AND LABORATORY TESTING IN PORPHYRIA
INDIVIDUAL PORPHYRIAS
REFERENCES
Chapter 61 Calcification of the Skin and Subcutaneous Tissues
REFERENCES
Chapter 62 Xanthomas and Abnormalities of Lipid Metabolism and Storage
XANTHOMAS
PRIMARY DYSLIPIDAEMIAS: HYPERCHOLESTEROLAEMIA
PRIMARY DYSLIPIDAEMIAS: COMBINED DYSLIPIDAEMIA
PRIMARY DYSLIPIDAEMIAS: HYPERTRIGLYCERIDAEMIAS
OTHER PRIMARY DYSLIPIDAEMIAS
SECONDARY DYSLIPIDAEMIAS
REFERENCES
Chapter 63 Nutritional Disorders Affecting the Skin
NUTRITION
VITAMINS
MINERALS
REFERENCES
Chapter 64 Skin Disorders in Diabetes Mellitus
REFERENCES
Part 6 Genetic Disorders Involving the Skin
Chapter 65 Inherited Disorders of Cornification
ICHTHYOSES (SEE TABLES 65.1, 65.2, 65.3, 65.4 AND 65.6)
NON-SYNDROMIC CONGENITAL ICHTHYOSES
SYNDROMIC ICHTHYOSES
MANAGEMENT OF CONGENITAL ICHTHYOSES
ACQUIRED ICHTHYOSES
PALMOPLANTAR KERATODERMA (SEE TABLES 65.9, 65.11, 65.13, 65.14 AND 65.15)
NON-SYNDROMIC PALMOPLANTAR KERATODERMA
MISCELLANEOUS DISORDERS OF KERATINIZATION
REFERENCES
Chapter 66 Inherited Acantholytic Disorders
REFERENCES
Chapter 67 Ectodermal Dysplasias
REFERENCES
Chapter 68 Inherited Hair Disorders
HYPERTRICHOSES
GENERALIZED HYPERTRICHOSES
ATRICHIAS
HYPOTRICHOSES
HAIR SHAFT STRUCTURAL ABNORMALITIES
OVERALL APPROACH TO THE DIAGNOSIS OF GENOTRICHOSES
REFERENCES
Chapter 69 Genetic Defects of Nails and Nail Growth
REFERENCES
Chapter 70 Genetic Disorders of Pigmentation
HYPOPIGMENTATION DISORDERS
HYPERPIGMENTATION DISORDERS
DYSCHROMATOSES
REFERENCES
Chapter 71 Genetic Blistering Diseases
REFERENCES
Chapter 72 Genetic Disorders of Collagen, Elastin and Dermal Matrix
INHERITED DISORDERS OF COLLAGEN
INHERITED DISORDERS OF ELASTIC FIBRES
INFANTILE STIFF SKIN SYNDROMES
PREMATURE AGEING SYNDROMES
DISORDERS OF ECTOPIC CALCIFICATION AND ABNORMAL MINERALIZATION
MISCELLANEOUS DERMAL DISORDERS
REFERENCES
Chapter 73 Disorders Affecting Cutaneous Vasculature
CAPILLARY DISORDERS
ARTERIOVENOUS DISORDERS
VENOUS DISORDERS
LYMPHATIC DISORDERS
REFERENCES
Chapter 74 Genetic Disorders of Adipose Tissue
REFERENCES
Chapter 75 Congenital Naevi and Other Developmental Abnormalities Affecting the Skin
CONGENITAL NAEVI
OTHER DEVELOPMENTAL ABNORMALITIES AFFECTING THE SKIN
REFERENCES
Chapter 76 Chromosomal Disorders
AUTOSOMAL CHROMOSOME DEFECTS
SEX CHROMOSOME DEFECTS
CHROMOSOMAL MOSAICISM
REFERENCES
Chapter 77 Poikiloderma Syndromes
REFERENCES
Chapter 78 DNA Repair Disorders with Cutaneous Features
OTHER DISORDERS
REFERENCES
Chapter 79 Syndromes with Premature Ageing
REFERENCES
Chapter 80 Hamartoneoplastic Syndromes
REFERENCES
Chapter 81 Inherited Metabolic Diseases
LYSOSOMAL STORAGE DISORDERS
MITOCHONDRIAL RESPIRATORY CHAIN DISORDERS
CONGENITAL DISORDERS OF GLYCOSYLATION
DISORDERS OF AMINO ACID METABOLISM AND TRANSPORT
DISORDERS OF CHOLESTEROL SYNTHESIS
OTHER METABOLIC DISORDERS
