Part I: Critical Care Integration
Section I: Introduction to the Practice of Pediatric Critical Care
Editors: Kissoon, Nichols
1. Pediatric Critical Care: A Global Perspective
Trevor Duke, Niranjan "Tex" Kissoon, Edwin van der Voort, Bo Sun, Jefferson Piva
2. Impact of Pediatric Critical Care on the Family, Community, and Society
Lewis H. Romer, David G. Nichols, Jessica Mesman, Heather Woods Barthel, Matt Norvell, Melissa J. Sacco, Khaliah
Johnson, and Jos M. Latour
Section II: Professionalism, Leadership, and Systems-Based Practice
Editors: Argent, Davis
3. Professionalism and Leadership
Alice D. Ackerman, Vinay Nadkarni,
4. Simulation Training and Team Dynamics
Elizabeth Hunt, Peter Weinstock, David Grant , Vinay Nadkarni?, Jason Custer, Mark Rosen
5. Physical Design and Personnel Organization
M. Michele Moss, Shari Simone
6. Practice Management: The Business of Pediatric Critical Care
Alice D. Ackerman
7. Research Design and Statistical Analysis
Wynne E. Morrison, Elizabeth A. Hunt, J. Michael Dean, and Anne-Marie Guerguerian
8. Evidence-Based Medicine
Barry P. Markovitz, Kathleen L. Meert
9. Quality Improvement, Patient Safety, and Medical Error
Andrew C. Argent, Vicki L. Montgomery
Section III: Information Management
Editor: Wetzel
10. Severity of Illness Measurement: Foundations, Principles, and Applications
Anthony D. Slonim, James P. Marcin, and Murray M. Pollack
11. Communication and Information Management in the PICU
Steven Pon and Barry Markovitz
12. Outcomes and Research
Randall Wetzel, Ramesh Sachdeva
Section IV: Ethical and Palliative Concerns in the Care of the Critically Ill
Editors: Burns, Yaster
13. Integrating Palliative Care and Critical Care
Wynne Morrision, Patricia Lago, Jefferson Piva, Kathleen Meert
14. Pain and Sedation Management
Myron Yaster, R. Blaine Easley, Kenneth M. Brady, Sapna Kudchadkar
15. Ethics
George E. Hardart, Denis J. Devictor
16. Organ Donation
Kristin L. Nelson, Ivor D. Berkowitz, Tom Nakagawa
17. Rehabilitation
Melissa K. Trovato, Glendaliz Bosques, Robert J. Graham, Megan Kramer, Frank S. Pidcock, Suzanne Prestwich, Cristina
Sadowsky, Scott C. Schultz
Section V: Basic Science Concepts of Pediatric Critical Care
Editor: Wong
18. Genetics and "'Omics"
Mary K. Dahmer, Michael Quasney
19. Innate Immunity and Inflammation
James A. Thomas
20. Cellular Adaptations to Stress
Derek S. Wheeler, Hector R. Wong
21. Shock, Ischemia, and Reperfusion Injury
Basilia Zingarelli
22. Pharmacology
Athena F. Zuppa
23. Multiple Organ Dysfunction Syndrome
Scott L. Weiss, Yong Y. Han, Thomas P. Shanley, and Joseph A. Carcillo
Part II: Emergency Care and Acute Management
Section I: Initial Stabilization
Editors: Kissoon, Nadkarni
24. Airway Management
All de Caen, Jonathan Duff, Ashraf H. Coovadia, Robert Luten, Ann E. Thompson, Mary Fran Hazinski
25. Cardiopulmonary Resuscitation
Robert A. Berg, Katsuyuki Miyasaka, Antonio Rodriguez-Nunez, Mary Fran Hazinski, David Zideman, Vinay M. Nadkarni
26. Transport
