Description
Comprehensive, concise, and accessible, Wyllie’s Treatment of Epilepsy: Principles and Practice has provided a
detailed and cohesive overview of seizure disorders and treatment options through six well-regarded editions.
The 7th Edition remains the definitive reference in the field with extensive updates from Dr. Elaine Wyllie and her
team of world-renowned editors and authors. Ideal for both clinical reference and exam preparation, this single-volume
work on contemporary epileptology is an indispensable resource for neurologists, epilepsy specialists and epilepsy
neurosurgeons, neurology and neurosurgery residents and fellows, and neuropsychologists
options.
medications; principles of electroencephalography; psychosocial impact, quality of life, and comorbidities; economics
of epilepsy; and more.
exam and clinical practice.
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PART I: Epidemiology, Genetics, and Mechanisms of Epileptogenesis
CHAPTER 1 Epidemiologic Aspects of Epilepsy
CHAPTER 2 The Natural History and Prognosis of Epilepsy
CHAPTER 3 Experimental Models of Seizures and Mechanisms of Status Epilepticus and Epileptogenesis
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CHAPTER 4 Genetic Aspects of the Epilepsies
CHAPTER 5 Pictorial Atlas of Epilepsy Substrates
PART II: Basic Principles of Electroencephalography
CHAPTER 6 Neurophysiologic Basis of the Electroencephalogram
CHAPTER 7 Localization and Field Determination in Electroencephalography
CHAPTER 8 Electroencephalographic Atlas of Epileptiform Abnormalities
CHAPTER 9 Quality Standards and Logistics of Establishing an Epilepsy Monitoring Unit
PART III: Epileptic Seizures and Syndromes
SECTION A: Electroclinical Syndromes
CHAPTER 10 The Revised Definition and Classification of Seizures and Epilepsies
CHAPTER 11 Seizure Types and Semiology
CHAPTER 12 Epileptic Auras
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CHAPTER 13 Focal Epileptogenic Networks
CHAPTER 14 Electroclinical Syndromes of Infancy
CHAPTER 15 Electroclinical Syndromes in Childhood and Adolescence
CHAPTER 16 Continuous Spike-and-Wave During Sleep, Including Landau–Kleffner Syndrome
CHAPTER 17 Epilepsy with Reflex Seizures
SECTION B: Specific Etiologies
CHAPTER 18 Hippocampal Sclerosis and Dual Pathology
CHAPTER 19 Malformations of Cortical Development and Epilepsy
CHAPTER 20 New Neuropathologic Concepts in Focal Cortical Dysplasias
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CHAPTER 21 Brain Tumors and Epilepsy
CHAPTER 22 Posttraumatic Epilepsy
CHAPTER 23 Epilepsy in the Setting of Cerebrovascular Disease
CHAPTER 24 Epilepsy in the Setting of Neurocutaneous Syndromes
CHAPTER 25 Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders
CHAPTER 26 Progressive Myoclonic Epilepsies
CHAPTER 27 Central Nervous System Infections and Epilepsy
CHAPTER 28 Autoimmune Epilepsy and Encephalitis
CHAPTER 29 Rasmussen Encephalitis
SECTION C: Diagnosis And Treatment Of Seizures In Special Clinical Settings
CHAPTER 30 Febrile Seizures and Genetic Epilepsy with Febrile Seizures Plus (GEFS+)
CHAPTER 31 Approach to the Patient with a First Seizure
CHAPTER 32 Neonatal Seizures and EEG
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CHAPTER 33 Epilepsy in the Elderly
CHAPTER 34 Seizures Associated with Nonneurologic Medical Conditions
CHAPTER 35 Sleep and Epilepsy
CHAPTER 36 Status Epilepticus
CHAPTER 37 Electroencephalography and Seizures in the Intensive Care Setting
SECTION D: Differential Diagnosis Of Epilepsy
CHAPTER 38 Psychogenic Nonepileptic Seizures
CHAPTER 39 Other Nonepileptic Paroxysmal Disorders
