Fetal Medicine-3판

Covering pertinent basic science and offering today's most authoritative guidance on clinical management, 
Fetal Medicine, 3rd Edition, is a must-have resource for obstetricians and other healthcare professionals involved in 
care of the fetus. An international team of expert contributors delivers the knowledge and background you need to 
effectively diagnose and treat fetal disorders - everything from prenatal screening and diagnostic tests to common and 
rare prenatal conditions, early pregnancy loss, ethical issues, and much more.

Focuses on fetal medicine throughout, bringing you today's most reliable information in both basic science and 
   clinical topics. 
Offers updated information from cover to cover, including new coverage of genetics, embryology, and clinical 
   management. 
Features new self-assessment questions, new video clips, and new images throughout - for a total of nearly 1,000 
   photographs and line drawings, as well as more than 150 quick-reference tables. 
Details fast-changing developments in fetal medicine, including advances in ultrasound imaging, cytogenetics, 
   molecular biology, and biochemistry. 
Helps you learn and retrieve complex information quickly thanks to succinct, highly structured text; key points at 
   the beginning of each chapter; and concise chapter summaries. 
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, 
   and references from the book on a variety of devices. 




Section 1: Early Fetal Development

1 Early Concepts and Terminology, 2 Patricia Collins 
2 Cellular Mechanisms and Embryonic Tissues, 6 Patricia Collins 
3 Staging Embryos in Development and theEmbryonic Body Plan, 23 Patricia Collins
4 Teratology, 30Sarah G. Obican and Anthony R. Scialli 
5 Early Pregnancy Failure, 38 Davor Jurkovic and Kuhan Rajah
 
Section 2: The Placenta

6 The Immunology of Implantation, 48 Ashley Moffett, Y.W. Loke and Andrew Sharkey 
7 Development of the Placenta and ItsCirculation, 55 Caroline E. Dunk, 
  Berthold Huppertz and John C. Kingdom 
8 Placental Function in MaternofetalExchange, 69 Colin Sibley and Mark Dilworth 
9 Placental Pathology and Implications for FetalMedicine, 78 
  Neil J. Sebire and John C. Kingdom 

Section 3: Fetal Physiology and Pathology

10 Development of the Heart and Cardiovascular
   System in Relation to Cardiac Abnormalities, 88Michael Ashworth 
11 Lung Growth and Maturation, 103 
   Richard Harding, Annie R.A. McDougall and Stuart B. Hooper 
12 Development of the Kidneys and Urinary Tract in
   Relation to Renal Anomalies, 114Paul J.D. Winyard 
13 The Perinatal Postmortem Examination, 121 
   J. Ciaran Hutchinson, Susan C. Shelmerdine and Neil J. Sebire
 
Section 4: Epidemiology

14 Epidemiologic and Research Methods in FetalMedicine, 132 
   Cande V. Ananth and Alan T. Tita 

Section 5: Ethics

15 Ethical Issues in Maternal-Fetal Medicine, 139 
   Wybo J. Dondorp and Guido M. de Wert 

Section 6: Prenatal Screening and Diagnosis

16 Principles of Screening, 149 
   Joshua I. Rosenbloom and George A. Macones 
17 Conveying Information About Screening andDiagnosis, 154
   Jenny Hewison, Louise D. Bryant and Jane Fisher 
18 Ultrasound and Biochemical Screening for Feta Aneuploidy, 161 
   Howard Cuckle and Ran Neiger 
19 Ultrasound Screening for Fetal Abnormalities in the First Trimester, 176 
   Caterina M. Bilardo and Frederick Ushakov 
20 Evidence for Routine Ultrasound Screening forFetal
   Abnormalities in the Second and ThirdTrimesters, Yalda Afshar, Rashmi Rao, 
   Anahit Martirosian andLawrence D. Platt
21 Noninvasive Screening for Cytogenetic Disorder
   (Fetal Aneuploidy Including Microdeletions), 202 
   Karen Wou and Ronald J. Wapner 
22 Noninvasive Prenatal Diagnosis for Single-GeneDisorders, 214 
   Melissa Hill and Lyn S. Chitty 