Monica E. Kleinman, Aaron J. Donoghue, Richard A. Orr, Niranjan "Tex" Kissoon
27. Invasive Procedures
Stephen M. Schexnayder, Praveen Khilnani, Naoki Shimizu, Arno L. Zaritsky
28. Recognition and Initial Management of Critical Illness and Shock
Simon Nadel, Niranjan "Tex" Kissoon, Suchitra Ranjit, Kathy Maitland
29. Rapid Response Systems
Christopher P. Bonafide, Richard J. Brilli, James Tibballs, Christopher S. Parshuram, Patrick W. Brady, and Derek
Wheeler
Section II: Environmental Crises
Editor: Schleien
30. Multiple Trauma
J. Scott Baird, Arthur Cooper
31. Drowning and Near Drowning: Submersion Injuries
Katherine Biagas, Linda Aponte, Steve Kernie
32. Burns, Electrical Injuries, and Smoke Inhalation
Roger W. Yurt, Joy D. Howell, Bruce M. Greenwald, James Gallagher
33. Bioterrorism
George L. Foltin, F. Meridith Sonnett, Pete Silver
34. Mass Casualty Events
Christopher Watson, Nanette Esperanza
35. Poisoning
G. Patricia Cantwell, Richard S. Weisman, Michael Nares
36. Thermoregulation
Charles Schleien and Adnan Bakar
37. Envenomation Syndromes
James Tibballs, Kenneth D. Winkel
Section III: Life-Support Technologies
Editors: Dalton, Lacroix, MacLaren
38. Mechanical Ventilation
Mark J. Heulitt, Gerhard K. Wolf, John H. Arnold, Ira M. Cheifetz, Jim Fortenberry
39. Inhaled Gases
Angela T. Wratney, Donna S. Hamel, Ira M. Cheifetz
40. Extracorporeal Life Support
Graeme MacLaren, Steven A. Conrad, Heidi J. Dalton
41. Organ Replacement Therapy
Warwick W. Butt, Peter W. Skippen, Phillippe Jouvet, Jim Fortenberry
42. Blood Products and Transfusion Therapy
Phil Spinella, Naomi L.C. Luban, Edward C.C. Wong, Oliver Karam
Part III: Critical Care Organ Systems
Section I: Respiratory Disease
Editors: Bohn, Arnold, Sun
43. Respiratory Physiology
Frank L. Powell, Gregory P. Heldt, Gabriel G. Haddad
44. The Molecular Biology of Acute Lung Injury
Todd Carpenter and Kurt R. Stenmark
45. Respiratory Monitoring
Ira M. Cheifetz, Shekhar T. Venkataraman, Donna S. Hamel
46. Status Asthmaticus
Michael T. Bingham, Richard J. Brilli
47. Neonatal Respiratory Failure
Elisabeth L. Raab, Lisa K. Kelly, Philippe S. Friedlich, Rangasamy Ramanathan, Istvan Seri
48. Bronchiolitis and Pneumonia
Werther Brunow de Carvalho, Cintia Johnston, Marcelo Cunio Machado Fonseca
49. Acute Lung Injury and Acute Respiratory Distress Syndrome
Kathleen M. Ventre, John H. Arnold
50. Chronic Respiratory Failure
Thomas G. Keens, Sheila S. Kun, Sally L. Davidson Ward
51. Sleep and Breathing
Sally L. Davidson Ward, Thomas G. Keens
Section II: Neuromuscular Disease
Editor: Tasker
52. Peripheral Neurophysiology
Matthew Pitt
53. Acute Neuromuscular Diseases
Sunit Singhi, Alka Khadwal, Arun Bansal
54. Chronic Neuromuscular Diseases
Jonathan Gillis, Monique M. Ryan, Elena Cavazzoni
Section III: Neurologic Disease
Editors: Kochanek, Tasker
55. Developmental Neurobiology, Neurophysiology and the PICU
Larry W. Jenkins, Patrick M. Kochanek
56. Molecular Biology of Brain Injury
Patrick M. Kochanek, Hulya Bayir, Larry W. Jenkins, Robert S.B. Clark
