Red Book 2018-2021: Report of the Committee on Infectious Diseases-31판

Extending an 8-decade tradition of excellence, Red Book® provides the most reliable and clinically useful information
on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious diseases.

The 31st edition provides evidence-based guidance to practicing clinicians on pediatric infections and vaccinations
based on the recommendations of the committee as well as the combined expertise of the CDC, the FDA, and hundreds
physician contributors.

New in Red Book 2018:
All chapters were assessed for relevance given the dynamic environment in pediatric medicine today and every chapter
has been modified since the last edition
3 new chapters added (Chikungunya, Coagulase-Negative Staphylococcal Infections, and Zika).
Standardized approaches to disease prevention through immunizations, antimicrobial prophylaxis, and infection-control
practices have been updated throughout
Recommendations for the use of doxycycline have been liberalized.
References to evidence-based policy recommendations have been recommended
Appropriate chapters have been updated to be consistent with 2018 AAP and CDC vaccine recommendations, CDC
recommendations for immunization of health care personnel, and drug recommendations from 2018 Nelson's Pediatric
Antimicrobial Therapy.

Red Book® is an indispensable reference for pediatricians and pediatric infectious disease specialists and is useful
for family medicine and emergency medicine physicians as well. Public health and school health professionals, medical
residents, and students also will find it a high-yield source of pediatric infectious disease and vaccine information.



Summary of Major Changes in the 2018 Red Book

Section 1

Prologue
Sources of Vaccine Information
Discussing Vaccines with Patients and Parents
Active Immunization
Vaccine Ingredients
Vaccine Handling and Storage
Vaccine Administration
Managing Injection Pain
Scheduling Immunizations
Minimum Ages and Minimum Intervals Between Vaccine Doses
Interchangeability of Vaccine Products
Simultaneous Administration of Multiple Vaccines
Combination Vaccines
Lapsed Immunizations
Unknown or Uncertain Immunization Status
Vaccine Dose
Active Immunization of People Who Recently Received Immune Globulin and Other Blood Products
Vaccine Safety
IOM Reviews of Adverse Events After Immunization
Vaccine Adverse Event Reporting System (VAERS)
Vaccine Safety Datalink Project
Postlicensure Rapid Immunization Safety Monitoring (PRISM)
Clinical Immunization Safety Assessment (CISA) Project
Vaccine Injury Compensation
Hypersensitivity Reactions after Immunization
Passive Immunization
Immune Globulin Intramuscular (IGIM)
Immune Globulin Intravenous (IGIV)
Immune Globulin Subcutaneous (IGSC)
Treatment of Anaphylactic Reactions
Preterm and Low Birth Weight Infants
Pregnancy
Immunocompromised Children
Children With a Personal or Family History of Seizure
Children with Chronic Diseases
American Indian/Alaska Native Children
Adolescent and College Populations
Health Care Personnel
Children Who Received Immunizations Outside the US or Whose IZ Status is Unknown
International Travel

Section 2

Human Milk
Children in Out-of-Home Child Care
School Health
Infection Control and Prevention for Hospitalized Children
Infection Control and Prevention in Ambulatory Settings
Sexually Transmitted Infections in Adolescents and Children
Medical Evaluation for Infectious Diseases for Internationally Adopted, Refugee and Immigrant Children
Injuries from Discarded Needles in the Community
Bite Wounds
Prevention of Tickborne Infections
Prevention of Mosquitoborne Infections
Prevention of Illnesses Associated with Recreational Water Use

