Epigenetics and Assisted Reproduction: An Introductory Guide-1판

Epigenetics is the study of how certain genes are activated without modification at the DNA sequence level, resulting
in genetically similar individuals having different clinical outcomes. As contemporary medicine increasingly aims to
personalize the medical approach to a patient's genetic profile, the factors that can affect which genes are expressed
also increase in importance and relevance to the clinician. This text from experts will give the clinician in
Reproductive Medicine a reliable grounding in current thinking and research on this fast-moving topic, with many
clinical implications.




CHAPTER 1. A Short Introduction to DNA Methylation, 1

CHAPTER 2. Epigenetic Modifications of Histones, 17

CHAPTER 3. Epigenetic Reprogramming in Early Embryo Development, 29

CHAPTER 4. Epigenetic Reprogramming of Mammalian Primordial Germ Cells, 51

CHAPTER 5. Laboratory Molecular Methodologies to Analyze DNA Methylation, 69

CHAPTER 6. Intrinsic and Extrinsic Factors That Influence Epigenetics, 99

CHAPTER 7. Epigenetic and Assisted Reproduction Epidemiological Studies, 115

CHAPTER 8. Epigenetics and Assisted Reproduction Experimental Studies: Sperm Epigenome, 131

CHAPTER 9. Epigenetic and Assisted Reproduction Experimental Studies: Sperm ncRNAs, 143

CHAPTER 10. Epigenetic and Assisted Reproduction Experimental Studies: Ovarian Stimulation, 157

CHAPTER 11. Epigenetic and Assisted Reproduction Experimental Studies: In Vitro Culture, 169

CHAPTER 12. Epigenetics: Hope against Genetic Determinism, 183

CHAPTER 13. Future Perspectives, 189