57. Evaluation of the Comatose Child
Nicholas S. Abend, Sudha Kilaru Kessler, Mark A. Helfaer, Daniel J. Licht
58. Neurologic Monitoring
Mateo Aboy, Alan Graham, Robert Tasker
59. Neurologic Imaging
David Joshua Michelson, Stephen Ashwal
60. Neurosurgical and Neuroradiological Critical Care
Michael McManus and Craig McClain
61. Head and Spinal Cord Trauma
Robert C. Tasker, David Adelson
62. Abusive Head Trauma
Rachel P. Berger, Dennis Simon, Jennifer E. Wolford, Michael J. Bell
63. Status Epilepticus
Kimberly S. Bennett, Colin B. Van Orman
64. Cerebrovascular Disease and Stroke
John Pappachan, Fenella Kirkham
65. Hypoxic-Ischemic Encephalopathy
Ericka L. Fink, Mioara D. Manole, Robert S.B. Clark
66. Metabolic Encephalopathy
Phillippe Jouvet, Anne Lortie, Bruno Maranda, Robert C. Tasker, Genevieve Dupont-Thibodeau, Laurence Ducharme-Crevier
67. The Determination of Brain Death
Thomas A. Nakagawa and Mudit Mathur
Section IV: Cardiovascular Disease
Editors: Checchia, Nichols
68. Cardiac Anatomy
Steven M. Schwartz, Zdenek Slavik, Siew Yen Ho
69. Cardiovascular Physiology
Peter E. Oishi, Rebecca Johnson, Jeffrey R. Fineman
70. Cardiorespiratory Interactions
Lara Shekerdemian, Ron Bronicki
71. Hemodynamic Monitoring
Neil Spenceley, Ron Bronicki
72. Heart Failure: Etiology, Pathophysiology, and Diagnosis
Mary E. McBride, John M. Costello, Conrad L. Epting
73. Cardiomyopathy and Myocarditis
Bill Harmon, Bridgite Stiller, Aparna Hoskote
74. Treatment of Heart Failure: Medical Management
Joseph W. Rossano, Jack F. Price, David P. Nelson
75. Treatment of Heart Failure: Mechanical Support
Iki Adachi, Lara Shekerdemian, Paul A. Checchia, Charles Fraser
76. Thoracic Transplantation
Steven A. Webber, Laura Loftis, Paul Aurora, Nikoleta Kolovos
77. Cardiac Conduction, Dysrhythmias, and Pacing
Bradley S. Marino, Jonathan R. Kaltman, Ronn E. Tanel
78. Preoperative Cardiac Surgical Care
David L. Wessel, Alain Fraisse, Sophie Arnaud
79. Postoperative Cardiac Surgical Care
Ron Bronicki, Kate Brown, John Costello, David Wessel
80. Pulmonary Hypertension
John K. McGuire, Silvia Hartman, and Apichai Khongphatthanayothin
Section V: Immunologic Diseases
Editors: Carcillo, Volk
81. The Immune System
Meredith L. Allen, Nigel J. Klein, Mark J. Peters
82. Neurohormonal Control in the Immune System
Kathryn A. Felmet
83. The Polymorphonuclear Leukocyte
M. Michele Mariscalco
84. The Immune System and Viral Illness
Lesley Doughty
85. Immune-modulation and Immunotherapy
Mark W. Hall
86. Immunology of Cancer and Primary Immune Deficiency Syndromes
Tracy Fausnight, Jennifer A. McArthur, Sachin S. Jogal, Robert F. Tamburro
Section VI: Infectious Diseases
Editors: Hall, Singhi
87. Bacterial Sepsis and Mechanisms of Microbial Pathogenesis
Neal J. Thomas, Robert F. Tamburro, Mark W. Hall, Surender Rajasekaran, John S. Venglarcik
88. Principles of Anti-microbial Therapy
Todd Karsies, Kevin Spicer, Lulu Jin, Cheryl Sargel, Mark hall
89. Dengue and Other Viral Hemorrhagic Viral Infections
