Principles of Medicinal Chemistry-8판

With expert contributions from experienced educators, research scientists and clinicians, Foye's Principles of 
Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy 
faculty alike.  This 'gold standard' text explains the chemical basis of drug action, emphasizing the structure-
activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used 
drugs.

ㆍComprehensive coverage of the most cutting edge understanding of drug chemistry, organized and written for ready  
  comprehension 
ㆍExtensively referenced to allow learners to explore areas of interest in greater depth 
ㆍContemporary focus on drugs viewed by practitioners as the most clinically important in today’s health care 
  environment 
ㆍClinical Significance testimonials that provide a clinician’s view of the relevance of medicinal chemistry to 
  practice 
ㆍScience-practice interface made explicit through drug monographs that highlight therapeutic indications, adverse 
  reactions and drug-drug interactions 
ㆍEnd-of-Chapter exercises that allow learners to test their understanding and recall of key concepts

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Part I  Principles

CHAPTER 1  Introduction to Medicinal Chemistry
CHAPTER 2  Foundational Principles and Functional Group Impact on Activity
CHAPTER 3  Drug Metabolism
CHAPTER 4  Membrane Drug Transporters
CHAPTER 5  Principles of Biotechnology-Derived Drugs

Part II  Receptor Targets

CHAPTER 6  G Protein–Coupled Receptors
CHAPTER 7  Nuclear Receptors
CHAPTER 8  Ion Channel Receptors
CHAPTER 9  Enzyme/Catalytic Receptors

Part III  Pharmacodynamic Agents

Section 1 Drugs Impacting the Central Nervous System
CHAPTER 10  Drugs Used to Treat Neuromuscular Disorders
CHAPTER 11  Drugs Used to Treat Mental, Behavioral, and Cognitive Disorders
CHAPTER 12  Drugs Used to Induce/Support Sedation or Anesthesia
CHAPTER 13  Drugs Used to Treat Seizure Disorders

Section 2 Drugs Impacting Pain Perception
CHAPTER 14  Drugs Used to Treat Pain: Centrally Acting Agents
CHAPTER 15  Drugs Used to Treat Pain: Peripherally Acting Agents

Section 3 Drugs Impacting the Cardiovascular System
CHAPTER 16  Drugs Used to Treat Cardiac Disorders
CHAPTER 17  Drugs Used to Treat Hypertensive/Hypotensive Disorders
CHAPTER 18  Drugs Used to Treat Coagulation Disorders
CHAPTER 19  Drugs Used to Treat Dyslipidemic Disorders

Section 4 Drugs Impacting Hormonal Systems
CHAPTER 20  Drugs Used to Treat Diabetic Disorders
CHAPTER 21  Drugs Used to Treat Inflammatory and Corticosteroid Deficiency Disorders
CHAPTER 22  Drugs Used to Treat Thyroid Disorders
CHAPTER 23  Drugs Used to Treat Calcium-Dependent Disorders
CHAPTER 24  Drugs Used to Advance Men’s and Women’s Health

Section 5 Drugs Impacting Immune, Gastrointestinal and Genitourinary Systems
CHAPTER 25  Drugs Used to Treat Allergic Disorders
CHAPTER 26  Drugs Used to Treat Gastrointestinal and Genitourinary Disorders

Section 6 Drugs Impacting Ocular, Nasal and Pulmonary Systems
CHAPTER 27  Drugs Used to Treat Ocular and Nasal Congestion Disorders
CHAPTER 28  Drugs Used to Treat Pulmonary Disorders

Section 7 Drugs Impacting Infectious and Neoplastic Disease Processes
CHAPTER 29  Drugs Used to Treat Bacterial Infections
CHAPTER 30  Drugs Used to Treat Viral Infections
CHAPTER 31  Drugs Used to Treat Fungal Infections
CHAPTER 32  Drugs Used to Treat Parasitic Infections
CHAPTER 33  Drugs Used to Treat Neoplastic Diseases

Section 8 Therapeutic Biologics
CHAPTER 34  Biologics Used in the Treatment of Disease

Part IV  Disease State Management

CHAPTER 35  Coronary Artery Disease
CHAPTER 36  Rheumatoid Arthritis
CHAPTER 37  Nutrition and Obesity

Appendix A  cLogP and cLogDpH 7.4 Values of Selected Drugs
Appendix B  Predicted pKa Values of Commonly Prescribed Drugs
Appendix C  pH Values of Biological Fluids
Subject Index
Drug Index