Handbook of Veterinary Pharmacology

Book Description





I am grateful for the constructive suggestions I have received from students, readers, and colleagues for the firrst
edition of Handbook of Veterinary Pharmacology. I want to thank Professor Fahd Z. Eissa especially for his thorough
review of the book and comments. In response to these suggestions, and in light of the many important changes that have
occurred across the landscape of veterinary pharmacology and therapeutics over the past five years, we have made a
number of significant improvements in the second edition of the book. I hope and expect that the following additions
will aid students and faculty in the learning and teaching of veterinary pharmacology:

?Thanks to the contribution by Dr. Brett A. Sponseller and Dr. Beatrice T. Sponseller, a chapter on immunostimulants
and immunomodulators (Chapter 8) has been added to the book.

?We expand the concept of P-glycoprotein in the drug eux mechanism for many drugs in Chapter 1. There is more and
more appreciation of the P-glycoprotein in pumping out an

array of chemicals across the cell membranes of the organisms. Interestingly, this protein is also involved in the
development of drug resistance by microorganisms.

?Comprehensive updating of all chapters and appendices (withdrawal time charts and dosage table) including new drugs
approved by the FDA through 2012 and drugs that are frequently used in other parts of the world but not in the U.S.

?Comprehensive updating of many gures and tables with addition of 23 gures over the rst edition of the book (from
60 gures in the rst edition to 83 gures in the second edition).

?Creation of the chapter outline with page number listed for each subject heading.










Table of Contents



Contributors viii

Preface xii

1. Principles of Drug Absorption,

Drug Disposition and Drug Action 1

Richard J. Martin, Walter H. Hsu, and Steve A. Carlson

2. Drugs Affecting Peripheral Nervous System 37

Walter H. Hsu and Carrie A. Berg

3. Drugs Acting on the Central Nervous System 77

Walter H. Hsu and Dean H. Riedesel

4. Behavior-Modifying Drugs 115

Arthi Kanthasamy, Walter H. Hsu, and Carrie A. Berg

5. Anesthetics 141

Dean H. Riedesel

6. Autacoids And Their Pharmacological Modulators 169

Anumantha G. Kanthasamy and Walter H. Hsu

7. Nonsteroidal Anti-Inflammatory Drugs 195

Walter H. Hsu and Arthi Kanthasamy

8. Immunostimulants and Immunomodulators 217

Brett A. Sponseller and Beatrice T. Sponseller

9. Endocrine Pharmacology 235

Walter H. Hsu

10. Drugs Acting on the Cardiovascular System 277

Wendy A. Ware

11. Respiratory Pharmacology 321

Dean H. Riedesel

12. Gastrointestinal Pharmacology 337

Albert E. Jergens

13. Diuretics 367

Anumantha G. Kanthasamy and Franklin A. Ahrens

14. Fluid and Blood Therapy 383

Walter H. Hsu and Karl W. Bolser

15. Topical Dermatology Therapy 411