Stem Cell and Gene-Based Therapy

The human body is unable to significantly self-repair injured organs and tissues, resulting in
a considerable medical and social problem. During the last few years there has been incredible progress,
and achievements in experimental strategies for tissue regeneration have led to potential treatment
options for many otherwise fatal conditions. This multidisciplinary book offers a new approach for
restoring functions of damaged organs and tissues. Several books have been published on particular
aspects of organ and/or tissue replacement, but none cover the major new aspects and field of regenerative medicine.
This title is therefore a timely addition to the literature, bringing together the major approaches
to regenerative medicine and ensuring that techniques learnt in one discipline are disseminated across other areas.
Practitioners will gain knowledge of how regenerative medicine applies to their discipline directly as well as how
it could benefit their patients in the future.



Section 1 Heart
1 Renovation of the Injured Heart with Myocardial Tissue Engineering
2 Adult Stem Cells for Myocardial Tissue Repair
3 Regeneration of the Functional Myocardium Using Human Embryonic Stem Cells
4 Therapeutic Angiogenesis
5 Cell Therapy for Heart Failure

Section 2 Neuro
6 Cell Transplantation for Diseases of Myelin
7 Stem Cells as a Source for Cell Replacement in Parkinson's Disease
8 Cell Replacement Therapy in Acute Stroke: Current State
9 Gene Therapy to the Nervous System

Section 3 Musculoskeletal
10 Mesenchymal Stem Cells: Where Can You Find Them? How Can You Use Them?
11 Basic to Clinical Cartilage Engineering: Past, Present, and Future Discussions
12 Cartilage
13 Bone Regeneration
14 Osteoarthritis and Mesenchymal Cells The Prospects for Repair of the Disease by Cell Trans

Section 4 Kidney
15 Progenitor Cell Therapy for Kidney Regeneration
16 Tissue Engineering ?The Bladder

Section 5 Eye
17 Neuroprotection in Ophthalmology: A Review
18 Autoimmunity for Central Nervous System Maintenance, Regeneration, and Renewal
19 Retinal Repair by Stem Cell Transplantation
20 Induction of Ocular Surface Regeneration

Section 6 Pancreas
21 Insulin-Producing Cells Generated from Nonpancreatic Tissues
22 Generation of Islets from Pancreatic Progenitor Cells
23 Embryonic Stem Cells as a Source of Pancreatic Precursors and Islet Cells In Vitro

Section 7 Hematology
24 Human Umbilical Cord Blood Transplantation: A Viable Option for Stem Cell Graft
25 Nonmyeloablative Stem Cell Transplantation in the Treatment of Hematologic Malignancies
26 Hematopoietic Stem Cell Transplantation from Human Leukocyte Antigen Haploidentical Don

Section 8 Skin
27 Wound Healing and Skin Substitutes
28 Skin Regeneration from Multipotent Adult and Embryonic Stem Cells

Index