Cancer Genomics for the Clinician-1판

Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer
diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are
encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and
bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis
and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included
are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted
therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved
genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers,
head and neck cancer, thyroid cancer, and many more.

Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist,
early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and
the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and
trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to
know more about their genetic predispositions to cancer and the targeted therapies that could be considered and
prescribed.


Key Features:

Describes how cancer genomics and next generation sequencing
informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types
Explains what mutations are, what tests are needed, and how to interpret the results
Provides information on FDA-approved targeted therapies
that are being used in the clinic
Covers different sequencing platforms and technologies and
how they perform in research settings
Includes access to the fully searchable eBook



Contributors

Preface

Acknowledgments

1. Genetic Alterations in Cancer - Deepali Jain, Brett H. Herzog, and Leonard B. Maggi, Jr.

2. Tumor Mutational Profiling by Next-Generation Sequencing - Samantha N. McNulty, Latisha Love-Gregory,
and Jonathan W. Heusel

3. Bioinformatics: What a Clinician Should Know - Irena Lanc and Arpad Danos

4. Tumor Heterogeneity - Alex H. Wagner, Kilannin Krysiak, Katie M. Campbell, and Erica K. Barnell

5. Epigenetic Alterations in Cancer - Erica C. Pehrsson, Hyo Sik Jang, and Ting Wang

6. Cell-Free DNA in Cancer Diagnosis and Follow Up - Bruna Pellini Ferreira and Daniel Morgensztern

7. Optimizing Targeted Therapies Using Next-Generation Sequencing - Brett H. Herzog and Saiama N. Waqar

Index