Therapy for Severe Psoriasis

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Foreword
Preface

Chapter 1. Overview of Psoriasis
Key points
Epidemiology
Age of onset
Development of a lesion
T cells
Macrophages and dendritic cells
Neutrophils
Uninvolved psoriatic skin
Clinical findings
Cutaneous lesions
Related physical findings
Psoriatic arthritis
Laboratory tests
Complications
Modifying factors
Treatment
Topical therapies
Corticosteroids
Vitamin D3 and analogues
Tazarotene
Topical calcineurin inhibitors
Salicylic acid
Bland emollients
Phototherapy
Oral agents
Biologic therapy

Chapter 2. Ultraviolet B Phototherapy
Key points
Introduction
Targeted phototherapy
Tanning beds
Indications
Mechanism of action
Efficacy
Targeted phototherapy
Tanning beds
Safety
Targeted phototherapy
Tanning beds
Precautions
Monitoring
Targeted phototherapy
Vaccinations
Summary

Chapter 3. Psoralen-Ultraviolet Light A Therapy
Key points
Introduction
Mechanism of action
Efficacy
Dosing
Safety
Precautions
Monitoring
Vaccination
Summary

Chapter 4. Methotrexate
Key points
Introduction
Mechanism of action
Efficacy
Smaller studies
Efficacy in reduction of immunogenicity
Efficacy in psoriatic arthritis
Safety
Precautions
Monitoring
Vaccinations
Summary and recommendations

Chapter 5. Acitretin
Key points
Introduction
Mechanism of action
Efficacy
Safety
Precautions
Monitoring
Vaccinations
Summary

Chapter 6. Cyclosporine
Key points
Introduction
Mechanism of action
Efficacy
Efficacy in psoriatic arthritis
Safety
Precautions
Monitoring
Vaccinations
Summary and recommendations

Chapter 7. Apremilast
Key points
Introduction
Mechanism of action
Efficacy
Efficacy in psoriatic arthritis
Safety
Precautions
Monitoring
Vaccinations
Summary and recommendations

Chapter 8. Etanercept
Key points
Introduction
Efficacy
Safety
Precautions
Monitoring
Vaccinations
Tumor necrosis factor inhibitor therapy and cardiovascular risk reduction
Summary

Chapter 9. Infliximab
Key points
Introduction
Mechanism of action
Efficacy
Efficacy in psoriatic arthritis
Safety
Precautions
Monitoring
Vaccinations
Summary and recommendations

Chapter 10. Adalimumab
Key points
Introduction
Mechanism of action
Efficacy
Safety
Precautions
Monitoring
Vaccinations
Tumor necrosis factor inhibitor therapy and cardiovascular risk reduction
Summary

Chapter 11. Ustekinumab
Key points
Introduction
Mechanism of action
Pharmacokinetics
Efficacy
Factors effecting decreased efficacy
Efficacy in palmoplantar psoriasis
Efficacy in pediatric psoriasis
Efficacy in psoriatic arthritis
Safety
Monitoring
Vaccinations
Summary and recommendations

Chapter 12. Secukinumab
Key points
Introduction
Mechanism of action
Efficacy
ERASURE and FIXTURE
FEATURE and JUNCTURE
Safety
Precautions
Monitoring
Vaccinations
Summary and recommendations

Chapter 13. Ixekizumab
Key points
Introduction
Mechanism of action
Efficacy
Safety
Precautions
Monitoring
Vaccinations
Summary

Chapter 14. Biosimilars
Key points
Introduction
Small molecule generic drugs
Creation of the biosimilar and analytical assessments
Regulation
Extrapolation
Inflectra
Clinical trials
Additional considerations and summary

Chapter 15. Combination Therapies for Psoriasis
Key points
Introduction

Chapter 16. Investigational Therapies for Psoriasis
Key points
Introduction
Anti-IL-17 agents
Anti-IL-23 agents
Summary
Index