Pathophysiology of Heart Disease-7판
- 저 자 : Lilly
- 역 자 :
- 출판사 : LWW
- ISBN(13) : 9781975120597
- 발행일 : 2020-07-28 / 7판 / 480 페이지
- 상품코드 : 27890
- 적립금: 1,440원
- 정가: $59.99
An Introduction to Cardiovascular Medicine
Chapter 1: Normal Cardiac Structure and Function
Cardiac Anatomy and Histology
Pericardium
Surface Anatomy of the Heart
Internal Structure of the Heart
Impulse-Conducting System
Cardiac Innervation
Cardiac Vessels
Histology of Ventricular Myocardial Cells
Basic Electrophysiology
Ion Movement and Channels
Resting Potential
Action Potential
Refractory Periods
Impulse Conduction
Normal Sequence of Cardiac Depolarization
Excitation-Contraction Coupling
Contractile Proteins in the Myocyte
Calcium-Induced Calcium Release and the Contractile Cycle
Introduction to Cardiac Signaling Systems
β-Adrenergic and Cholinergic Signaling
Review Questions
Chapter 2: The Cardiac Cycle: Mechanisms of Heart Sounds and Murmurs
Cardiac Cycle
Heart Sounds
First Heart Sound (S1)
Second Heart Sound (S2)
Extra Systolic Heart Sounds
Extra Diastolic Heart Sounds
Murmurs
Systolic Murmurs
Diastolic Murmurs
Continuous Murmurs
Review Questions
Chapter 3: Cardiac Imaging and Hemodynamic Assessment
Cardiac Radiography
Cardiac Silhouette
Pulmonary Manifestations of Heart Disease
Echocardiography
Ventricular Assessment
Valvular Lesions
Coronary Artery Disease
Cardiomyopathy
Pericardial Disease
Cardiac Catheterization
Measurement of Pressure
Measurement of Blood Flow
Calculation of Vascular Resistance
Contrast Angiography
Nuclear Imaging
Assessment of Myocardial Perfusion
Radionuclide Ventriculography
Assessment of Myocardial Metabolism
Computed Tomography
Magnetic Resonance Imaging
Integration
Review Questions
Chapter 4: The Electrocardiogram
Electrical Measurement— Single-Cell Model
Electrocardiographic Lead Reference System
Sequence of Normal Cardiac Activation
Interpretation of the Electrocardiogram
Calibration
Heart Rhythm
Heart Rate
Intervals (PR, QRS, QT)
Mean QRS Axis
Abnormalities of the P Wave
Abnormalities of the QRS Complex
ST-Segment and T-Wave Abnormalities
Review Questions
Chapter 5: Atherosclerosis
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Vascular Biology of Atherosclerosis
Normal Arterial Wall
Atherosclerotic Arterial Wall
Complications of Atherosclerosis
Atherosclerosis Risk Factors
Genetics
Inflammation
Traditional Risk Factors
Biomarkers of Cardiovascular Risk
Outlook
Review Questions
Chapter 6: Ischemic Heart Disease
Determinants of Myocardial Oxygen Supply and Demand
Myocardial Oxygen Supply
Myocardial Oxygen Demand
Pathophysiology of Ischemia
Fixed Vessel Narrowing
Endothelial Cell Dysfunction
Other Causes of Myocardial Ischemia
Consequences of Ischemia
Ischemic Syndromes
Clinical Features of Chronic Stable Angina
History
Physical Examination
Diagnostic Studies
Natural History
Treatment
Medical Treatment of an Acute Episode of Stable Angina
Medical Treatment to Prevent Recurrent Ischemic Episodes
Medical Treatment to Prevent Acute Cardiac Events
Revascularization
Medical vs Revascularization Therapy
Review Questions
Chapter 7: Acute Coronary Syndromes
Pathogenesis of Acute Coronary Syndromes
Normal Hemostasis
Endogenous Antithrombotic Mechanisms
Pathogenesis of Coronary Thrombosis
Non-Atherothrombotic Causes of Acute Myocardial Infarction
Pathology and Pathophysiology
Pathologic Evolution of Infarction
Functional Alterations
Clinical Features of Acute Coronary Syndromes
Clinical Presentation
Diagnosis of Acute Coronary Syndromes
Treatment of Acute Coronary Syndromes
Acute Treatment of Unstable Angina and Non–ST-Elevation Myocardial Infarction
Acute Treatment of ST-Segment Elevation Myocardial Infarction
Adjunctive Therapies
Complications
Recurrent Ischemia
Arrhythmias
Myocardial Dysfunction
Right Ventricular Infarction
Mechanical Complications
Pericarditis
Thromboembolism
Risk Stratification and Management Following Myocardial Infarction
Review Questions
Chapter 8: Valvular Heart Disease
Mitral Valve Disease
Mitral Stenosis
Mitral Regurgitation
Mitral Valve Prolapse
Aortic Valve Disease
Aortic Stenosis
Aortic Regurgitation
Tricuspid Valve Disease
Tricuspid Stenosis
Tricuspid Regurgitation
Pulmonic Valve Disease
Pulmonic Stenosis
Pulmonic Regurgitation
Surgical Prosthetic Valves
Infective Endocarditis
Pathogenesis
Clinical Manifestations
Treatment
Prevention
Review Questions
Chapter 9: Heart Failure
Physiology
Determinants of Contractile Function in the Intact Heart
Pressure-Volume Loops
Pathophysiology
Heart Failure With Reduced EF (HFrEF)
Heart Failure With Preserved EF (HFpEF)
Right-Sided Heart Failure
Compensatory Mechanisms
Frank-Starling Mechanism
Neurohormonal Alterations