REFERENCES
Chapter 82 Inherited Immunodeficiency
REFERENCES
Part 7 Psychological, Sensory and Neurological Disorders and the Skin
Chapter 83 Pruritus, Prurigo and Lichen Simplex
REFERENCES
Chapter 84 Mucocutaneous Pain Syndromes
REFERENCES
Chapter 85 Neurological Conditions Affecting the Skin
REFERENCES
Chapter 86 Psychodermatology and Psychocutaneous Disease
DELUSIONAL BELIEFS
OBSESSIVE AND COMPULSIVE BEHAVIOUR
EATING DISORDERS
PSYCHOGENIC ITCH
FACTITIOUS SKIN DISEASE
DELIBERATE SELF-HARM
OTHER PSYCHODERMATOLOGY AND PSYCHOCUTANEOUS DISEASES
REFERENCES
Part 8 Skin Disorders Associated with Specific Cutaneous Structures
Chapter 87 Acquired Disorders of Epidermal Keratinization
REFERENCES
Chapter 88 Acquired Pigmentary Disorders
SKIN PIGMENTATION AND THE MELANOCYTE
ACQUIRED HYPERMELANOSIS
ACQUIRED HYPOMELANOSIS (FIGURE 88.33)
NON-MELANIN PIGMENTATION
REFERENCES
Chapter 89 Acquired Disorders of Hair
HAIR BIOLOGY
APPROACH TO THE PATIENT WITH HAIR LOSS
NON-SCARRING DISORDERS OF HAIR GROWTH
SCARRING DISORDERS OF HAIR GROWTH
OTHER DISORDERS OF HAIR GROWTH
ABNORMALITIES OF THE HAIR SHAFT
EXCESSIVE GROWTH OF HAIR
HAIR PIGMENTATION
HAIR COSMETICS
REFERENCES
Chapter 90 Acne
REFERENCES
Chapter 91 Rosacea
FACIAL DERMATOSES WITH AN UNCERTAIN NOSOLOGICAL RELATIONSHIP TO ROSACEA
REFERENCES
Chapter 92 Hidradenitis Suppurativa
REFERENCES
Chapter 93 Other Acquired Disorders of the Pilosebaceous Unit
REFERENCES
Chapter 94 Disorders of the Sweat Glands
ECCRINE GLANDS
DISORDERS OF ECCRINE SWEAT GLANDS
APOCRINE GLANDS
DISORDERS OF APOCRINE SWEAT GLANDS
REFERENCES
Chapter 95 Acquired Disorders of the Nails and Nail Unit
ANATOMY AND BIOLOGY OF THE NAIL UNIT
NAIL SIGNS AND THEIR SIGNIFICANCE
TRAUMATIC NAIL DISORDERS
TUMOURS UNDER OR ADJACENT TO THE NAIL
PERIONYCHIAL DISORDERS
DERMATOSES AFFECTING THE NAILS
NAILS IN CHILDHOOD AND OLD AGE
IMAGING OF THE NAIL
NAIL SURGERY
THE NAIL AND COSMETICS
REFERENCES
Chapter 96 Acquired Disorders of Dermal Connective Tissue
CHANGES IN DERMAL CONNECTIVE TISSUE DUE TO AGEING AND PHOTODAMAGE
OTHER CAUSES OF CUTANEOUS ATROPHY
DISORDERS OF ELASTIC FIBRE DEGRADATION
ACQUIRED DISORDERS OF ELASTIC TISSUE DEPOSITION
FIBROMATOSES AND OTHER CAUSES OF DIFFUSE FIBROSIS
ABNORMAL FIBROTIC RESPONSES TO SKIN INJURY
PERFORATING DERMATOSES
REFERENCES
Chapter 97 Granulomatous Disorders of the Skin
REFERENCES
Chapter 98 Sarcoidosis
SPECIFIC FORMS OF CUTANEOUS SARCOIDOSIS
SPECIAL LOCATIONS OF SPECIFIC CUTANEOUS LESIONS
NON-SPECIFIC LESIONS
CUTANEOUS SARCOID REACTION
REFERENCES
Chapter 99 Panniculitis
ANATOMY AND PHYSIOLOGY OF SUBCUTANEOUS FAT
PANNICULITIS
REFERENCES
Chapter 100 Other Acquired Disorders of Subcutaneous Fat
ACQUIRED LIPODYSTROPHY
FAT HYPERTROPHY
SUBCUTANEOUS LIPOMATOSIS
LIPOEDEMA
MISCELLANEOUS DISORDERS OF SUBCUTANEOUS FAT
REFERENCES
Part 9 Vascular Disorders Involving the Skin
