Intrauterine Insemination

Intrauterine insemination (IUI), also known as artificial insemination, is a fertility treatment that uses a catheter



to place washed sperm directly into the uterus. Its aim is to increase the number of sperm reaching the fallopian tubes



and subsequently increase the chances of fertilisation (American Pregnancy Association).















The second edition of Intrauterine Insemination brings physicians and trainees fully up to date with the latest



developments in the technique.















Divided into 48 chapters, this comprehensive guide covers every aspect of the procedure, from patient selection and



clinical assessment of couples, to ovarian induction, predictors of ovarian response, modulation of sperm motility, and



sperm banking. The final sections describe data management issues, sex pre-selection, and regulation of assisted



reproductive technologies.































Key points







•New edition presenting latest developments in IUI







•Covers all aspects of the procedure







•Includes more than 150 images, illustrations and tables







•Previous edition published in 2005























Author information















Gautam N Allahbadia MD DNB FNAMS







Consultant Fertility Physician, Dr LH Hiranandani Centre for Human Reproduction, Mumbai; Director IVF, The Prince Aly



Khan Centre for Human Reproduction, Mumbai; Scientific Director, Rotunda - The Centre for Human Reproduction, Mumbai,



India















Rubina Merchant MD







Deccan Fertility Clinic, Rotunda – The Centre for Human Reproduction, Mumbai, India























Table of Contents







 Molecular Regulation of Key Events that Play a Role in Successful Mammalian Fertilization







 Spermatogenesis, Sperm Maturation and Sperm-Oocyte Interaction in Human







 Patient Selection and Management to Optimize Success in an Intrauterine Insemination







Program







 IUI: Indications, Results and Outcomes







 Intrauterine Insemination as a Treatment Option in Resource Limited Medical Settings







 First-line Treatment for Unexplained Infertility in Women over 40 Years of Age-ovulation







Induction and IUI, or IVF?







 Ovulation Induction for IUI







 Predictors of Ovarian Response to Stimulation for Intrauterine Insemination







 Role of Recombinant Gonadotropins in an IUI Program—Current Protocols







 Recombinant FSH versus Clomiphene Citrate for Ovarian Stimulation in Couples with







Unexplained Infertility and Male Subfertility Undergoing IUI







 The use of GnRH Antagonists in Ovarian Stimulation for Intrauterine Insemination







 Clomiphene Citrate Stimulated or Natural Cycle IUI?







 Aromatase Inhibitors versus Clomiphene Citrate for Superovulation in Patients with







Unexplained Infertility Undergoing IUI







 Strategies in Prevention of the Ovarian Hyperstimulation Syndrome







 Efficacy of Unstimulated Intrauterine Insemination in Advanced Age Women







 How to Set Up a Laboratory for an IUI Program







 Novel Methods for Sperm Separation and Isolation







 Intrauterine Insemination Techniques







 The Influence of Timing Intrauterine Insemination and the Number of Inseminations on







Pregnancy Outcome







 Single versus Double Intrauterine Insemination in Multi-follicular Ovarian Hyperstimulation







Cycles







 Endometrial Thickness and Pregnancy Outcome after Intrauterine Insemination







 Ultrasound in the Investigation and Monitoring of Infertility







 Can Periovulatory Follicular Volumen and Vascularization Determined by 3D and Power







Doppler Sonography Predict the IUI Outcome?







 Evaluation of the Impact of Sperm Characteristics on the Outcome of Intrauterine







Insemination







 Modulation of Sperm Motility







 The Physiology of the Spermatozoon and the use of Digitally Enhanced Sperm Analysis in







Predicting Pregnancy after Intrauterine Insemination







 Effect of Swim-up and Gradient as Semen Preparation Techniques on the Outcome of







Intrauterine Insemination







 Effect of Male Factor on Pregnancy Outcome in Patients Undergoing Intrauterine







Insemination







 Sperm Surface Antibodies: IUI or IVF







 Luteal Phase Support during Intrauterine Insemination Cycles-does it Influence the







Outcome?







 Luteal Phase Support in Stimulated Intrauterine Insemination Cycles: Is there a Need for it?







 Efficacy and Safety of IUI in HIV Serodiscordant Couples where the Man is Positive







 Complications of Intrauterine Insemination







 Stimulated IVF with Elective Single Embryo Transfer Versus IUI for Unexplained Subfertility







 Goals and Significance of Semen Cryopreservation for IUI







 Human Sperm Banking







 The Value of Semen Cryopreservation Combined with IUI for Infertile Men with







Oligozoospermia and Asthenozoospermia







 Assessment of Sperm Cryodamage and Strategies to Improve Outcome







 The Significance of Excess Oocyte Aspiration and Vitrification in Patients Undergoing







Stimulated IUI







 IVF Conversion to IUI in Poor Responders to Gonadotropin Stimulation: Is it Advantageous?







 Intrauterine Insemination versus Fallopian Tube Sperm Perfusion for Non-tubal Subfertility







 The Role of the Andrologist in an Intrauterine Insemination Program







 Role of the Nurse Coordinator in an IUI Program







 Data Management for an IUI Clinic







 Is there a Role for Intrauterine Insemination in the 2000’s?







 Computerization of an Andrology and IUI Program







 Sex Pre selection; A Never Ending Story







 Regulation of Assisted Reproductive Technologies Including IUI Programs