Advances in Barrett’s Esophagus-1판

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma: Implications for Screening and
Surveillance
Key points
History
Epidemiology
Nature of the problem
Current evidence
Controversies
Future directions

Summary
Clinics care points
Endoscopic Screening for Barrett’s Esophagus and Esophageal Adenocarcinoma: Rationale, Candidates, and
Challenges

Key points
The rationale for Barrett’s esophagus screening
Risk factors for Barrett’s esophagus and esophageal adenocarcinoma
Selecting candidates for Barrett’s esophagus screening
Guidelines from national societies
Challenges with Barrett’s esophagus screening

Summary
Clinics care points
Progress in Screening for Barrett’s Esophagus: Beyond Standard Upper Endoscopy

Key points
Introduction
Rationale for screening
Identifying the at-risk population
Endoscopic screening using prediction models
Transnasal endoscopy
Cytosponge and immunohistochemistry for trefoil factor 3
ESOCHECK™ (LucidDx) balloon capsule and methylated DNA markers
Methylation biomarkers applied to other nonendoscopic cell sampling devices
Optical coherence tomography and tethered capsule endomicroscopy
Volatile organic compounds
Blood-based biomarkers

Summary
Clinics care points
Best Practices in Surveillance for Barrett's Esophagus

Key points
Introduction
Rationale for surveillance
Surveillance technique
Pitfalls in Surveillance
Future Prospects

Summary
Cost-Effectiveness of Screening, Surveillance, and Endoscopic Eradication Therapies for Managing the Burden
of Esophageal Adenocarcinoma
Key points
Introduction
Methods
Endoscopic eradication therapies for Barrett’s esophagus or early adenocarcinoma
Screening for Barrett’s esophagus and esophageal adenocarcinoma
Chemoprevention
Surveillance of nondysplastic Barrett’s esophagus
Discussion

Summary
Clinics care points
Advanced Imaging and Sampling in Barrett’s Esophagus: Artificial Intelligence to the Rescue?
Key points
Introduction
Artificial intelligence
Endoscopic imaging: white light endoscopy and optical chromoscopy
Volumetric laser endomicroscopy
Sampling techniques
Discussion
Clinics care points
Advances in Biomarkers for Risk Stratification in Barrett’s Esophagus

Key points
Dysplasia as a biomarker for risk stratification
Alternative biomarkers for risk stratification in Barrett’s esophagus
Biomarkers from the laboratory to clinical practice: ready or not here they come

Summary
Clinics care point
Current Status of Chemoprevention in Barrett’s Esophagus
Key points
Introduction
Proton pump inhibitor therapy
Nonsteroidal anti-inflammatory drugs
Hormone replacement therapy
Statins
Metformin

Summary
Clinics care points
Optimizing Outcomes with Radiofrequency Ablation of Barrett's Esophagus: Candidates, Efficacy and
Durability
Key points
Introduction
Candidates
Efficacy
Durability

Summary
Clinics care points
Updates in Cryotherapy for Barrett’s Esophagus
Key points
Introduction
Background and principles of cryotherapy
Cryotherapy devices for esophageal use
Cryotherapy for eradication of Barrett’s esophagus and related dysplasia
Discussion
Role of Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in the Management of Barrett’s
Related Neoplasia
Key points
Introduction
Indications for endoscopic resection
Endoscopic work-up
Performing endoscopic resection
Histopathological evaluation endoscopic resection specimens
Efficacy of endoscopic resection in management of Barrett’s-related neoplasia

Summary
Clinics care points
Supplementary data
A Practical Approach to Refractory and Recurrent Barrett's Esophagus
Key points
Introduction
Definition of Barrett’s eradication, refractory Barrett’s esophagus, and recurrence
Factors associated with refractory Barrett’s esophagus
Physiologic solutions to refractory Barrett’s esophagus
Salvage endoscopic eradication therapy
Risk of Barrett’s recurrence following endoscopic eradication therapy
Risk factors for Barrett’s Esophagus recurrence
Assessment for Barrett’s Esophagus recurrence
Approach to treatment and prevention of Recurrent Barrett’s Esophagus

Summary
Clinics care points
Surgical Management of Barrett’s-Related Neoplasia
Key points
Introduction
Limitations of endoscopic therapies for Barrett’s neoplasia
Considerations in the surgical management of Barrett’s-related neoplasia

Summary
Measuring Quality in Barrett’s Esophagus: Time to Embrace Quality Indicators

Key points
Introduction
Pre-procedure
Intra-procedure
Post-procedure
Discussion