Chapter 101 Purpura
PURPURA DUE TO THROMBOCYTOPENIA OR PLATELET DEFECTS
NON-THROMBOCYTOPENIC VASCULAR CAUSES OF PURPURA AND SYNDROMES OF PRIMARY ECCHYMOTIC HAEMORRHAGE
PIGMENTED PURPURIC DERMATOSES
DISORDERS OF CUTANEOUS MICROVASCULAR OCCLUSION
REFERENCES
Chapter 102 Cutaneous Vasculitis
SINGLE-ORGAN SMALL-VESSEL VASCULITIS
SMALL-VESSEL IMMUNE COMPLEX-ASSOCIATED VASCULITIS
SMALL-VESSEL ANCA-ASSOCIATED VASCULITIS
MEDIUM-VESSEL VASCULITIS
LARGE-VESSEL VASCULITIS
REFERENCES
Chapter 103 Dermatoses Resulting from Disorders of the Veins and Arteries
ARTERIAL AND ARTERIOLAR DISORDERS
NEUROVASCULAR DISORDERS
TELANGIECTASES
MALFORMATIONS
VENOUS DISORDERS
REFERENCES
Chapter 104 Ulceration Resulting from Disorders of the Veins and Arteries
REFERENCES
Chapter 105 Disorders of the Lymphatic Vessels
CLINICAL PRESENTATIONS OF LYMPHATIC DYSFUNCTION
COMPLICATIONS OF LYMPHOEDEMA
IMAGING OF THE LYMPHATIC SYSTEM
LYMPHOEDEMA MANAGEMENT
REFERENCES
Chapter 106 Flushing and Blushing
REFERENCES
Part 10 Skin Disorders Associated with Specific Sites, Sex and Age
Chapter 107 Dermatoses of the Scalp
SCALING DISORDERS OF THE SCALP
SECONDARY CICATRICIAL ALOPECIA
THICKENED SCALP DISORDERS
TUMOURS OF THE SCALP
INFECTIONS OF THE SCALP
PUSTULAR CONDITIONS OF THE SCALP
OTHER SCALP DISORDERS
REFERENCES
Chapter 108 Dermatoses of the External Ear
REFERENCES
Chapter 109 Dermatoses of the Eye, Eyelids and Eyebrows
SKIN DISEASES AFFECTING THE EYE AND EYELIDS
INFECTIONS
VIRAL INFECTIONS
BACTERIAL INFECTIONS
MYCOBACTERIAL INFECTIONS
TREPONEMAL INFECTIONS
PARASITIC INFECTIONS
OTHER INFECTIONS
OTHER DISORDERS
REFERENCES
Chapter 110 Dermatoses of the Oral Cavity and Lips
BIOLOGY OF THE MOUTH
EXAMINATION OF THE MOUTH AND PERIORAL REGION
DISORDERS AFFECTING THE ORAL MUCOSA OR LIPS
GENETIC DISORDERS AFFECTING THE ORAL MUCOSA OR LIPS
ORAL MANIFESTATIONS OF SYSTEMIC DISEASES
REFERENCES
Chapter 111 Dermatoses of the Male Genitalia
TRAUMA AND ARTEFACT
INFLAMMATORY DERMATOSES
MISCELLANEOUS INFLAMMATORY DERMATOSES
NON-SEXUALLY TRANSMITTED INFECTIONS
DERMATOLOGICAL ASPECTS OF SEXUALLY TRANSMITTED DISEASE
BENIGN TUMOURS
PRE-CANCEROUS DERMATOSES AND CARCINOMA IN SITU
SQUAMOUS CARCINOMA AND OTHER MALIGNANT NEOPLASMS
MISCELLANEOUS CUTANEOUS MALE GENITAL CONDITIONS
REFERENCES
Chapter 112 Dermatoses of the Female Genitalia
CONGENITAL ABNORMALITIES
GENODERMATOSES
INFLAMMATORY DERMATOSES OF THE VULVA
ULCERATIVE AND BULLOUS DISORDERS
PIGMENTARY DISORDERS
VULVAL OEDEMA
NON-SEXUALLY TRANSMITTED INFECTIONS
DIAGNOSIS OF VAGINAL DISCHARGE
BACTERIAL INFECTIONS
FUNGAL INFECTIONS
VIRAL INFECTIONS
BENIGN TUMOURS
PRE-MALIGNANT CONDITIONS
MALIGNANT NEOPLASMS
PAIN DISORDERS
TRAUMATIC LESIONS
MISCELLANEOUS
REFERENCES
Chapter 113 Dermatoses of Perineal and Perianal Skin
PERIANAL ITCHING
INFLAMMATORY DERMATOSES
DRUG REACTIONS
INFECTIONS
