The Vein Book 2/e

Fully updated from the previous edition to include recent discoveries in the field, technological advances, and new
venous procedures
The must-have resource on the condition and treatment of varicose veins, spider veins, and thread veins

Since its initial publication nearly a decade ago, The Vein Book continues to serves as the ultimate comprehensive
resource on venous disease. Upholding its reputation as the go-to reference for complete, authoritative, and up-to-
date
information about venous function and dysfunction, this second edition effectively bridges the gap between clinical
medicine and basic science, suitable both for the seasoned surgeon as well as the medical student.



Table of Contents
Part I: Basic Considerations

1. Historical Introduction
Alberto Caggiati and Claudio Allegra

2. Venous Embryology and Anatomy
Geza Mozes and Peter Gloviczki

3. Epidemiology of Chronic Peripheral Venous Disease
Michael H. Criqui, Julie O. Denenberg, Robert D. Langer, Robert M. Kaplan, and Arnost Fronek

4. Venous Anatomy, Physiology, and Pathophysiology
John J. Bergan and Luigi Pascarella

5. Role of Physiologic Testing in Venous Disorders
Jeffrey K. Raines and Jose I. Almeida

6. Inappropriate Leukocyte Activation in Venous Disease
Philip Coleridge Smith

7. Chronic Venous Insufficiency: Molecular Abnormalities and Ulcer Formation
Joseph D. Raffetto

8. Pathophysiology of Chronic Venous Insufficiency
Peter J. Pappas, Brajesh K. Lal, Frank T. Padberg Jr., Robert W. Zickler, and Walter N. Duran

9. Mechanism and Effects of Compression Therapy
Hugo Partsch

10. Classifying Venous Disease
Bo Elkof

Part II: Primary Superficial Venous Insufficiency

11. Risk Factors, Manifestations, and Clinic Examination of the Patient with Primary Venous Insufficiency
John J. Bergan

12. Sclerosing Agents
A. Cavezzi and M. Izzo

13. Sclerotherapy Treatment of Telangiectasias
Robert A. Weiss and Margaret A. Weiss

14. Complications and Adverse Sequelae of Sclerotherapy
Mitchel P. Goldman

15. Laser Treatment of Telangiectasias and Reticular Veins
Neil Sadick and Lian Sorhaindo

16. Overview: Treatment of Venous Insufficiency
John J. Bergan

17. Ultrasound Examination of the Patient with Primary Venous Insufficiency
Luigi Pascarella and Lisa Mekenas

18. Sclerotherapy and Ultrasound Sclerotherapy
Paul K. Thibault

19. Sclerofoam for Treatment of Varicose Veins
Jeanjerome Guex

20. Sclerosants in Microfoam: A New Approach in Angiology
Juan Cabrera, Maria V. Rubia, and Juan Cabrera Jr.

21. Ultrasound Guided Catheter and Foam Therapy for Venous Insufficiency
Luigi Pascarella and John J. Bergan

22. Principles of Treatment of Varicose Veins
Steven E. Zimmet

23. Inversion Stripping of the Saphenous Vein
John J. Bergan

24. Neovascularization: An Adverse Response to Proper Groin Dissection
Marianne De Maeseneer

25. The Changing Importance of the Saphenous Vein: Treating vs. Non-treatment
Paul Pittaluga, Chastanet S, Locret T

26. Principles of Ambulatory Phlebectomy
Jose I. Almeida and Jeffrey K. Raines

27. Powered Phlebectomy in Surgery of Varicose Veins
Nick Morrison

28. Endovenous Radiofrequency and Laser Ablation
Nick Morrison

29. Treatment of Small Saphenous Vein Reflux
Kenneth Myers, Amy Clough, Stefania Roberts, and Damien Jolley

30. Recurrent Varicose Veins After Operative Treatment
Michel Perrin

31. Use of System-Specific Questionnaires and Determination of Quality of Life After Treatment of Varicose Veins
A C Shepherd, M Davis, and A H Davies

