Langman`s Medical Embryology-14판

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Vibrantly illustrated with full-color diagrams and clinical images, Langman's Medical Embryology, 14th Edition
helps medical, nursing, and health professions students confidently develop a basic understanding of embryology
and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a
clear, concise writing style make the subject matter accessible and engaging to students throughout their courses.
　•　Updated content reflects the latest clinical findings on the effects of the Zika virus, urogenital system
　　 disorders, and more.
　•　Clinical Correlates boxes tie clinically relevant content to case-based scenarios students may encounter in
　　 practice.
　•　More than 400 full-color illustrations, micrographs, and clinical images clarify key aspects of embryonic 　
　　 development.
　•　Problems to Solve with accompanying answers help assess student understanding.
　•　Chapter summaries and an expanded glossary reinforce understanding of key development stages, terms, and
　　 clinical conditions.
　•　Illustrated Development Chart provides visually guides students through the stages of embryonic development at a
　　 glance.
　•　Updated online review questions with answers help students test their understanding and identify areas of 　
　　 weakness.




Part 1. General Embryology

　Chapter 1. Introduction to Molecular Regulation and Signaling,　3
　　Gene Transcription,　3
　　Other Regulators of Gene Expression,　5
　　Induction and Organ Formation,　6
　　Cell Signaling,　6
　　Key Signaling Pathways for Development,　8
　　Summary,　10

　Chapter 2. Gametogenesis: Conversion of Germ Cells into Male and Female Gametes,　14
　　Primordial Germ Cells,　14
　　The Chromosome Theory of Ingeritance,　15
　　Morphological Changes during Maturation of the Gametes,　25
　　Summary,　32

　Chapter 3. First Week of Development: Ovulation to Implantation,　34
　　Ovarian Cycle,　34
　　Fertilization,　38
　　Cleavage,　42
　　Blastocyst Formation,　43
　　Epiblast, Hypoblast, and Axis Formation,　44
　　Uterus at Time of Implantation,　46
　　Summary,　48

　Chapter 4. Second Week of Development: Bilaminar Germ Disc,　50
　　Day 8,　50
　　Day 9,　51
　　Days 11 and 12,　52
　　Day 13,　53
　　Summary,　57

　Chapter 5. Third Week of Development: Trilaminar Germ Disc,　59
　　Gastrulation: Formation of Embryonic Mesoderm and Endoderm,　59
　　Formation of the Notochord,　59
　　Establishment of the Body Axes,　60
　　Fate Map Established during Gastrulation,　65
　　Growth of the Embryonic Disc,　65
　　Further Development of the Trophoblast,　68
　　Summary,　69

　Chapter 6. Third to Eighth Weeks: The Embryonic Period,　72
　　Derivatives of the Ectodermal Germ Layer,　72
　　Derivatives of the Mesodermal Germ Layer,　80
　　Derivatives of the Endodermal Germ Layer,　87
　　Patterning of the Anteroposterior Axis: Regulation by Homeobox Genes,　89
　　External Appearance during the Second Month,　90
　　Summary,　93

　Chapter 7. The Gut Tube and the Body Cavities,　96
　　A Tube on Top of a Tube,　96
　　Formation of the Body Cavity,　97
　　Serous Membranes,　97
　　Diaphragm and Thoracic Cavity,　101
　　Formation of the Diaphragm,　102
　　Summary,　104

　Chapter 8. Third Month to Birth: The Fetus and Placenta,　106
　　Development of the Fetus,　106
　　Fetal Membranes and Placenta,　110
　　Chorion Frondosum and Decidua Basalis,　113
　　Structure of the Placenta,　113
　　Amnion and Umbilical Cord,　118
　　Placental Changes at the End of Pregnancy,　119
　　Amniotic Fluid,　119
　　Fetal Membranes in Twins,　121
　　Parturition (Birth),　121
　　Summary,　126

