Brenner and Rector's The Kidney 10/e(2Vols)

Overcome the toughest clinical challenges in nephrology with Brenner & Rector’s The Kidney the most well-known
nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest
knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical
best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career.

New to This Edition

Internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors. An
editorial team headed by Dr. Skorecki and handpicked by Dr. Brenner ensures the ongoing adherence to previous standards
of excellence. All chapters have been extensively d or entirely rewritten by authorities in their respective fields.

The latest clinical information including recent clinical trials, genetic causes of kidney disease, cardiovascular and
renal risk prediction in chronic kidney disease, new paradigms in fluid and electrolyte management, and pediatric
kidney disease, keep you current with the rapid development of care and research worldwide.


Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the
text, figures, and references from the book on a variety of devices.
Key Features


Review of the basic science that underpins clinical nephrology, comprehensive ion of the most important bibliographical
sources in nephrology, and Board Review-style questions help you prepare for certification or recertification.

Coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and
into old age. Expanded sections and chapter on global perspective and ethical considerations.


Uniform terminology and nomenclature in line with emerging consensus in world kidney community.


More than 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and s to illustrate
essential concepts, nuances of clinical presentation and technique, and decision making provide a visual grasp and
better understanding of critical information.



Section I: Normal Structure and Function

1 Embryology of the Kidney

2 Anatomy of the Kidney

3 The Renal Circulations and Glomerular Ultrafiltration

4 The Podocyte

5 Metabolic Basis of Solute Transport

6 Transport of Sodium, Chloride, and Potassium

7 The Regulation of Calcium, Magnesium, and Phosphate Excretion by the Kidney

8 Renal Handling of Organic Solutes

9 Renal Acidification Mechanisms

10 Urine Concentration and Dilution

11 The Cell Biology of Vasopressin Action

12 Aldosterone and Mineralocorticoid Receptors: Renal and Extrarenal Roles

13 Vasoactive Molecules and the Kidney

14 Arachidonic Acid Metabolites and the Kidney


Section II: Disorders of Body Fluid Volume and Composition

15 Disorders of Sodium Balance

16 Disorders of Water Balance

17 Disorders of Acid-Base Balance

18 Disorders of Potassium Balance

19 Disorders of Calcium, Magnesium, and Phosphate Balance


Section III: Epidemiology and Risk Factors in Kidney Disease

20 Epidemiology of Kidney Disease

21 Demographics of Kidney Disease

22 Risk Factors and Chronic Kidney Disease

23 Nephron Endowment and Developmental Programming of Blood Pressure and Renal Function

24 Aging and Kidney Disease


Section IV: Evaluation of the Patient with Kidney Disease

25 Approach to the Patient with Kidney Disease

26 Laboratory Assessment of Kidney Disease: Glomerular Filtration Rate, Urinalysis, and Proteinuria

27 Interpretation of Electrolyte and Acid-Base Parameters in Blood and Urine

28 Diagnostic Kidney Imaging

29 The Kidney Biopsy

30 Biomarkers in Acute and Chronic Kidney Diseases


Section V: Disorders of Kidney Structure and Function

31 Acute Kidney Injury

32 Primary Glomerular Disease

33 Secondary Glomerular Disease

34 Overview of Therapy for Glomerular Disease

35 Microvascular and Macrovascular Diseases of the Kidney

36 Tubulointerstitial Diseases

37 Urinary Tract Infection in Adults

38 Urinary Tract Obstruction

39 Diabetic Nephropathy

40 Urolithiasis

41 Kidney Cancer

42 Onco-Nephrology: Kidney Disease in Patients with Cancer


Section VI: Genetics of Kidney Disease

43 Genetic Basis of Kidney Disease

44 Inherited Disorders of the Glomerulus

45 Inherited Disorders of the Renal Tubule

46 Cystic Diseases of the Kidney


Section VII: Hypertension and the Kidney

47 Primary and Secondary Hypertension

48 Renovascular Hypertension and Ischemic Nephropathy

49 Hypertension and Kidney Disease in Pregnancy

50 Antihypertensive Therapy

51 Diuretics


Section VIII: The Consequences of Advanced Kidney Disease

52 Adaptation to Nephron Loss and Mechanisms of Progression in Chronic Kidney Disease

53 Mechanisms and Consequences of Proteinuria

54 The Pathophysiology of Uremia

55 Chronic Kidney Disease-Mineral Bone Disorder

56 Cardiovascular Aspects of Kidney Disease

57 Hematologic Aspects of Kidney Disease

58 Endocrine Aspects of Chronic Kidney Disease

59 Neurologic Aspects of Kidney Disease

60 Dermatologic Conditions in Kidney Disease


Section IX: Conservative Management of Kidney Disease

61 Dietary Approaches to Kidney Diseases

62 A Stepped Care Approach to the Management of Chronic Kidney Disease

63 Therapeutic Approach to Chronic Kidney Disease-Mineral and Bone Disorder

64 Drug Dosing Considerations in Patients with Acute Kidney Injury and Chronic Kidney Disease


Section X: Dialysis and Extracorporeal Therapies

65 Hemodialysis

66 Peritoneal Dialysis

67 Critical Care Nephrology

68 Plasmapheresis

69 Elimination Enhancement of Poisons

70 Interventional Nephrology


Section XI: Kidney Transplantation

71 Transplantation Immunobiology

72 Clinical Management of the Adult Kidney Transplant Recipient


Section XII: Pediatric Nephrology

73 Malformation of the Kidney: Structural and Functional Consequences

74 Diseases of the Kidney and Urinary Tract in Children

75 Fluid, Electrolyte, and Acid-Base Disorders in Children

76 Renal Replacement Therapy (Dialysis and Transplantation) in Pediatric End-Stage Kidney Disease


Section XIII: Global Considerations in Kidney Disease

77 Latin America

78 Africa

79 Near and Middle East

80 Indian Subcontinent

81 The Far East

82 Oceania Region


Section XIV: Challenges in Nephrology

83 Ethical Dilemmas Facing Nephrology: Past, Present, and Future

84 Health Disparities in Nephrology

85 Care of the Older Person with Chronic Kidney Disease

86 Tissue Engineering, Stem Cells, and Cell Therapy in Nephrology

87 Quality Improvement Initiatives in Kidney Disease