Challenges after treatment for Childhood Cancer-1판

Cover image
Title page
Table of Contents
Copyright
CME Accreditation Page
Contributors
Forthcoming Issues
Foreword
Preface
Surviving Survival—Challenge Accepted!: Perspectives on Survivorship in Pediatric Oncology
Key points
Introduction: between the kingdom of the sick and the kingdom of the well—cured from cancer but not well enough
Survivor’s voices—from Erice, Italy, to Dublin, Ireland, (...) PanCare, and CCI
#RaiseYourHands4Survivors
Same but different? Different, but still the same!
When Childhood Cancer Becomes a Family Affair, It Really Hits Home
Key points
When your father is a pediatric oncologist: a patient’s view
When a pediatric oncologist’s own son is a patient: a parent’s view
Late Effects in Childhood Cancer Survivors: Early Studies, Survivor Cohorts, and Significant Contributions to the Field of
Late Effects
Key points
Introduction
Childhood cancer survivor cohorts in Europe and North America
Discussion
Radiotherapy and Late Effects
Key points
Introduction
Radiotherapy use in pediatric oncology
Biological effects of radiotherapy
Pathogenesis of tumorigenesis and late radiotherapy injury
Radiation techniques to mitigate toxicity
Impact of age on radiation injury
Common organ systems effected
Summary
The Critical Role of Clinical Practice Guidelines and Indicators in High-Quality Survivorship After Childhood Cancer
Key points
Introduction
Evidence-based medicine
Evidence-based clinical practice guidelines
Childhood cancer survivorship care guidelines
Dissemination and implementation of childhood cancer survivorship care guidelines
Evaluation of the quality of care
Summary
Childhood Cancer Survivorship: Daily Challenges
Key points
Background
Methods
Results
Discussion
Psychological Outcomes, Health-Related Quality of Life, and Neurocognitive Functioning in Survivors of Childhood Cancer and
Their Parents
Key points
Introduction
Psychological health and health-related quality of life
Neurocognitive functioning
Summary
Subsequent Primary Neoplasms: Risks, Risk Factors, Surveillance, and Future Research
Key points
Risks of subsequent primary neoplasms after childhood, adolescent, and young adult cancer
Subsequent primary neoplasm risk related to radiotherapy
Subsequent primary neoplasm risk related to chemotherapy
Risk of subsequent primary neoplasm and genomics
Role of surveillance, screening, and clinical follow-up guidelines
Priorities for future research
Cardiovascular and Pulmonary Challenges After Treatment of Childhood Cancer
Key points
Introduction
Cardiovascular disease
Pulmonary disease
Summary
Endocrine Health in Childhood Cancer Survivors
Key points
Introduction
Hypothalamic-pituitary dysfunction
Thyroid disorders
Metabolic syndrome
Bone toxicity in childhood cancer survivors
Summary
Reproductive Complications in Childhood Cancer Survivors
Key points
Introduction
Female gonadal toxicity, fertility, and reproductive complications
Male gonadal toxicity, fertility, and reproductive complications
Central hypogonadism (female and male)
Psychological consequences
Summary
Renal and Hepatic Health After Childhood Cancer
Key points
Introduction
Renal late effects
Hepatic late effects
Summary
Hearing and Other Neurologic Problems
Key points
Introduction
Ototoxicity
Other neurologic toxicities
Summary
The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress
Key points
Introduction
Large cohort collaboration: pooling of data to answer the unanswered questions
Defining genetic contributions to late effects risk
Identifying late effects of novel therapies
Identifying frailty and accelerated aging
Intervention and precision prevention of late effects
The future of health services research for childhood cancer survivors
Dissemination and implementation science to improve survivorship care
The future of evidence-based guideline development
Summary