BACTERIAL INFECTIONS
OTHER BACTERIAL INFECTIONS
FUNGAL INFECTIONS
VIRAL INFECTIONS
HELMINTH INFECTIONS
MISCELLANEOUS INFECTIONS
OTHER DISEASES AND INFECTIONS
REFERENCES
Chapter 114 Cutaneous Complications of Stomas and Fistulae
REFERENCES
Chapter 115 Dermatoses of Pregnancy
PHYSIOLOGICAL SKIN CHANGES IN PREGNANCY
SKIN INFECTIONS
AUTOIMMUNE SKIN DISEASES
SKIN TUMOURS
INFLAMMATORY SKIN DISEASES
ITCHING
SPECIFIC DERMATOSES
GENERAL GUIDANCE ON SAFE TREATMENTS IN PREGNANCY
REFERENCES
Chapter 116 Dermatoses of the Neonate
INTRODUCTION
SKIN DISORDERS IN THE NEONATE
COMPLICATIONS OF PREMATURITY
COMPLICATIONS OF MEDICAL PROCEDURES ON THE FETUS AND NEONATE
ATROPHIC LESIONS OF NEONATES
DISORDERS CAUSED BY TRANSPLACENTAL TRANSFER/MATERNAL MILK
DISORDERS OF SUBCUTANEOUS FAT
MISCELLANEOUS DISORDERS
INFECTIONS
REFERENCES
Chapter 117 Dermatoses and Haemangiomas of Infancy
INFANTILE DERMATOSES
INFLAMMATORY CONDITIONS
INFECTIVE CONDITIONS
REACTIVE CONDITIONS
DEVELOPMENTAL/GENETIC CONDITIONS
MISCELLANEOUS CONDITIONS
INFANTILE AND CONGENITAL HAEMANGIOMAS
APPENDIX 117.1 PROTOCOL FOR THE USE OF PROPRANOLOL IN TREATING INFANTILE HAEMANGIOMAS
REFERENCES
Part 11 Skin Disorders Caused by External Agents
Chapter 118 Benign Cutaneous Adverse Reactions to Drugs
REFERENCES
Chapter 119 Severe Cutaneous Adverse Reactions to Drugs
REFERENCES
Chapter 120 Cutaneous Side Effects of Chemotherapy and Radiotherapy
REFERENCES
Chapter 121 Dermatoses Induced by Illicit Drugs
REFERENCES
Chapter 122 Dermatological Manifestations of Metal Poisoning
REFERENCES
Chapter 123 Mechanical Injury to the Skin
OVERVIEW OF SKIN INJURY
BIOMECHANICAL CONSIDERATIONS
EFFECTS OF FRICTION
OTHER REACTIONS TO MECHANICAL INJURY
REACTIONS TO FOREIGN BODIES
OTHER SKIN INJURIES
REFERENCES
Chapter 124 Pressure Injury and Pressure Ulcers
REFERENCES
Chapter 125 Cutaneous Reactions to Cold and Heat
PHYSIOLOGICAL REACTIONS TO COLD
DISEASES CAUSED OR AGGRAVATED BY COLD
PHYSIOLOGICAL REACTIONS TO HEAT AND INFRARED RADIATION
DISEASES CAUSED BY HEAT AND INFRARED RADIATION
REFERENCES
Chapter 126 Burns and Heat Injury
REFERENCES
Chapter 127 Cutaneous Photosensitivity Diseases
IDIOPATHIC (IMMUNOLOGICAL) PHOTODERMATOSES
DRUG- AND CHEMICAL-INDUCED PHOTOSENSITIVITY
PHOTOAGGRAVATED DERMATOSES
CLINICAL ASSESSMENT AND MANAGEMENT OF A PATIENT WITH SUSPECTED PHOTOSENSITIVITY
REFERENCES
Chapter 128 Allergic Contact Dermatitis
REFERENCES
Chapter 129 Irritant Contact Dermatitis
REFERENCES
Chapter 130 Occupational Dermatology
REFERENCES
Chapter 131 Stings and Bites
STINGS
BITES
REFERENCES
Part 12 Neoplastic, Proliferative and Infiltrative Disorders Affecting the Skin
Chapter 132 Benign Melanocytic Proliferations and Melanocytic Naevi
LENTIGINES
MUCOSAL MELANOTIC LESIONS
DERMAL MELANOCYTIC LESIONS
CONGENITAL MELANOCYTIC NAEVI
COMMON ACQUIRED NAEVI
NAEVI IN UNUSUAL SITES