Section 3

Actinomycosis
Adenovirus Infections
Amebiasis
Amebic Meningoencephalitis and Keratitis
Anthrax
Arboviruses
Arcanobacterium haemolyticum Infections
Ascaris lumbricoides Infections
Aspergillosis
Astrovirus Infections
Babesiosis
Bacillus cereus Infections
Bacterial Vaginosis
Bacteroides and Prevotella Infections
Balantidium coli Infections (Balantidiasis)
Baylisascaris Infections
Blastocystis hominis Infections
Blastomycosis
Bocavirus
Borrelia Infections (Relapsing Fever)
Brucellosis
Burkholderia Infections
Campylobacter Infections
Candidiasis
Cat-Scratch Disease
Chancroid
Chikungunya
Chlamydial Infections, Chlamydophila (formerly Chlamydia) pneumoniae
Chlamydial Infections, Chlamydophila (formerly Chlamydia) psittaci (Psittacosis, Ornithosis, Parrot Fever)
Chlamydial Infections, Chlamydia trachomatis
Clostridial Infections, Botulism and Infant Botulism
Clostridial Infections, Clostridial Myonecrosis
Clostridial Infections, Clostridium difficile
Clostridial Infections, Clostridium perfringens Food Poisoning
Coccidiodomycosis
Coronaviruses
Cryptococcus neoformans and Cryptococcus gattii Infections
Cryptosporidiosis
Cutaneous Larva Migrans
Cyclosporiasis
Cytomegalovirus Infection
Dengue Fever
Diphtheria
Ehrlichia, Anaplasma and Related Infections
Enterovirus (Nonpoliovirus)
Epstein-Bar Virus Infections
Escherichia coli and Other Gram-Negative Bacilli
Escherichia coli Diarrhea
Fungal Diseases
Fusobacterium Infections
Giardia intestinalis Infections (Giardiasis)
Gonococcal Infections
Granuloma Inguinale
Haemophilus influenzae Infections
Hantavirus Pulmonary Syndrome
Helicobacter pylori Infections
Hemorrhagic Fevers Caused by Arenaviruses
Hemorrhagic Fevers Caused by Bunyaviruses
Hemorrhagic Fevers Caused by Filoviruses: Ebola and Marburg
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Hepatitis E
Herpes Simplex
Histoplasmosis
Hookworm Infections
Human Herpesvirus 6 (Including Roseola) and 7
Human Herpesvirus 8
Human Immunodeficiency Virus Infection
Influenza
Isosporiasis
Kawasaki Disease
Kingella kingae Infections
Legionella pneumophila Infections
Leishmaniasis
Leprosy
Leptospirosis
Listeria monocytogenes Infections
Lyme Disease
Lymphatic Filariasis
Lymphocytic Choriomeningitis
Malaria
Measles
Meningococcal Infections
Human Metapneumovirus
Microsporidia Infections
Molluscum Contagiosum
Moraxella catarrhalis Infections
Mumps
Mycoplasma pneumoniae Infections
Nocardiosis
Norovirus and Other Human Calicivirus Infections
Onchocerciasis (River Blindness, Filariasis)
Human Papillomavirus
Paracoccidioidomycosis
Paragonimiasis
Parainfluenza Viral Infections
Parasitic Diseases
Human Parechovirus Infections
Parvovirus B19
Pasteurella Infections
Pediculosis Capitis
Pediculosis Corporis
Pediculosis Pubis
Pelvic Inflammatory Disease
Pertussis (Whooping Cough)
Pinworm Infection
Pityriasis Versicolor (Tinea Versicolor)
Plague
Pneumococcal Infections
Pneumocystis jirovecci Infections
Poliovirus Infections
Polyomaviruses
Prion Diseases, Transmissible Spongiform Encephalopathies
Q Fever
Rabies
Rat-Bite Fever
Respiratory Syncytial Virus
Rhinovirus Infections
Rickettsial Diseases
Rickettsialpox
Rocky Mountain Spotted Fever
Rotavirus Infections
Rubella
Salmonella Infections
Scabies
Schistosomiasis
Shigella Infections
Smallpox (Variola)
Sporotrichosis
Staphylococcal Food Poisoning
Staphylococcus aureus (formerly known as Staphylococcal Infections)
Coagulase-negative Staphylococcal Infections
Group A Streptococcal Infections
Group B Streptococcal Infections
Non-Group A or B Streptococcal and Enterococcal Infections
Strongyloidiasis
Syphilis
Tapeworm Diseases (Taeniasis and Cysricercosis)
Other Tapeworm Infections
Tetanus
Tinea Capitis
Tinea Corporis
Tinea Cruris
Tinea Pedis and Tinea Unguium
Toxocariasis
Toxoplasma gondii Infections
Trichinellosis
Trichomonas vaginalis Infections
Trichuriasis
Africian Trypanosomiasis
American Trypanosomiasis
Tuberculosis
Diseases Caused by Nontuberculous Mycobacteria
Tularemia
Endemic Typhus (murine typhus)
Epidemic Typhus (louseborne or Sylvatic typhus)
Ureaplasma urealyticum and Ureaplasma parvum Infections
Varicella-Zoster Infections
Vibrio Infections, Cholera
Vibrio Infections, Other Vibrio Infections
West Nile Virus
Yersinia enterocolitica and Yersinia pseudotuberculosis Infections
Zika Virus

Section 4

Antimicrobial Agents and Related Therapy (AKA Introduction)
Antimicrobial Resistance and Antimicrobial Stewardship: Appropriate and Judicious Use of Antimicrobial Agents
Drug Interactions
Tables of Antibacterial Drug Doses
Sexually Transmitted Infections
Antifungal Drugs for Systemic Fungal Infections
Recommended Doses of Parenteral and Oral Antifungal Drugs
Topical Drugs for Superficial Fungal Infections
Non-HIV Antiviral Drugs
Drugs for Parasitic Infections
MEDWATCH-The FDA Safety Information and Adverse Event Reporting Program

Section 5

Antimicrobial Prophylaxis
Antimicrobial Prophylaxis in Pediatric Surgical Patients
Prevention of Bactrial Endocarditis
Prevention of Neonatal Ophthalmia

Appendices
Directory of Resources
Codes for Commonly Administered Pediatric Vaccines/Toxoids and Immune Globulins
National Childhood Vaccine Injury Act Reporting and Compensation Table
Nationally Notifiable Infectious Diseases in the United States
Guide to Contraindications and Precautions to Immunizations
Prevention of Disease From Potentially Contaminated Food Products
Clinical Syndromes Associated with Foodborne Diseases
Diseases Transmitted by Animals (Zoonoses)