Siripen Kalayanarooj, Rakesh Lodha
90. Critical Viral Infections
Rakesh Lodha, Sunit C. Singhi, and James D. Campbell
91. Central Nervous System Infections
Pratibha D. Singhi, Sunit C. Singhi, Charles RJC Newton
92. Nosocomial Infections
John P. Straumanis
93. International and Emerging Infections
Troy E. Dominguez, Chitra Ravishankar, Miriam K. Laufer
94. Toxin-related Diseases
Sunit C. Singhi, M. Jayashree, John P. Straumanis, Karen L. Kotloff
95. Opportunistic Infections
Sushil K. Kabra and Matthew B. Laurens
Section VII: Nutritional and Gastrointestinal Disorders
Editors: Duncan, Mehta
96. Principles of GI Physiology, Nutrition, and Metabolism
Patrick O'Neal Maynord , Z. Leah Harris
97. Nutritional Support
Werther Brunow de Carvalho, Artur F. Delgado, and Heitor Pons Leite,
98. Secretory and Motility Issues of the GI Tract
Samuel Nurko
99. Gastrointestinal Bleeding
Douglas Fishman, Sabina Mir
100. Abdominal Compartment Syndrome
Mudit Mathur and J. Chiaka Ejike
101. The Acute Abdomen
Eduardo Schnitzler, Tomas Iolster, Ricardo D. Russo
102. Diagnostic Imaging of the Abdomen
Rebecca Hulett, Swapnil Bagade
103. Fulminant Hepatic Failure and Transplantation
Pierre Tissieres, Denis J. Devictor
104. Pediatric Intestinal and Multivisceral Transplantation
Geoffrey J. Bond, Kathryn Felmet, Ronald Jaffe, Kyle Soltys, Jeffrey A. Rudolph, Dolly Martin, Rakesh Sindhi, and
George V. Mazariegos
Section VIII: Renal, Endocrine, and Metabolic Disorders
Editors: Biagas, Schleien
105. Adrenal Dysfunction
Sharon E. Oberfield, Abeer Hassoun
106. Disorders of Glucose Homeostasis
Stuart A. Weinzimer, Michael F. Canarie, Edward Vincent S. Faustino, William V. Tamborlane, Clifford W. Bogue
107. Disorders of Water, Sodium and Potassium Homeostasis
Andrea Kelly, Thomas Moshang, Jr, James Schneider
108. Disorders of Calcium, Phosphates, and Magnesium
Kenneth Banasiak, Dennis Carey
109. Thyroid Disease
Ori Eyal, Susan R. Rose
110. Acute Kidney Injury
Christine Sethna
111. End-Stage Renal Disease and Renal Transplantation
Fangming Lin, Modini Vinai, Robert Woroniecki, Kimberly Reidy
112. Hypertensive Crises
George Ofori-Amanfo, Arthur Smerling, Charlie Schleien
113. Inborn Errors of Metabolism
Michael Wilhelm, Wendy Chung
Section IX: Oncologic and Hematologic Disorders
Editor: Tobias
114. Cancer Therapy for the Pediatric Intensivist
David M. Loeb and Masanori Hayashi
115. Oncologic Emergencies and Complications
Rodrigo Mejia, Nidra Rodriguez, Jose Cortes, Sanju Samuel, Fernando F. Corrales-Medina, Regina Okhuysen, Rizalina
Mauricio, and Winston Huh
116. Hematologic Emergencies
R. Blaine Easley, Kenneth M. Brady, Joseph D. Tobias, Michael McCrory
117. Bone Marrow and Stem Cell Transplantation
Monica Bhatia, Mitch Cairo, Katherine Biagas
118. Coagulation Issues in the PICU
Robert I. Parker and David G. Nichols
119. Sickle Cell Disease
Kevin J. Sullivan, Erin Coletti, Salvatore R. Goodwin, Cynthia Gauger, and Niranjan "Tex" Kissoon
Appendix
Pediatric Critical Care Formulas