NAEVI WITH UNUSUAL MORPHOLOGY
OTHER NAEVI
RESOURCES
PATIENT RESOURCES
PATIENT RESOURCES
REFERENCES
Chapter 133 Benign Keratinocytic Acanthomas and Proliferations
BENIGN KERATINOCYTIC ACANTHOMAS
OTHER BENIGN PROLIFERATIONS
REFERENCES
SEBORRHOEIC KERATOSIS
STUCCO KERATOSIS
DERMATOSIS PAPULOSA NIGRA
WARTY DYSKERATOMA
CLEAR CELL ACANTHOMAS
LICHENOID KERATOSIS
BENIGN SKIN TAGS
PSEUDOEPITHELIOMATOUS HYPERPLASIA
Chapter 134 Cutaneous Cysts
REFERENCES
EPIDERMOID CYSTS
TRICHILEMMAL CYSTS
STEATOCYSTOMA MULTIPLEX
Chapter 135 Lymphocytic Infiltrates
REFERENCES
PSEUDOLYMPHOMA
PITYRIASIS LICHENOIDES
PARAPSORIASIS
LYMPHOCYTOMA CUTIS
JESSNER'S LYMPHOCYTIC INFILTRATE
Chapter 136 Cutaneous Histiocytoses
DISORDERS OF DENDRITIC CELLS
RESOURCES
DISORDERS OF NON-DENDRITIC CELLS
NON-LANGERHANS CELL HISTIOCYTOSES
DENDRITIC CELL ORIGIN
NON-DENDRITIC CELL ORIGIN
MALIGNANT HISTIOCYTOSES
RESOURCES
FURTHER INFORMATION
FURTHER INFORMATION
REFERENCES
ONTOGENY OF HISTIOCYTES
FUNCTION OF HISTIOCYTES
CLASSIFICATION OF HISTIOCYTOSES
ONTOGENY OF HISTIOCYTES
FUNCTION OF HISTIOCYTES
CLASSIFICATION OF HISTIOCYTOSES
LANGERHANS CELL HISTIOCYTOSIS
HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
JUVENILE XANTHOGRANULOMA
BENIGN CEPHALIC HISTIOCYTOSIS
GENERALIZED ERUPTIVE HISTIOCYTOSIS
PAPULAR XANTHOMA
PROGRESSIVE NODULAR HISTIOCYTOSIS
XANTHOMA DISSEMINATUM
DIFFUSE PLANE XANTHOMATOSIS
ERDHEIM–CHESTER DISEASE
RETICULOHISTIOCYTOMA
FAMILIAL SEA-BLUE HISTIOCYTOSIS
HEREDITARY PROGRESSIVE MUCINOUS HISTIOCYTOSIS
MALAKOPLAKIA
NECROBIOTIC XANTHOGRANULOMA
MULTICENTRIC RETICULOHISTIOCYTOSIS
SINUS HISTIOCYTOSIS WITH MASSIVE LYMPHADENOPATHY
MALIGNANT HISTIOCYTOSIS
TRUE HISTIOCYTIC LYMPHOMA
HISTIOCYTIC SARCOMA
Chapter 137 Soft-tissue Tumours and Tumour-like Conditions
FIBROUS AND MYOFIBROBLASTIC TUMOURS
FIBROHISTIOCYTIC TUMOURS
VASCULAR TUMOURS
MALIGNANT VASCULAR TUMOURS
LYMPHATIC TUMOURS
TUMOURS OF PERIVASCULAR CELLS
PERIPHERAL NEUROECTODERMAL TUMOURS
TUMOURS OF MUSCLE
SKELETAL MUSCLE TUMOURS
TUMOURS OF FAT CELLS
TUMOURS OF UNCERTAIN HISTOGENESIS
REFERENCES
Chapter 138 Tumours of Skin Appendages
HAIR FOLLICLE TUMOURS
EXTERNAL ROOT SHEATH TUMOURS
HAMARTOMAS AND HAIR GERM TUMOURS AND CYSTS
HAIR MATRIX TUMOURS
LESIONS OF HAIR FOLLICLE MESENCHYME
SEBACEOUS GLAND TUMOURS [1–6]
APOCRINE GLAND TUMOURS [1]
ECCRINE GLAND HAMARTOMAS AND TUMOURS
ECCRINE OR APOCRINE/FOLLICULAR TUMOURS
SWEAT GLAND CARCINOMAS, INCLUDING DUCTAL APOCRINE/FOLLICULAR CARCINOMAS
MISCELLANEOUS TUMOURS
REFERENCES
Chapter 139 Kaposi Sarcoma
REFERENCES
Chapter 140 Cutaneous Lymphomas
PRIMARY CUTANEOUS T-CELL LYMPHOMAS
PRIMARY CUTANEOUS CD30+ LYMPHOPROLIFERATIVE DISORDERS
PRIMARY CUTANEOUS PERIPHERAL T-CELL LYMPHOMA (UNSPECIFIED)
PRIMARY CUTANEOUS B-CELL LYMPHOMAS
SECONDARY CUTANEOUS B-CELL LYMPHOMAS
SECONDARY CUTANEOUS T-CELL LYMPHOMAS
OTHER DISORDERS