Contents
Contents vii

23 Invasive Diagnostic Procedures, 225 
   Anthony O. Odibo and Ganesh Acharya 
24 Prenatal Diagnosis of Chromosome Abnormalities, 233 
   Colleen G. Bilancia, Mythily Ganapathi and Brynn Levy 
25 Advances in Molecular Genetics Including Fetal Sequencing, 247
   Magdalena Walkiewicz and Ignatia B. Van den Veyver 
26 Expanded Carrier Screening, 254 Liran Hiersch and Yuval Yaron 
27 Prenatal Screening for Thalassemias, 263 Kwok Yin Leung, Patrick Au and Mary Tang 

Section 7: Diagnosis and Management of Fetal Malformations

28 Sonography of the Fetal Central Nervous System, 275
   Luc De Catte, Bart De Keersmaecker, Luc Joyeux and Michael Aertsen 
29 The Heart, 305 Christoph Wohlmuth and Helena M. Gardiner 
30 Fetal Lung Lesions, 324 James Cook, Angela Yulia, 
   Colin Wallis and Pranav P. Pandya
31 Congenital Diaphragmatic Hernia, 332
   Francesca Maria Russo, Liesbeth Lewi, Jute Richter andJan Deprest
32 Abdomen, 340 Jon Hyett
33 Kidney and Urinary Tract Disorders, 351 Roland Devlieger and An Hindryckx 
34 Diagnosis and Management of Fetal Skeletal Abnormalities,
   Ly S. Chitty, Louise C. Wilson and Frederick Ushakov 
35 Diagnosis and Management of Abnormalities ofthe Face,  
   Elisabeth de Jong-Pleij and Caterina M. Bilardo 
36 Fetal Hydrops, 427 
   Sylvie Langlois and R. Douglas Wilson 
37 Fetal Tumours, 443 
   Thomas R. Everett, Rosalind Pratt, Colin R. Butler, Richard J.
   Hewitt, Paolo De Coppi and Pranav P. Pandya
38 Open Fetal Surgery, 454 Luc Joyeux, Frank Van Calenbergh, Roland Devlieger,
   Luc De Catte and Jan Deprest 

Section 8: Diagnosis and Management of

Other Fetal Conditions

39 Fetal Growth and Growth Restriction, 469 
   Emily J. Su and Henry L. Galan 
40 Haemolytic Disease of the Fetus and Newborn, 484 
   Saul Snowise and Kenneth J. Moise Jr. 
41 Fetal Platelet Disorders, 497 Dian Winkelhorst and Dick Oepkes 
42 Fetal Infections, 508 Guillaume Benoist, Marianne Leruez-Ville and Yves Ville 
43 Disorders of Amniotic Fluid, 526 Jan E. Dickinson 
44 Multiple Pregnancy, 532 
   Sieglinde M.Mulllers, Fionnuala McAuliffe and Fergal D. Malone 
45 In Utero Stem Cell Transplantation, 554 
   Cecilia Gotherstrom, Lilian Walther-Jallow and Magnus Westgren 
46 Fetal Gene Therapy, 560 Anna L. David 
47 The Developmental Origins of Health and Disease, 572 
   Scott W. White, Sara L. Hillman and John P. Newnham

Section 9: Interface of Maternal, Fetal and

Neonatal Medicine

48 Pharmacokinetics and Pharmacodynamics, 581 
   Lara S. Lemon, Raman Venkataramanan and Steve N. Caritis 
49 Neonatal Management and Outcome in Extreme Prematurity, 588 
   Enrico Lopriore, Arjan B. Te Pas, Sylke Steggerda and
   Jeanine M. van Klink 

Online Materials
Self-Assessment 
Spyros Bakalis, Frederick Ushakov and Pranav P. Pandya 
Index, 597