Snyder And Champness Molecular Genetics Of Bacteria-5판

Introduction
The Biological Universe
What Is Genetics?
Bacterial Genetics
Phage Genetics
A Brief History of Bacterial Molecular Genetics
What Is Ahead

1 The Bacterial Chromosome: DNA Structure, Replication, and Segregation
DNA Structure
The Mechanism of DNA Replication
Replication Errors
Impediments to DNA Replication
Replication of the Bacterial Chromosome and Cell Division
The Bacterial Nucleoid
The Bacterial Genome

2 Bacterial Gene Expression: Transcription, Translation, Protein Folding, and Localization
Overview
The Structure and Function of RNA
Transcription
RNA Degradation
The Structure and Function of Proteins
Translation
Protein Folding and Degradation
Protein Localization
Protein Secretion and Export
Regulation of Gene Expression
What You Need To Know

3 Bacterial Genetic Analysis: Fundamentals and Current Approaches
Definitions
Inheritance in Bacteria
Mutation Rates
Types of Mutations
Reversion versus Suppression
Genetic Analysis in Bacteria
Perspective

4 Plasmids
What Is a Plasmid?
Properties of Plasmids

5 Conjugation
Overview
Mechanism of DNA Transfer during Conjugation in Proteobacteria
Chromosome Transfer by Plasmids
Diversity in Transfer Systems
Integrating Conjugative Elements

6 Transformation
Natural Transformation
Artificially Induced Competence

7 Bacteriophages and Transduction
Lytic Development
Lysogenic Development
Genetic Analysis of Phages
Phage-Mediated Genetic Transfer
Host Defenses Against Phage Infection
Phages as Tools

8 Transposition, Site-Specific Recombination, and Families of Recombinases
Transposition
Mechanisms of Transposition
General Properties of Transposons
Transposon Mutagenesis
Site-Specific Recombination
Y and S Recombinases
Group II Mobile Introns: Elements that Move Using an RNA Intermediate
Importance of Transposition and Site-Specific Recombination in Bacterial Adaptation

9 Molecular Mechanisms of Homologous Recombination
Homologous Recombination and DNA Replication in Bacteria
The Molecular Basis for Recombination in E. coli
Recombination between Different DNAs in Bacteria
Recombineering: Gene Replacements in E. coli with Phage λ Recombination Functions

10 DNA Repair and Mutagenesis
Evidence for DNA Repair
Specific Repair Pathways
General Repair Mechanisms
DNA Damage Tolerance Mechanisms
Summary of Repair Pathways in E. coli
Bacteriophage Repair Pathways

11 Regulation of Gene Expression: Genes and Operons
Transcriptional Regulation in Bacteria
Negative Regulation of Transcription Initiation
Positive Regulation of Transcription Initiation
Regulation by Transcription Attenuation
Regulation of mRNA Degradation
Regulation of Translation
Posttranslational Regulation
Why Are There So Many Mechanisms of Gene Regulation?

12 Global Regulation: Regulons and Stimulons
Carbon Catabolite Regulation
Regulation of Nitrogen Assimilation
Regulation of Ribosome Components and tRNA Synthesis
Ribosomal Protein Gene Regulation
Stress Responses in Bacteria
Iron Regulation in E. coli
Regulation of Virulence Genes in Pathogenic Bacteria
Developmental Regulation: Sporulation in B. subtilis

13 Genomes and Genomic Analysis
The Bacterial Genome
DNA Sequencing
Barriers to Horizontal Transfer: Genome Gatekeepers and the Molecular Biologist’s Toolkit
Glossary
End Papers


Index
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