REFERENCES
Chapter 141 Basal Cell Carcinoma
BASAL CELL CARCINOMA
FIBROEPITHELIAL BASAL CELL CARCINOMA
NAEVOID BASAL CELL CARCINOMA SYNDROME
BAZEX–DUPRÉ–CHRISTOL SYNDROME
REFERENCES
Chapter 142 Squamous Cell Carcinoma and its Precursors
LESIONS WITH UNCERTAIN OR UNPREDICTABLE MALIGNANT POTENTIAL
IN SITU CARCINOMA OF THE SKIN
RESOURCES
SQUAMOUS CELL CARCINOMA OF THE SKIN
RESOURCES
KERATOACANTHOMAS AND ASSOCIATED SYNDROMES
RESOURCES
RESOURCES
REFERENCES
Chapter 143 Melanoma
MELANOMA CLINICOPATHOLOGY
MELANOMA SURGERY
SYSTEMIC TREATMENT OF MELANOMA
MELANOMA CLINICOPATHOLOGY
REFERENCES
MELANOMA SURGERY: BIOPSIES, WIDE RESECTION AND SENTINEL LYMPH NODE SAMPLING
REFERENCES
SYSTEMIC TREATMENT OF MELANOMA
REFERENCES
Chapter 144 Dermoscopy of Melanoma and Naevi
REFERENCES
Chapter 145 Merkel cell carcinoma
REFERENCES
Chapter 146 Skin Cancer in the Immunocompromised Patient
REFERENCES
Part 13 Systemic Disease and the Skin
Chapter 147 Cutaneous Markers of Internal Malignancy
INTRODUCTION
GENODERMATOSES ASSOCIATED WITH INTERNAL MALIGNANCIES
IMMUNODEFICIENCY AND NEOPLASIA SYNDROMES (SEE ALSO CHAPTER 82)
PARANEOPLASTIC PHENOMENA INVOLVING THE SKIN
ACANTHOTIC AND ICHTHYOTIC EPIDERMAL DISORDERS
OTHER EPIDERMAL DISORDERS
PARANEOPLASTIC PIGMENTATION
HAIR, NAILS AND SKIN APPENDAGES
DERMATOSES ASSOCIATED WITH INTERNAL MALIGNANCIES
CONNECTIVE TISSUE AND RHEUMATOLOGICAL DISORDERS
BULLOUS DISORDERS ASSOCIATED WITH INTERNAL MALIGNANCY
OTHER BLISTERING DISORDERS
DEPOSITION DISORDERS
OTHER DERMATOLOGICAL DISORDERS
VASCULAR DISORDERS ASSOCIATED WITH INTERNAL MALIGNANCY
CANCER-ASSOCIATED THROMBOSIS
VENOUS OR LYMPHATIC OBSTRUCTION
REFERENCES
INTRODUCTION
MULTISYSTEM AND HAEMATOPOIETIC TUMOURS THAT INVOLVE THE SKIN
TUMOUR SPREAD FROM ADJACENT AND DISTANT TISSUES
DIRECT TUMOUR SPREAD AND INVASION
CUTANEOUS METASTASIS
PAGET DISEASE
GENODERMATOSES ASSOCIATED WITH INTERNAL MALIGNANCIES
HOWEL–EVANS SYNDROME
NAEVOID BASAL CELL CARCINOMA SYNDROME
FAMILIAL MELANOMA SYNDROME
MELANOMA–ASTROCYTOMA SYNDROME
XERODERMA PIGMENTOSUM
VON HIPPEL–LINDAU DISEASE
NEUROFIBROMATOSIS TYPES 1 AND 2
TUBEROUS SCLEROSIS COMPLEX
MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES
CARNEY COMPLEX
PTEN HAMARTOMA TUMOUR SYNDROME
SEBACEOUS TUMOURS, KERATOACANTHOMAS AND VISCERAL MALIGNANCY
HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA SYNDROME
BLOOM, ROTHMUND–THOMSON AND WERNER SYNDROMES
BLOOM SYNDROME
ROTHMUND–THOMSON SYNDROME
WERNER SYNDROME
IMMUNODEFICIENCY AND NEOPLASIA SYNDROMES
WISKOTT–ALDRICH SYNDROME
CHEDIAK-HIGASHI SYNDROME, ATAXIA-TELANGIECTASIA, DYSKERATOSIS CONGENITAL, FANCONI ANAEMIA
PARANEOPLASTIC PHENOMENA INVOLVING THE SKIN
ACANTHOTIC, EPIDERMAL AND ICHTHYOTIC DISORDERS
ACANTHOSIS NIGRICANS
ACANTHOSIS PALMARIS
SIGN OF LESER–TRéLAT
FLORID CUTANEOUS PAPILLOMATOSIS
ACQUIRED ICHTHYOSIS AND OTHER EPIDERMAL DISORDERS