32. Pelvic Congestion Syndrome: Diagnosis and Treatment
G D Richardson

Part III: Venous Thromboembolism

33. The Epidemiology of Venous Thromboembolism in the Community: Implications for Prevention and Management
John A. Heit

34. Fundamental Mechanisms in Venous Thrombosis: New Insights
Jose A. Diaz, Daniel D. Myers Jr., and Thomas W. Wakefield

35. Congenital and Acquired Hypercoagulable Syndromes
Jocelyn A. Segall and Timothy K. Liem

36. New Ways To Prevent Venous Thromboembolism: Inhibition of Factor Xa and Thrombin
David Bergqvist

37. Diagnosis of Deep Venous Thrombosis
David A. Frankel and Warner P. Bundens

38. Thrombotic Risk Assessment: A Hybrid Approach
Joseph A. Caprini

39. Venous Thromboembolism Prophylaxis in the General Surgical Patient
J.I. Arcelus and Joseph A. Caprini

40. Conventional Treatment of Deep Venous Thrombosis
Graham F. Pineo and Russell D. Hull

41. The Diagnosis and Management of Heparin-Induced Thrombocytopenia
Theodore E. Warkentin

42. Operative Venous Thrombectomy
Anthony J. Comerota and Steven S. Gale

43. Permanent Vena Cava Filters: Indications, Filter Types, and Results
Ali F. AbuRahma and Patrick A. Stone

44. Complications of Vena Cava Filters
Teresa L. Carman and Linda M. Graham

45. Temporary Filters and Prophylactic Indications
John C. McCallum and Nikhil Kansal

46. Thrombolytic Therapy for Acute Venous Thrombosis
Anthony J. Comerota and Santiago Chahwan

47. Percutaneous Mechanical Thrombectomy in the Treatment of DVT
Colleen M. Johnson, Pritham P. Reddy, and Robert B. McLafferty

48. Diagnosis and Management of Primary Axillo-Subclavian Venous Thrombosis
Niren Angle

49. Subclavian Vein Obstruction: Techniques for Repair and Bypass
Richard J. Sanders

50. Superficial Thrombophlebitis: Recommendations for Diagnosis and Management
Joann M. Lohr

Part IV: Chronic Venous Insufficiency

51. The Primary Cause of Chronic Venous Insufficiency
Michel Perrin, Oscar Maleti, and Marzia Lugli

52. Conventional Surgery for Chronic Venous Insufficiency
William Marston

53. Subfascial Endoscopic Perforating Vein Surgery (SEPS) for Chronic Venous Insufficiency
Peter Gloviczki, Manju Karla, and Alessandra Puggioni

54. Ultrasound Guided Sclerotherapy of Perforating Veins In Chronic Insufficiency
Fedor Lurie, Alessandra Puggionu, and Robert L. Kistner

55. Perforating Veins
John J. Bergan and Luigi Pascarella

56. Endovenous Treatment of Iliocaval Occlusion
Patricia E. Thorpe and Francisco J. Osse

57. Popliteal Venous Entrapment
Seshadri Raju

58. Valvuloplasy In Primary Venous Insufficiency: Development, Performance, and Long-Term Results
Robert L. Kistner, Elna Masuda, and Fedor Lurie

59. Prosthetic Venous Valves
Michael C. Dalsing

60. Post-Thrombotic Syndrome: Clinical Features, Pathology, and Treatment
Seshadri Raju

61. Efficacy of Veno-Active Drugs In Chronic Venous Disease: Survey Of Evidence, Synthesis, And Tentative
Recommendations
Michel Perrin and A.A. Ramelet

62. Medical Management of the Venous Leg Ulcer: Wound Dressings and Adjuvant Agents

Part V: Congenital Venous Abnormalities

63. Venous Malformations and Tumors: Etiology, Diagnosis, and Management
BB Lee and J Laredo