Diagnostic Pathology: Molecular Oncology-2판
- 저 자 : Vasef
- 역 자 :
- 출판사 : Elsevier
- ISBN(13) : 9780323611442
- 발행일 : 2019-08-05 / 2판 / 1016 페이지
- 상품코드 : 27239
- 적립금: 8,190원
- 정가: $347.99
Description
Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer,
this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels
of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills.
This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated
with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical,
clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant
and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies.
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neoplasms, and new targeted therapies geared toward these molecular alterations
of many neoplasms such as breast and lung carcinomas and lymphoma
based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS)
sequencing studies of new mutations and the resulting newly developed molecular targets
SECTION 1: INTRODUCTION
Chapter 1: Structure of Chromosomes and Nucleic Acids
Chapter 2: DNA Replication, Transcription, and Translation
Chapter 3: Gene Mutations
SECTION 2: COMMON TECHNIQUES FOR ANALYSIS OF ALTERATIONS IN CHROMOSOMES AND DNA
Chapter 4: Cytogenetics and FISH
Chapter 5: Chromosomal Microarray
Chapter 6: Amplification Methods
Chapter 7: DNA High-Resolution Melting Curve Analysis
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Chapter 8: Sequencing Technologies
Chapter 9: High-Throughput Methods in Molecular Pathology
Chapter 10: DNA Methylation Analysis
SECTION 3: MOLECULAR GENETIC TESTS IN HEMATOPOIETIC TUMORS
Chapter 11: BCR-ABL1 Fusion Gene
Chapter 12: PML-RARA Fusion Gene
Chapter 13: Reverse Transcription PCR for Other Myeloid Leukemia Transcripts
Chapter 14: FLT3, NPM1, and CEBPA Mutations
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Chapter 15: JAK2 Mutations and Rearrangements
Chapter 16: MPL Mutations
Chapter 17: Calreticulin (CALR) Mutations
Chapter 18: CSF3R Mutations
Chapter 19: SETBP1 Mutations
Chapter 20: KIT Mutations
Chapter 21: IDH1 and IDH2 Mutations
Chapter 22: Other Mutations and Gene Panel Testing in Myeloid Neoplasms
Chapter 23: Immunoglobulin Heavy (IGH) Chain Gene Rearrangements
Chapter 24: T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements
Chapter 25: T-Cell Receptor Beta (TRB) Chain Gene Rearrangements
Chapter 26: Southern Blot Analysis of Antigen Receptor Genes
Chapter 27: EBV-Associated Human Neoplasms
Chapter 28: MYD88 Mutation
Chapter 29: NOTCH1 Mutation
Chapter 30: EZH2 Mutation
SECTION 4: MOLECULAR GENETIC TESTS IN SOLID TUMORS, BONE AND SOFT TISSUE TUMORS, AND CNS
TUMORS
Chapter 31: ALK Gene Rearrangements and Mutations
Chapter 32: ROS1 Rearrangements
Chapter 33: RET Rearrangements
Chapter 34: FISH for MET Amplifications
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Chapter 35: FISH for ERBB2 (HER2) Gene Amplifications
Chapter 36: KRAS Mutations
Chapter 37: BRAF Mutations
Chapter 38: EGFR Mutations
Chapter 39: Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next-Generat
Chapter 40: Targeted Hotspot Gene Panel Table
Chapter 41: MGMT Promoter Gene Methylation Assay
SECTION 5: MOLECULAR PATHOLOGY OF MYELOID NEOPLASMS
Chapter 42: Molecular Work-Up of Myeloid Neoplasms
Chapter 43: Chronic Myeloid Leukemia, BCR-ABL1 Positive
Chapter 44: Chronic Neutrophilic Leukemia
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Chapter 45: Polycythemia Vera
Chapter 46: Primary Myelofibrosis
Chapter 47: Essential Thrombocythemia
Chapter 48: Chronic Eosinophilic Leukemia, NOS
Chapter 49: Myeloproliferative Neoplasms, Unclassifiable
Chapter 50: Mastocytosis
Chapter 51: Myeloid/Lymphoid Neoplasms With Eosinophilia and Gene Rearrangement
Chapter 52: Overview and Classification of Myelodysplastic Syndrome
Chapter 53: Myelodysplastic Syndromes With Single-Lineage Dysplasia
Chapter 54: Myelodysplastic Syndrome With Ring Sideroblasts
Chapter 55: Myelodysplastic Syndrome With Multilineage Dysplasia
Chapter 56: Myelodysplastic Syndrome With Isolated del(5q)
Chapter 57: Myelodysplastic Syndrome, Unclassifiable
Chapter 58: Childhood Myelodysplastic Syndrome and Refractory Cytopenia of Childhood
Chapter 59: Overview of Myelodysplastic/Myeloproliferative Neoplasms
Chapter 60: Chronic Myelomonocytic Leukemia
Chapter 61: Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
Chapter 62: Juvenile Myelomonocytic Leukemia
Chapter 63: Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable
Chapter 64: Overview of Acute Myeloid Leukemia
Chapter 65: Acute Myeloid Leukemia With t(8;21); RUNX1-RUNX1T1
Chapter 66: Acute Myeloid Leukemia With inv(16) or t(16;16); CBFB-MYH11
Chapter 67: Acute Promyelocytic Leukemia With t(15;17); PML-RARA
Chapter 68: Acute Myeloid Leukemia With t(9;11); MLLT3-KMT2A
Chapter 69: Acute Myeloid Leukemia With t(6:9); DEK-NUP214
Chapter 70: Acute Myeloid Leukemia With inv(3) or t(3;3); GATA2, MECOM
Chapter 71: Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22); RBM15-MRTFA
Chapter 72: Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Chapter 73: Acute Myeloid Leukemia, NOS
Chapter 74: Therapy-Related Myeloid Neoplasms
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