PARANEOPLASTIC PIGMENTATION
HAIR, NAILS AND SKIN APPENDAGES
PARANEOPLASTIC HYPERTRICHOSIS LANUGINOSA ACQUISITA
CLUBBING OF NAILS
HYPERHIDROSIS
DERMATOSES ASSOCIATED WITH INTERNAL MALIGNANCIES
ACROKERATOSIS PARANEOPLASTICA
MIGRATORY ERYTHEMAS
CONNECTIVE TISSUE AND RHEUMATOLOGICAL DISORDERS
DERMATOMYOSITIS
LUPUS ERYTHEMATOSUS
SCLERODERMA, FASCIITIS, PANNICULITIS AND SIMILAR SCLERODERMOID CONDITIONS
BULLOUS DISORDERS ASSOCIATED WITH INTERNAL MALIGNANCY
PARANEOPLASTIC PEMPHIGUS
BULLOUS PEMPHIGOID, PEMPHIGUS
OTHER BLISTERING DISORDERS
DEPOSITION DISORDERS
OTHER DERMATOLOGICAL DISORDERS
VASCULAR DISORDERS ASSOCIATED WITH INTERNAL MALIGNANCY
RAYNAUD PHENOMENON AND DIGITAL ISCHAEMIA, ERYTHROMELALGIA, PALMAR ERYTHEMA, VASCULITIS, CHILBLAIN-LIKE LESIONS
FLUSHING
CANCER-ASSOCIATED THROMBOSIS
VENOUS AND LYMPHATIC OBSTRUCTION
Chapter 148 The Skin and Disorders of the Haematopoietic and Immune Systems
SKIN DISORDERS CAUSED BY INFILTRATION OF THE SKIN WITH NEOPLASTIC CELLS
IMMUNOGLOBULIN DEPOSITION DISORDERS OF THE SKIN
PARANEOPLASTIC CONDITIONS STRONGLY ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCIES
PARANEOPLASTIC CONDITIONS OCCASIONALLY ASSOCIATED WITH HAEMATOLOGICAL NEOPLASMS
SYNDROMES ASSOCIATED WITH HAEMATOLOGICAL MALIGNANCIES AND INVOLVING THE SKIN
SKIN INVOLVEMENT IN IDIOPATHIC LYMPHADENOPATHIES
SKIN MANIFESTATION IN PRIMARY IMMUNODEFICIENCIES
SKIN MANIFESTATIONS OF ACQUIRED IMMUNODEFICIENCIES
ANAEMIAS AND HAEMOGLOBINOPATHIES
TRANSFUSION REACTIONS
REFERENCES
Chapter 149 The Skin and Endocrine Disorders
REFERENCES
Chapter 150 The Skin and Disorders of the Heart
HEREDITARY SYNDROMES
CARDIAC INVOLVEMENT IN DERMATOSES OR SYSTEMIC DISEASES WITH SKIN FEATURES
REFERENCES
Chapter 151 The Skin and Disorders of the Respiratory System
INTRODUCTION
ALLERGIC DISORDERS
AUTOIMMUNE DISORDERS
VASCULITIS
INFECTIONS
CONGENITAL AND INHERITED DISORDERS/GENETIC SYNDROMES
NEUTROPHILIC DERMATOSES
OTHER SYSTEMIC DISEASES
MISCELLANEOUS DISORDERS
REFERENCES
Chapter 152 The Skin and Disorders of the Digestive System
OESOPHAGUS, STOMACH AND INTESTINE
LIVER AND GALL BLADDER
PANCREATIC DISEASE
DERMATOLOGICAL MANIFESTATIONS OF OTHER DISORDERS INVOLVING THE DIGESTIVE SYSTEM
REFERENCES
Chapter 153 The Skin and Disorders of the Kidney and Urinary Tract
INTRODUCTION
HEREDITARY SYNDROMES WITH SKIN AND RENAL INVOLVEMENT
SKIN SYMPTOMS AND SIGNS ASSOCIATED WITH RENAL DISORDERS
ACQUIRED DISORDERS WITH SKIN AND RENAL INVOLVEMENT
SKIN DISORDERS THAT MAY AFFECT THE KIDNEY AND URINARY TRACT
REFERENCES
Chapter 154 The Skin and Disorders of the Musculoskeletal System
INFECTIVE ARTHROPATHIES
INFLAMMATORY ARTHROPATHIES
OSTEOARTHRITIS
METABOLIC DISORDERS WITH MUSCULOSKELETAL AND CUTANEOUS INVOLVEMENT
AUTOINFLAMMATORY DISORDERS
INFLAMMATORY CHONDROPATHIES
MISCELLANEOUS DISORDERS INVOLVING THE SKIN AND MUSCULOSKELETAL SYSTEM
