The Molecular Basis of Cancer: Expert Consult - Online and Print 4e

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against
cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current
understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts
thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions
now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common
cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in
everyday clinical application.

Part I: Carcinogenesis and Cancer Genetics

1. Cancer, A Genetic Disorder

2. Oncogenes and Signal Transduction

3. Tumor Suppressor Genes

4. Genomic Instability and DNA Repair

5. Epigenetics and Cancer

6. Infectious Agents and Cancer

7. Environmental Carcinogenesis

8. Animal Models: Flies, Fish and Yeast

9. Genetic Mouse Models of Cancer


Part II: Cancer Biology

10. Cancer Stem Cells

11. Regulation of the Cell Cycle

12. Cell Growth

13. Cancer Cell Metabolism

14. Apoptosis, Autophagy and Necrosis

15. Cell Growth Arrest and Senescence

16. Stromal-Cancer Interactions in the Microenvironment

17. Hypoxia and Angiogenesis

18. Invasion and Metastasis

19. Inflammation and Cancer

20. Molecular Pathways and Systems Biology


Part III: Molecular Pathology and Diagnostics

21. Biomarkers Assessing Risk of Cancer

22. Biomarkers for Detecting Cancer: Molecular Screening

23. Biomarkers for Predicting Response to Specific Therapy

24. The Technology of Analyzing Nucleic Acids

25. Imaging Cancer