Autoimmune Liver Disease

Description

A practical guide to autoimmune liver diseases through pathogenesis, diagnosis, and management
In Autoimmune Liver Disease Management and Clinical Practice, practitioners will learn about the current state of
autoimmune liver disease and how to focus on their diagnosis and treatment. The four-part book begins with a thorough
investigation of current immunological thinking as it relates to the autoimmunity of the liver. It also covers the
four major hepatic autoimmune liver diseases in both adults and children, their management and the role of liver
transplantation, and learned approaches to patient management and empowerment.
Expert authors in the field have come together to provide a thorough examination of autoimmune liver disease to
help support clinicians assisting patients.

The text provides an in-depth look at topics including:

The four major hepatic autoimmune liver diseases, their diagnosis, and potential disease management

The use (and misuse) of autoantibodies in diagnosis and treatment

The role and timing of liver transplantation and the impact of recurrent autoimmune liver disease as well as
de novo autoimmune hepatitis

Optimal approaches to managing patients and keeping care personalised

Section I Scientific Basis of Clinical Autoimmune Liver Diseases 3
1 Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree 5
2 Concepts of Autoimmunity Relevant to Autoimmune Liver Diseases 21
3 Genetics and Risk of Autoimmune Liver Diseases 47
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Section II Autoimmune Liver Diseases and Their Clinical Correlation 103
6 Autoimmune Hepatitis 105
7 Primary Biliary Cholangitis 123
8 Primary Sclerosing Cholangitis 143
9 IgG4‐Related Liver and Biliary Disease 163

Section III Specific Clinical Challenges 181
10 Managing Acute and Chronic Seronegative Liver Disease 183
11 Managing Pregnant Women with Autoimmune Liver Disease 201
12 Bone Health in Patients with Autoimmune Liver Diseases 219

Section IV Transplantation and Its Role in Autoimmune Liver Disease 233
13 Recurrent Autoimmune Liver Disease and Its Impact on Clinical Practice 235
14 Recurrent Autoimmune Liver Disease and its Scientific Significance 247

Section V Controversies in Autoimmune Liver Diseases 263
15 Making Sense of Overlap and Crossover Syndromes 265
16 The Role of Extrahepatic Autoimmunity in Autoimmune Liver Disease 277
17 Symptoms, Chronic Disease, and Patient Management 289

Index 301