Williams Hematology 9E

The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees
in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant
disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource,
with editors who are internationally regarded for their research and clinical achievements and authors who are
luminaries in their fields.

The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science,
translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color
presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing
that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the
relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell
morphology important to diagnosis.

Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to
the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders
of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases,
hemostasis and thrombosis, and transfusion medicine.


Table of contents

1

Initial approach to the patient: History and physical examination

2

Examination of blood cells

3

Examination of the marrow

4

Consultative Hematology

5

Structure of the marrow and hematopoietic microenvironment

6

The organization and structure of lymphoid tissues

7

Hematology of the fetus and newborn

8

Hematology during pregnancy

9

Hematology in older persons

10

Genetic principles

11

Genomics

12

Epigenetics

13

Cytogenetic and Genetic Abnormalities

14

Metabolism of Hematological Neoplastic Cells

15

Apoptosis and Autophagy

16

Cell cycle regulation and hematological disorders

17

Signal transduction pathways

18

Hematopoietic stem cells, progenitors, and cytokines

19

The inflammatory response

20

Innate immunity

21

Adaptive immunity

22

Pharmacology and toxicity of antineoplastic drugs

23

Hematopoietic stem cell transplantation

24

Treatment of infections in the immunocompromised host


25

Antithrombotic therapy

26

Immune cell therapy

27

Vaccine therapy


28

Therapeutic apheresis: indications, efficacy, and complications


29

Gene transfer for therapy


30

Regenerative Medicine: Multipotential cell therapy for tissue replacement


31

Structure and Composition of the Erythrocyte

Absorb former 30 Composition of Erythrocyte.

32

Erythropoiesis


33

Erythrocytes turnover


34

Clinical manifestations and classification of erythrocyte disorders

35

Aplastic anemia


36

Pure red cell aplasia

37

Anemia of chronic disease

38

Erythropoietic effects of endocrine disorders


39

The congenital dyserythropoietic anemias

40

Paroxysmal nocturnal hemoglobinuria

41

Folate, cobalamin and megaloblastic anemias

42

Iron Metabolism


43

Iron deficiency and overload

44

Anemia resulting from other nutritional deficiencies

45

Anemia associated with marrow infiltration

46

Erythrocyte Membrane Disorders


47

Erythrocyte Enzyme Disorders

48

The thalassemias

49

Disorders of hemoglobin structure: sickle cell anemia and related abnormalities

50

Methemoglobinemia and other dyshemoglobinemias

51

Fragmentation hemolytic anemia


52

Erythrocyte disorders as a result of chemical and physical agents

53

Hemolytic anemia due to infections with microorganisms

54

Immune Hemolytic Anemia

55

Alloimmune hemolytic disease of the fetus and newborn

56

Hypersplenism and hyposplenism

57

Primary and Secondary Polycythemias

58

The porphyrias

59

Hereditary and acquired (polyclonal) sideroblastic anemias

60

Structure and composition of neutrophils, eosinophils, and basophils


Composition of neutrophils

Absorbed into chapter 60

61

Production, distribution, and fate of neutrophils

62

Eosinophils and their disorders

63

Basophils and mast cells, and their disorders

64

Classification and clinical manifestations of neutrophil disorders

65

Neutropenia and neutrophilia

66

Disorders of neutrophil function

67

Structure, biochemistry, and function of monocytes and macrophages


Biochemistry and function of monocytes and macrophages ABSORBED into Chap 67.

68

Production, distribution, and fate of monocytes and macrophages

69

Classification and clinical manifestations of disorders of monocytes and macrophages

70

Monocytosis and monocytopenia

71

Inflammatory and malignant histiocytosis

72

Gaucher Disease and Related Lysosomal Storage Diseases

73

Structure, composition, and biochemistry of lymphocytes and plasma cells



Composition and biochemistry of lymphocytes and plasma cells ABSORBED into Chap 73.

74

Lymphopoiesis

75

Functions of B lymphocytes and plasma cells in immunoglobin production

76

Functions of T lymphocytes: T-cell receptors for antigen

77

Functions of natural killer cells

78

Classification and clinical manifestations of lymphocyte and plasma cell disorders


79

Lymphocytosis and lymphocytopenia

80

Immunodeficiency diseases

81

Hematological manifestations of acquired immunodeficiency syndrome (AIDS)

82

Mononucleosis syndromes

83

Classification and clinical manifestations of the clonal myeloid disorders

84

Polycythemia vera

85

Essential thrombocythemia

86

Primary myelofibrosis


87

Myelodysplastic disorders (Clonal cytopenias and oligoblastic leukemia)

88




Author comments

Kenneth Kaushansky, MD (Stony Brook, NY) is Senior Vice President, Health Sciences and Dean of the School of Medicine,
Stony Brook University.


Marshall A. Lichtman, MD (Rochester, NY) is Professor of Medicine and of Biochemistry and Biophysics, University of
Rochester Medical Center.


Josef T. Prchal, MD (Salt Lake City, UT, and Prague, Czech Republic) is Professor of Medicine, Pathology, and Genetics,
Hematology Division of the University of Utah, and Department of Pathophysiology, First Faculty of Medicine, Charles
University in Prague.


Marcel M. Levi, MD, PhD (Amsterdam, The Netherlands) is Chairman of the Department of Medicine at the Academic Medical
Center, University of Amsterdam.


Oliver W. Press, MD, PhD (Seattle, WA) is Member and Penny E. Petersen Endowed Chair of Lymphoma Research, Fred
Hutchinson Cancer Research Center, Professor of Medicine at the University of Washington.


Linda J. Burns, MD (Minneapolis, MN) is Vice President and Medical Director, Health Services Research at National
Marrow Donor Program/Be The Match.


Michael A. Caligiuri, MD (Columbus, OH) is Director, Comprehensive Cancer Center, CEO, James Cancer Hospital & Solove
Research Institute, JL Marakas Nationwide Insurance Enterprise Foundation Chair of Cancer Research, The Ohio State
University.