　Chapter 9. Birth Defects and Prenatal Diagnosis,　128
　　Birth Defects,　128
　　Prenatal Diagnosis,　139
　　Fetal Therapy,　143
　　Summary,　143


Part 2. Systems-Based Embryology

　Chapter 10. The Axial Skeleton,　147
　　Skull,　147
　　Vertebrae and the Vertebral Column,　156
　　Ribs and Sternum,　158
　　Summary,　159

　Chapter 11. Muscular System,　160
　　Striated Skeletal Musculature,　160
　　Innervation of Axial Skeletal Muscles,　161
　　Skeletal Muscle and Tendons,　163
　　Molecular Regulation of Muscle Development,　163
　　Patterning of Muscles,　163
　　Head Musculature, 　163
　　Limb Musculature,　163
　　Cardiac Muscle,　164
　　Smooth Muscle,　164
　　Summary,　165

　Chapter 12. Limbs,　167
　　Limb Growth and Development,　167
　　Limb Musculature,　170
　　Summary,　178

　Chapter 13. Cardiovascular System,　179
　　Establishment and Patterning of the Primary Heart Field,　179
　　Formation and Position of the Heart Tube,　181
　　Formation of the Cardiac Loop,　183
　　Molecular Regulation of Cardiac Development,　186
　　Development of the Sinus Venosus,　187
　　Formation of the Cardiac Septa,　188
　　Formation of the Conducting System of the Heart,　205
　　Vascular Development,　206
　　Circulation Before and After Birth,　216
　　Summary,　219

　Chapter 14. Respiratory System,　223
　　Formation of the Lung Buds,　223
　　Larynx,　225
　　Trachea, Bronchi, and Lungs,　225
　　Maturation of the Lungs,　227
　　Summary,　228

　Chapter 15. Digestive System,　230
　　Divisions of the Gut Tube,　230
　　Molecular Regulation of Gut Tube Development,　231
　　Mesentery,　232
　　Foregut,　233
　　Molecular Regulation of Liver Induction,　242
　　Pancreas,　244
　　Midgut,　244
　　Hindgut,　248
　　Summary,　254

　Chapter 16. Urogenital System,　256
　　Urinary System,　256
　　Genital System,　267
　　Summary,　282

　Chapter 17. Head and Neck,　284
　　Pharyngeal Arches,　286
　　Pharyngeal Pouches,　290
　　Pharyngeal Clefts,　291
　　Molecular Regulation of Facial Development,　292
　　Tongue,　297
　　Thyroid Gland,　298
　　Face,　300
　　Intermaxillary Segment,　301
　　Secondary Palate,　301
　　Nasal Cavities,　302
　　Teeth,　302
　　Molecular Regulation of Tooth Development,　310
　　Summary,　311

　Chapter 18. Central Nervous System,　313
　　Spinal Cord,　314
　　Brain,　324
　　Molecular Regulation of Brain Development,　336
　　Cranial Nerves,　338
　　Autonomic Nervous System,　342
　　Summary,　349

　Chapter 19. Ear,　351
　　Internal Ear,　351
　　Middle Ear,　354
　　External Ear,　356
　　Hearing,　356
　　Summary,　359

　Chapter 20. Eye,　360
　　Optic Cup and Lens Vesicle,　360
　　Retina, Iris, and Ciliary Body,　362
　　Lens,　362
　　Choroid, Sclera, and Cornea,　364
　　Vitreous Body,　364
　　Optic Nerve,　365
　　Molecular Regulation of Eye Development,　365
　　Summary,　369

　Chapter 21. Integumentary System,　370
　　Skin,　370
　　Hair,　372
　　Fingernails and Toenails,　373
　　Sweat Glands,　373
　　Mammary Glands,　373
　　Summary,　375


Part 3. Appendix

　Answers to Problems,　379
　　Figure Credits,　391
　　Glossary of Key Terms,　397
　　Index,　411