Wintrobe's Clinical Hematology,13/e
With the 13th edition of Wintrobe’s Clinical Hematology, this new edition once again bridges the gap between the
clinical practice of hematology and the basic foundations of science.
Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The
Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders
of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections,
there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other
tissues.
With the knowledge about gene therapy and immunotherapy expanding, the book includes new, up-to-date information about
the process and application of these therapies. Likewise, the editors have shed a completely new light on the process
of stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the
importance of long-term follow-up of transplantation survivors.
The textbook features an online, interactive companion that has a reference list for each chapter as well as two
appendices one reviewing the clusters of differentiation (CD) molecules and one that reviews lab values and
photomicrographs of the blood of animals.
Along with these tools, the authors plan to post updates online when they are particularly pertinent or important.
Features:
Greater emphasis on molecular genetics and flow cytometry
Increased number of hematopathology illustrations
Expanded coverage of Transplantation
Online companion with reference features and relevant updates
Table of Contents
VOLUME 1
PART I Laboratory Hematology
CH 1. Examination of the Blood and Bone Marrow
CH 2. Clinical Flow Cytometry
CH 3. Cytogenetics
CH 4. Molecular Biology and Hematology
PART II The Normal Hematologic System
Section 1. Hematopoiesis
CH 5. Origin and Development of Blood Cells
Section 2. The Erythrocyte
CH 6. Erythropoiesis
CH 7. The Mature Erythrocyte
CH 8. Destruction of Erythrocytes
Section 3. Granulocytes and Monocytes
CH 9. Neutrophilic Leukocytes
CH 10. The Human Eosinophil
CH 11. Basophilic Leukocytes: Mast Cells and Basophils
CH 12. Mononuclear Phagocytes
CH 13. Phagocytosis
Section 4. The Lymphocytes
CH 14. Lymphocytes and Lymphatic Organs
CH 15. B Lymphocytes
CH 16. T Lymphocytes and Natural Killer Cells
CH 17. Effector Mechanisms in Immunity
Section 5. Hemostasis
CH 18. Megakaryocytes
CH 19. Platelet Structure and Function in Hemostasis and Thrombosis
CH 20. Blood Coagulation and Fibrinolysis
CH 21. Endothelium: Angiogenesis and the Regulation of Hemostasis
PART III Therapeutic Modalities
CH 22. Red Cell, Platelet, and White Cell Antigens
CH 23. Transfusion Medicine
CH 24. Hematopoietic Stem Cell Transplantation
CH 25. Gene Therapy for Hematologic Disorders
PART IV Disorders of Red Cells
Section 1. Introduction
CH 26. Anemia: General Considerations
Section 2. Disorders of Iron Metabolism and Heme Synthesis
CH 27. Iron Deficiency and Related Disorders
CH 28. Sideroblastic Anemias
CH 29. Hemochromatosis
CH 30. Porphyria
Section 3. Hemolytic Anemia
CH 31. Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated with Abnormalities of the
Erythrocyte Membrane
CH 32. Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders
CH 33. Autoimmune Hemolytic Anemia
CH 34. Alloimmune Hemolytic Disease of the Fetus and Newborn
CH 35. Paroxysmal Nocturnal Hemoglobinuria
CH 36. Acquired Nonimmune Hemolytic Disorders
Section 4. Hereditary Disorders of Hemoglobin Structure and Synthesis
CH 37. Sickle Cell Anemia and Other Sickling Syndromes
CH 38. Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis
CH 39. Hemoglobins with Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias
Section 5. Other Red Cells Disorders
CH 40. Megaloblastic Anemias: Disorders of Impaired DNA Synthesis
CH 41. Inherited Aplastic Anemia Syndromes
CH 42. Acquired Aplastic Anemia
CH 43. Red Cell Aplasia
CH 44. Congenital Dyserythropoietic Anemias
CH 45. Anemias Secondary to Chronic Disease and Systemic Disorders
CH 46. Anemias During Pregnancy and the Postpartum Period
CH 47. Anemias Unique to the Newborn Period
CH 48. Erythrocytosis
V O L U M E 2
PART V Disorders of Hemostasis and Coagulation
Section 1. Introduction
Section 2. Thrombocytopenia
Section 3. Other Disorders of Primary Hemostasis
Section 4. Coagulation Disorders Platelet Destruction
Section 5 Thrombosis
PART VI Nonmalignant Disorders of Leukocytes,the Spleen, and/or Immunoglobins
PART VII Hematologic Malignancies
Section 1. General Aspects
Section 2. The Acute Leukemias
Section 4. Lymphoproliferative Disorders
Section 5. Plasma Cell Dyscrasias
Appendices
INDEX