CUTANEOUS ADVERSE REACTIONS TO ANTIRHEUMATIC THERAPIES (SEE ALSO CHAPTERS 120 AND 121)
REFERENCES
INTRODUCTION
INFECTIVE ARTHROPATHIES
REACTIVE ARTHRITIS
VIRAL ARTHROPATHIES
BACTERIAL ARTHROPATHIES
OTHER INFECTIVE ARTHROPATHIES
SERONEGATIVE ARTHRITIS AND SPONDYLITIS
RHEUMATOID ARTHRITIS
ATROPHIC SKIN WITH RHEUMATOID ARTHRITIS
INFLAMMATORY ARTHROPATHIES
RHEUMATOID ARTHRITIS
RHEUMATOID NODULES
RHEUMATOID VASCULITIS AND CUTANEOUS ULCERATION
RHEUMATOID NEUTROPHILIC DERMATOSIS
FIBROBLASTIC RHEUMATISM
SARCOIDOSIS
HEBERDEN AND BOUCHARD NODES
HAEMOCHROMATOSIS
ALKAPTONURIA
METABOLIC DISORDERS WITH MUSCULOSKELETAL AND CUTANEOUS INVOLVEMENT
GOUT
AUTOINFLAMMATORY DISORDERS
ACNE
HIDRADENITIS SUPPURATIVA
INFLAMMATORY CHONDROPATHIES
RELAPSING POLYCHONDRITIS
MAGIC SYNDROME
MASTOCYTOSIS
MISCELLANEOUS DISORDERS INVOLVING THE SKIN AND MUSCULOSKELETAL SYSTEM
PACHYDERMOPERIOSTOSIS
INTERSTITIAL GRANULOMATOUS DERMATOSIS
INTRALYMPHATIC HISTIOCYTOSIS
CUTANEOUS ADVERSE REACTIONS TO ANTIRHEUMATIC THERAPIES
INTRODUCTION
INFECTIVE ARTHROPATHIES
REACTIVE ARTHRITIS
VIRAL ARTHROPATHIES
BACTERIAL ARTHROPATHIES
OTHER INFECTIVE ARTHROPATHIES
SERONEGATIVE ARTHRITIS AND SPONDYLITIS
RHEUMATOID ARTHRITIS
ATROPHIC SKIN WITH RHEUMATOID ARTHRITIS
INFLAMMATORY ARTHROPATHIES
RHEUMATOID ARTHRITIS
RHEUMATOID NODULES
RHEUMATOID VASCULITIS AND CUTANEOUS ULCERATION
RHEUMATOID NEUTROPHILIC DERMATOSIS
FIBROBLASTIC RHEUMATISM
SARCOIDOSIS
HEBERDEN AND BOUCHARD NODES
HAEMOCHROMATOSIS
ALKAPTONURIA
RHEUMATOID ARTHRITIS
RHEUMATOID NODULES
RHEUMATOID VASCULITIS AND CUTANEOUS ULCERATION
RHEUMATOID NEUTROPHILIC DERMATOSIS
FIBROBLASTIC RHEUMATISM
SARCOIDOSIS
HEBERDEN AND BOUCHARD NODES
HAEMOCHROMATOSIS
ALKAPTONURIA
RHEUMATOID NODULES
RHEUMATOID VASCULITIS AND CUTANEOUS ULCERATION
RHEUMATOID NEUTROPHILIC DERMATOSIS
FIBROBLASTIC RHEUMATISM
SARCOIDOSIS
HEBERDEN AND BOUCHARD NODES
HAEMOCHROMATOSIS
ALKAPTONURIA
METABOLIC DISORDERS WITH MUSCULOSKELETAL AND CUTANEOUS INVOLVEMENT
GOUT
GOUT
AUTOINFLAMMATORY DISORDERS
ACNE
HIDRADENITIS SUPPURATIVA
ACNE
HIDRADENITIS SUPPURATIVA
INFLAMMATORY CHONDROPATHIES
RELAPSING POLYCHONDRITIS
MAGIC SYNDROME
MASTOCYTOSIS
RELAPSING POLYCHONDRITIS
MAGIC SYNDROME
MASTOCYTOSIS
MISCELLANEOUS DISORDERS INVOLVING THE SKIN AND MUSCULOSKELETAL SYSTEM
PACHYDERMOPERIOSTOSIS
INTERSTITIAL GRANULOMATOUS DERMATOSIS
INTRALYMPHATIC HISTIOCYTOSIS
PACHYDERMOPERIOSTOSIS
INTERSTITIAL GRANULOMATOUS DERMATOSIS
INTRALYMPHATIC HISTIOCYTOSIS
CUTANEOUS ADVERSE REACTIONS TO ANTIRHEUMATIC THERAPIES
Part 14 Aesthetic Dermatology
Chapter 155 Skin Ageing
REFERENCES
Chapter 156 Cosmeceuticals
REFERENCES
Chapter 157 Soft Tissue Augmentation (Fillers)
REFERENCES
Chapter 158 Aesthetic Uses of Botulinum Toxins
REFERENCES
Chapter 159 Chemical Peels
REFERENCES
Chapter 160 Lasers and Energy-based Devices
REFERENCES
Index
EULA