PART IV: Antiseizure Medications
SECTION A: General Principles Of Antiseizure Medication Therapy
CHAPTER 40 Antiseizure Medication Development and Experimental Models
CHAPTER 41 Mechanisms of Action of Antiseizure Medication
CHAPTER 42 Pharmacokinetics and Drug Interactions
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CHAPTER 43 Initiation and Discontinuation of Antiseizure Medications
CHAPTER 44 Treatment of Acute and Repetitive Seizures
CHAPTER 45 Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy
CHAPTER 46 Treatment of Epilepsy During Pregnancy
CHAPTER 47 Individual Approach to Laboratory Monitoring of Antiseizure Medication
SECTION B: Specific Antiepileptic Medications And Treatments
CHAPTER 48 Benzodiazepines
CHAPTER 49 Carbamazepine, Oxcarbazepine, and Eslicarbazepine
CHAPTER 50 Ethosuximide
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CHAPTER 51 Felbamate
CHAPTER 52 Gabapentin and Pregabalin
CHAPTER 53 Lacosamide
CHAPTER 54 Lamotrigine
CHAPTER 55 Levetiracetam and Brivaracetam
CHAPTER 56 Perampanel
CHAPTER 57 Phenobarbital and Primidone
CHAPTER 58 Phenytoin and Fosphenytoin
CHAPTER 59 Rufinamide
CHAPTER 60 Topiramate
CHAPTER 61 Valproate
CHAPTER 62 Vigabatrin
CHAPTER 63 Zonisamide
CHAPTER 64 Adrenocorticotropin and Steroids
CHAPTER 65 Cannabidiol
CHAPTER 66 Antiseizure Medications in Clinical Development
CHAPTER 67 Less Commonly Used Antiseizure Medications
CHAPTER 68 Dietary Therapies for Epilepsy
PART V: Epilepsy Surgery
SECTION A: Identifying Surgical Candidates And Defining The Epileptogenic Network
CHAPTER 69 Issues of Medical Intractability for Surgical Candidacy
CHAPTER 70 Magnetic Resonance Imaging in the Evaluation for Epilepsy Surgery
CHAPTER 71 Video–EEG Monitoring in the Presurgical Evaluation
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CHAPTER 72 Nuclear Imaging (PET, SPECT)
CHAPTER 73 Magnetoencephalography
CHAPTER 74 MRI Postprocessing Techniques and Clinical Applications
CHAPTER 75 MRI Connectivity Analyses: Imaging Networks in Epilepsy
CHAPTER 76 Diffusion Tensor Imaging (DTI) and EEG-Correlated fMRI
CHAPTER 77 Mapping Epileptic Networks with Intracranial Electrodes
SECTION B: Mapping Eloquent Cortex
CHAPTER 78 Functional Mapping with Neurophysiologic Techniques
CHAPTER 79 Language and Memory Mapping
SECTION C: Epilepsy Surgery In Specific Clinical Settings
CHAPTER 80 Surgery for Medically Refractory Temporal Lobe Epilepsy
CHAPTER 81 Surgery for Focal Cortical Dysplasias (FCDs)
CHAPTER 82 Hemispherectomy: Indications, Procedures, and Outcome
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CHAPTER 83 Surgical Approach in Multilesional or Multilobar Epilepsies
CHAPTER 84 Surgical Approach in Nonlesional Cases
CHAPTER 85 Hypothalamic Hamartoma
CHAPTER 86 Corpus Callosotomy and Multiple Subpial Transection
CHAPTER 87 Epilepsy Surgery: Special Considerations in Children
CHAPTER 88 Ablative Treatments for Epilepsy
CHAPTER 89 Outcome and Complications of Epilepsy Surgery
CHAPTER 90 Vagus Nerve Stimulation Therapy
CHAPTER 91 Responsive Neurostimulation Therapy: RNS System
CHAPTER 92 Deep Brain Stimulation Epilepsy
PART VI: PSYCHOSOCIAL IMPACT, QUALITY OF LIFE, AND COMORBIDITIES, AND ECONOMICS OF EPILEPSY
CHAPTER 93 Cognitive Effects of Epilepsy and Its Treatments
CHAPTER 94 Psychiatric Comorbidity of Epilepsy
CHAPTER 95 Sudden Unexpected Death in Epilepsy (SUDEP)
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CHAPTER 96 Driving and Social Issues in Epilepsy
CHAPTER 97 Ambulatory Seizure Monitoring and Acute Seizure Detection
CHAPTER 98 Quality of Life with Epilepsy
Index