Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy 4/e

Highly regarded by both students and instructors, Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and
systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps
first- and second-year students grasp challenging concepts quickly and efficiently. Each section presents
the pharmacology of a physiologic or biochemical system, followed by the pharmacology of a particular aspect
of that system; a clinical vignette; a discussion of the biochemistry, physiology, and pathophysiology of the
system; and the drugs and drug classes that activate or inhibit the system by interacting with specific
molecular and cellular targets. Clear, concise illustrations highlight key points, and drug summary tables
offer quick access to essential information.

The Fourth Edition features:
Comprehensive updates to all chapters, including recently approved drugs
Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications,
serious and common adverse effects, contraindications, and therapeutic considerations
A new chapter on drug transporters, and extensively revised information on drug-receptor interactions,
pharmacodynamics, drug toxicity, and pharmacogenomics
Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework
for material in all subsequent chapters.[MH1]
Hundreds of meticulously updated and colorized illustrations, including many that are new or substantially
modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms




Section I. Fundamental principles of pharmacology

Section II. Principles of Neuropharmacology

Section IIA. Fundamental Principles of Neuropharmacology

Section IIB. Principles of Autuonomic and Peripheral Nervous System Pharmacology

Section IIC. Principles of Central Nervous System Pharmacology

Section III. Principles of Cadiovascular Pharmacology

Section IV. Principles of Endocrine Pharmacology

Section V. Principles of Chemotherapy

Section VI. Principles of Inflammation and Immune Pharmacology

Section VII. Environmental Toxicology

Section IIA. Fundamentals of Drug Development and regulation