The first edition of The Bethesda System for Reporting Thyroid Cytopathology was published in 2010 and has greatly
influenced the practice of thyroid cytopathology. The terminology proposed and illustrated in this text has been widely
adopted not only in the U.S. but also abroad. It has become an essential text for pathology trainees and practicing
pathologists examining thyroid fine needle aspiration (FNA) specimens.
Since 2010, there have been a number of important advances in the management of patients with nodular thyroid disease
and in the understanding of the biology of thyroid cancer. This new edition includes these advances that impact
terminology for reporting thyroid cytopathology. In particular, it incorporates a discussion of the recently
implemented and now widespread use of molecular testing of thyroid FNA samples, which has transformed the management of
patients with nodular thyroid disease in the U.S.. In addition, this edition accommodates the recent changes to the
classification of thyroid cancer, most notably the introduction of a new thyroid diagnosis, that of "non-invasive
follicular tumor with papillary-like nuclear features (NIFTP)".
Thoroughly revised and updated, The Bethesda System for Reporting Thyroid Cytopathology, Second Edition will provide
the reader with a unified approach to diagnosing and reporting thyroid FNA interpretations. It serves as a reference
guide not just for pathologists, but also endocrinologists, surgeons, and radiologists.
Overview of Diagnostic Terminology and Reporting
Nondiagnostic/Unsatisfactory
Benign
Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance
Follicular Neoplasm/Suspicious for a Follicular Neoplasm
Follicular Neoplasm, Hürthle Cell (Oncocytic) Type/Suspicious for a Follicular Neoplasm, Hürthle Cell (Oncocytic) Type
Suspicious for Malignancy
Papillary Thyroid Carcinoma, Variants, and Related Tumors
Medullary Thyroid Carcinoma
Poorly Differentiated Thyroid Carcinoma
Undifferentiated (Anaplastic) Carcinoma and Squamous Cell Carcinoma of the Thyroid
Metastatic Tumors, Lymphomas, and Rare Tumors of the Thyroid
Back Matter