The Liver: Biology and Pathobiology-6판

Description

Bridging the gap between basic scientific advances and the understanding of liver disease ― the extensively
revised new edition of the premier text in the field.
The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology,
relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease
pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the
pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more.

Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and
their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters ― including substantial
original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology ―
provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology.

Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the
molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and
therapies. Edited by globally-recognized experts in the field, this authoritative volume:

Relates molecular physiology to understanding disease pathology and treatment

Links the science and pathology of the liver to practical clinical applications

Features 16 new “Horizons” chapters that explore new and emerging science and technology

Includes plentiful full-color illustrations and figures

Part One: Introduction 1

Part Two: The Cells 23
Section A: Cell Biology of the Liver 25
Section B: The Hepatocyte 207
Section C: Transporters, Bile Acids, and Cholestasis 269
Section D: Non?Hepatocyte Cells 391

Part Three: Functions of The Liver 455
Section A: Metabolic Functions 457
Section B: Liver Growth and Regeneration 521

Part Four: Pathobiology of Liver Disease 615

Part Five: Liver Cancer 747

Part Six: Hepatitis 793

Part Seven: Horizons 953

Index 1081