Abeloff's Clinical Oncology-6판

Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our 
understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, 
new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading 
cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration 
on diagnosis, staging, treatment and follow up.

　•　Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone 
　　 chapter on lifestyles and cancer prevention.
　•　Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and 
  　 clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging.
　•　Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and 
　　 radiation oncology therapies, stressing a multispecialty, integrated approach to care.
　•　Helps you find information quickly with updated indexing related to management recommendations, focused 
　　 fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board 
　　 review, and algorithms for patient evaluation, diagnosis, and treatment options.
　•　Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness 
　　 and cancer survivorship.
　•　Discusses today’s key topics such as immuno-oncology, functional imaging, precision medicine, the 
　　 application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of 
　　 chronic infectious diseases such as HIV and cancer.
　•　Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the 
　　 text, figures, and references from the book on a variety of devices.




PART I　Science and Clinical Oncology

　Section A　Biology and Cancer

　　1. Molecular Tools in Cancer Research, 2
　　2. Intracellular Signaling, 24
　　3. The Cellular Microenvironment and Metastases. 47
　　4. Control of the Cell Cycle, 56
　　5. Pathophysiology of Cancer Cell Death, 74
　　6. Cancer Immunology, 84
　　7. Stem Cells, Cell Differentiation, and Cancer, 97
　　8. Tumor Microenvironment: Vascular and Extravascular Compartment, 108
　　9. Cancer Metabolism, 127

　Section B　Genesis of Cancer

　　10. Environmental Factors, 139
　　11. DNA Damage Response Pathways and Cancer, 154
　　12. Viruses and Human Cancer, 165
　　13. Genetic Factors: Hereditary Cancer Predisposition Syndromes, 180
　　14. Genetic and Epigenetic Changes in Cancer, 209

　Section C　Diagnosis of Cancer

　　15. Pathology, Biomarkers, and Molecular Diagnostics, 225
　　16. Imaging, 254

　Section D　Clinical Trials

　　17. Biostatistics and Bioinformatics in Clinical Trials, 284
　　18. Clinical Trial Designs in Oncology, 296
　　19. Structures Supporting Cancer Clinical Trials, 308
　　20. Oncology and Health Care Policy, 317

　Section E　Prevention and Early Detection

　　21. Discovery and Characterization of Cancer Genetic Susceptibility Alleles, 323
　　22. Lifestyle and Cancer Prevention, 337
　　23. Screening and Early Detection, 375
　　24. Nicotine Dependence: Current Treatments and Future Directions, 399

　Section F　Treatment

　　25. Cancer Pharmacology, 411
　　26. Therapeutic Targeting of Cancer Cells: Era of Molecularly Targeted Agents, 420
　　27. Basics of Radiation Therapy, 431
　　28. Hematopoietic Stem Cell Transplantation, 461
　　29. Gene Therapy in Oncology, 470
　　30. Therapeutic Antibodies and Immunologic Conjugates, 486
　　31. Complementary and Alternative Medicine, 500


PART II　Problems Common to Cancer and Therapy

　Section A　Hematologic Problems and Infections

　　32. Disorders of Blood Cell Production in Clinical Oncology, 514
　　33. Diagnosis, Treatment, and Prevention of Cancer-Related Venous Thrombosis, 523
　　34. Infection in the Patient with Cancer, 544

　Section B　Symptom Management

　　35. Hypercalcemia, 565
　　36. Tumor Lysis Syndrome, 572
　　37. Cancer-Related Pain, 581
　　38. Cancer Cachexia, 593
　　39. Nausea and Vomiting, 598

　Section C　Treatment Complications

　　40. Oral Complications, 607
　　41. Dermatologic Toxicities of Anticancer Therapy, 621
　　42. Cardiovascular Effects of Cancer Therapy, 649
　　43. Reproductive Complications, 665
　　44. Paraneoplastic Neurologic Syndromes, 676
　　45. Neurologic complications, 688
　　46. Endocrine Complications, 707
　　47. Pulmonary Complications of Anticancer Treatment, 715

　Section D　Posttreatment Considerations

　　48. Rehabilitation of Individuals with Cancer, 725
　　49. Survivorship, 732
　　50. Second Malignant Neoplasms, 741
　　51. Caring for Patients at the End of Life, 751

　Section E　Local Effects of Cancer and Its Metastasis

　　52. Acute Abdomen, Bowel Obstruction, and Fistula, 764
　　53. Superior Vena Cava Syndrome, 775
　　54. Spinal Cord Compression. 786
　　55. Brain Metastases and Neoplastic Meningitis, 794
　　56. Bone Metastases, 809
　　57. Lung Metastases, 831
　　58. Liver Metastases, 846
　　59. Malignancy-Related Effusions, 863

　Section F　Special Populations

　　60. Cancer in the Elderly: Biology, Prevention, and Treatment, 874
　　61. Special Issues in Pregnancy, 882
　　62. Human Immunodeficiency Virus (HIV) Infection and Cancer, 894


PART III　Specific Malignancies

　Section A　Central Nervous System

　　63. Cancer of the Central Nervous System, 906

　Section B　Head, Neck, and Eye

　　64. Ocular Tumors, 968
　　65. Cancer of the Head and Neck, 999

　Section CSkin

　　66. Melanoma, 1034
　　67. Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas, 1052

　Section D　Endocrine

　　68. Cancer of the Endocrine System, 1074

　Section E　Thoracic

　　69. Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer, 1108
　　70. Diseases of the Pleura and Mediastinum, 1159
　　71. Cancer of the Esophagus, 1174

　Section F　Gastrointestinal

　　72. Cancer of the Stomach, 1197
　　73. Cancer of the Small Bowel, 1211
　　74. Colon Cancer, 1219
　　75. Cancer of the Rectum, 1281
　　76. Cancer of the Anal Canal, 1300
　　77. Liver and Bile Duct Cancer, 1314
　　78. Carcinoma of the Pancreas, 1342

　Section G　Genitourinary

　　79. Cancer of the Kidney, 1361
　　80. Carcinoma of the Bladder, 1382
　　81. Prostate Cancer, 1401
　　82. Cancer of the Penis, 1433
　　83. Testicular Cancer, 1442

　Section H　Gynecological

　　84. Cancers of the Cervix, Vulva, and Vagina, 1468
　　85. Uterine Cancer, 1508
　　86. Carcinoma of the Ovaries and Fallopian Tubes, 1525
　　87. Gestational Trophoblastic Disease, 1544
　　88. Cancer of the Breast, 1560

　Section I　Sarcomas

　　89. Sarcomas of Bone, 1604
　　90. Sarcomas of Soft Tissue, 1655

　Section J　Cancer of Undefined Site of Origin

　　91. Carcinoma of Unknown Primary　1694

　Section K　Pediatrics

　　92. Pediatric Solid Tumors, 1703
　　93. Childhood Leukemia, 1748
　　94. Childhood Lymphoma, 1765

　Section L　Hematological

　　95. Acute Leukemias in Adults, 1783
　　96. Myelodysplastic Syndromes, 1798
　　97. Myeloproliferative Disorders, 1821
　　98. Chronic Myeloid Leukemia, 1836
　　99. Chronic Lymphoid Leukemias, 1850
　　100. Hairy Cell Leukemia, 1872
　　101. Multiple Myeloma and Related Disorders, 1884
　　102. Hodgkin’s Lymphoma, 1911
　　103. Non-Hodgkin Lymphoma, 1926
　　104. Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma, 1948
　　105. Adult T-Cell Leukemia-Lymphoma, 1965