Ventricular Hypertrophy and Remodeling
Myocyte Loss and Cellular Dysfunction
Precipitating Factors
Clinical Manifestations
Symptoms
Physical Signs
Diagnostic Studies
Prognosis
Treatment of Heart Failure With Reduced Ejection Fraction
Diuretics
Vasodilators
Positive Inotropic Drugs
β-Blockers
Aldosterone Antagonist Therapy
Additional Therapies
Treatment of Heart Failure With Preserved Ejection Fraction
Acute Heart Failure
Acute Pulmonary Edema
Review Questions
Chapter 10: The Cardiomyopathies
Dilated Cardiomyopathy
Etiology
Pathology
Pathophysiology
Clinical Findings
Physical Examination
Diagnostic Studies
Treatment
Hypertrophic Cardiomyopathy
Etiology
Pathology
Pathophysiology
Clinical Findings
Physical Examination
Diagnostic Studies
Treatment
Prognosis
Restrictive Cardiomyopathy
Pathophysiology
Clinical Findings
Physical Examination
Diagnostic Studies
Treatment
Other Forms of Cardiomyopathy
Left Ventricular Noncompaction
Arrhythmogenic Right Ventricular Cardiomyopathy
Review Questions
Chapter 11: Mechanisms of Cardiac Arrhythmias
Normal Impulse Formation
Ionic Basis of Automaticity
Native and Latent Pacemakers
Overdrive Suppression
Electrotonic Interactions
Altered Impulse Formation
Alterations in Sinus Node Automaticity
Escape Rhythms
Enhanced Automaticity of Latent Pacemakers
Abnormal Automaticity
Triggered Activity
Altered Impulse Conduction
Conduction Block
Unidirectional Block and Reentry
Physiologic Basis of Antiarrhythmic Therapy
Bradyarrhythmias
Tachyarrhythmias
Review Questions
Chapter 12: Clinical Aspects of Cardiac Arrhythmias
Bradyarrhythmias
Sinoatrial Node
Escape Rhythms
Atrioventricular Conduction System
Tachyarrhythmias
Supraventricular Arrhythmias
Ventricular Arrhythmias
Review Questions
Chapter 13: Hypertension
What is Hypertension?
How is Blood Pressure Regulated?
Hemodynamic Factors
Blood Pressure Reflexes
Essential Hypertension
Genetics and Epidemiology
Experimental Findings
Natural History
Secondary Hypertension
Patient Evaluation
Exogenous Causes
Renal Causes
Mechanical Causes
Endocrine Causes
Consequences of Hypertension
Clinical Signs and Symptoms
Organ Damage Caused by Hypertension
Hypertensive Crisis
Treatment of Hypertension
Nonpharmacologic Treatment
Pharmacologic Treatment
Review Questions
Chapter 14: Diseases of the Pericardium
Anatomy and Function
Acute Pericarditis
Etiology
Pathology
Clinical Features
Diagnostic Studies
Treatment
Pericardial Effusion
Etiology
Pathophysiology
Clinical Features
Diagnostic Studies
Treatment
Cardiac Tamponade
Etiology
Pathophysiology
Clinical Features
Diagnostic Studies
Treatment
Constrictive Pericarditis
Etiology and Pathogenesis
Pathology
Pathophysiology
Clinical Features
Diagnostic Studies
Treatment
Review Questions
Chapter 15: Diseases of the Peripheral Vasculature
Diseases of the Aorta
Aortic Aneurysms
Aortic Dissection
Peripheral Artery Diseases
Peripheral Atherosclerotic Vascular Disease
Acute Arterial Occlusion
Vasculitic Syndromes
Vasospasm: Raynaud Phenomenon
Venous Disease
Varicose Veins
Chronic Venous Insufficiency
Venous Thromboembolism
Review Questions
Chapter 16: Congenital Heart Disease
Normal Development of the Cardiovascular System
Development of the Heart Tube
Formation of the Heart Loop
Septation
Development of the Cardiac Valves
Fetal and Transitional Circulations
Fetal Circulation
Transitional Circulation
Common Congenital Heart Lesions
Acyanotic Lesions
Cyanotic Lesions
Eisenmenger Syndrome
Review Questions
Chapter 17: Cardiovascular Drugs
Inotropic Drugs and Vasopressors
Cardiac Glycosides (Digitalis)
Sympathomimetic Amines
Phosphodiesterase-3 Inhibitors
Vasopressin
Vasodilator Drugs
Angiotensin-Converting Enzyme Inhibitors
Angiotensin II Type 1 Receptor Antagonists
Angiotensin Receptor-Neprilysin Inhibitor
Direct-Acting Vasodilators
Calcium Channel Blockers
Organic Nitrates
Natriuretic Peptides
Phosphodiesterase-5 Inhibitors
Endothelin Receptor Antagonists
Antiadrenergic Drugs
Central Adrenergic Inhibitors (CNS α2-Agonists)
Sympathetic Nerve-Ending Antagonists
Peripheral α-Adrenergic Receptor Antagonists
β-Adrenergic Receptor Antagonists
Antiarrhythmic Drugs
Class IA Antiarrhythmics
Class ib Antiarrhythmics
Class ic Antiarrhythmics
Class ii Antiarrhythmics
Class iii Antiarrhythmics
Class iv Antiarrhythmics
Adenosine
Diuretics
Loop Diuretics
Thiazide Diuretics
Potassium-Sparing Diuretics
Antithrombotic Drugs
Platelet Inhibitors
Anticoagulant Drugs: Parenteral Agents
Anticoagulant Drugs: Oral Agents
Lipid-Regulating Drugs
HMG-CoA Reductase Inhibitors
Cholesterol Absorption Inhibitor
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors
n-3 Fatty Acids
Bile Acid–Binding Agents
Niacin
Fibrates
Review Questions
Index