Thomas Hematopoietic Cell Transplantation 4/e

This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This
fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations,
including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per
year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry

The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his
discoveries concerning organ and cell transplantation in the treatment of human diseases.


The book also now includes a fully searchable CD with PDFs of the entire content.


Table of Contents
Contributors.
Preface to the First Edition.

Preface to the Second Edition.

Preface to the Third Edition.

Preface to the Fourth Edition.

Thomas HCT Fourth Edition.

List of Abbreviations.

SECTION 1.

History and Use of Hematopoietic Cell.

Transplantation.

1 A History of Allogeneic Hematopoietic Cell Transplantation.

E. Donnall Thomas.

2 The History of Autologous Hematopoietic Cell Transplantation.

James O. Armitage.

3 Uses and Growth of Hematopoietic Cell Transplantation.

Mary M. Horowitz.

SECTION 2.

Scientific Basis for Hematopoietic Cell Transplantation.

Section 2a.

Hematopoiesis and Stem Cell Biology.

4 Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Embryonic Stem Cells.

Laurence Dah?on & David T. Scadden.

5 Biology of Hematopoietic Stem and Progenitor Cells.

Susan Prohaska & Irving Weissman.

6 Molecular Biology of Stem Cell Renewal.

Peter M. Lansdorp.

7 Cellular Biology of Hematopoiesis.

Catherine M. Flynn & Catherine M. Verfaillie.

8 Expansion of Hematopoietic Stem Cells.

Colleen Delaney & Irwin Bernstein.

9 Mesenchymal Stromal Cells and Hematopoietic Cell ransplantation.

Edwin M. Horwitz.

10 Genetic Manipulation of Hematopoietic Stem Cells.

Grant D. Trobridge & Hans-Peter Kiem.

Section 2b.

Immunology.

11 Overview of Hematopoietic Cell Transplantation Immunology.

Paul J. Martin.

12 Histocompatibility.

Eric Mickelson & Effi e W. Petersdorf.

13 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation.

Michael R. Verneris & Jeffrey S. Miller.

14 Murine Models of Graft-versus-Host Disease and Graft-versus-Tumor Effect.

Robert Korngold & Thea M. Friedman.

15 Mechanisms of Tolerance.

Megan Sykes.

16 The Pathophysiology of Graft-Versus-Host Disease.

James L.M. Ferrara & Joseph H. Antin.

17 Immune Reconstitution Following Hematopoietic Cell Transplantation.

Robertson Parkman & Kenneth I. Weinberg.

18 The Human Graft-versus-Tumor Response ?and How to Exploit It.

Edus H. Warren.

19 Dendritic Cells in Hematopoietic Cell Transplantation.

Miriam Merad, Matthew P. Collin & Edgar G. Engleman.

20 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases.

Judith A. Shizuru.

Section 2c.

Technical Aspects.

21 Pharmacologic Basis for High-dose Chemotherapy.

James H. Doroshow & Timothy W. Synold.

22 High-dose Preparatory Regimens.

William I. Bensinger.

23 Radiotherapeutic Principles of Hematopoietic Cell Transplantation.

Jeffrey Y.C. Wong & Timothy Schultheiss.

24 Radioimmunotherapy and Hematopoietic Cell Transplantation.

Damian J. Green & Oliver W. Press.

25 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation.

Paul J. Martin.

26 The Detection and Signifi cance of Minimal Residual Disease.

Jerald P. Radich & Marilyn L. Slovak.

27 Pathology of Hematopoietic Cell Transplantation.

Howard M. Shulman, Robert C. Hackman & George E. Sale.

28 Biostatistical Methods in Hematopoietic Cell Transplantation.

Joyce C. Niland & Paul Frankel.

29 Outcomes Research in Hematopoietic Cell Transplantation.

Stephanie J. Lee.

SECTION 3.

Patient-oriented Issues in Hematopoietic Cell Transplantation.

30 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation.

Karl G. Blume & Robert A. Krance.

31 Nursing Role in Hematopoietic Cell Transplantation.

Rosemary C. Ford & Mihkaila M. Wickline.

32 Ethical Issues in Hematopoietic Cell Transplantation.

David S. Snyder.

33 Psychosocial Issues in Hematopoietic Cell Transplantation.

Richard P. McQuellon & Michael Andrykowski.

34 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients.

Karen L. Syrjala & Samantha Burns Artherholt.

35 Sexuality Following Hematopoietic Cell Transplantation: An Important Health-related Quality of Life Issue.

D. Kathryn Tierney.

36 Hematopoietic Cell Transplantation: The Patient뭩 Perspective.

Susan K. Stewart.

SECTION 4.

Sources of Hematopoietic Cells for Hematopoietic Cell Transplantation.

37 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation.

Phyllis I. Warkentin & Elizabeth J. Shpall.

38 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries.

Dennis L. Confer, John P. Miller & Jeffrey W. Chell.

39 Cord Blood Hematopoietic Cell Transplantation.

Hal E. Broxmeyer & Franklin O. Smith.

40 In Utero Transplantation.

Alan W. Flake & Esmail D. Zanjani.

41 Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Cellular Therapy.

Thomas C. Shea & John F. DiPersio.

42 Removal of Tumor Cells from the Hematopoietic Graft.

John G. Gribben.

43 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation.

Norbert Schmitz.

44 Cryopreservation of Hematopoietic Cells.

Scott D. Rowley.

45 Use of Recombinant Growth Factors After Hematopoietic Cell Transplantation.

J?gen Finke & Roland Mertelsmann.

46 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors.

Claudio Anasetti, Franco Aversa & Andrea Velardi.

47 Hematopoietic Cell Transplantation from Unrelated Donors.

Effi e W. Petersdorf.

48 Donor Selection for Hematopoietic Cell Transplantation.

Ann E. Woolfrey.

SECTION 5.

Hematopoietic Cell Transplantation for Acquired Diseases.

49 Hematopoietic Cell Transplantation for Aplastic Anemia.

George E. Georges & Rainer Storb.

50 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria.

Robert P. Witherspoon.

51 Allogeneic and Autologous Transplantation for Chronic Myeloid Leukemia.

Jerald P. Radich & Ravi Bhatia.

52 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia.

Charlotte M. Niemeyer & Franco Locatelli.

53 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia.

Frederick R. Appelbaum.

54 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia.

Julie-An M. Talano, James T. Casper & David A. Margolis.

55 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults.

Stephen J. Forman.

56 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children.

Parinda A. Mehta & Stella M. Davies.

57 Hematopoietic Cell Transplantation for Myelodysplastic Syndrome and Myeloproliferative Disorders.

H. Joachim Deeg.

58 Hematopoietic Cell Transplantation for Multiple Myeloma.

Muzaffar H. Qazilbash & Sergio A. Giralt.

59 Hematopoietic Cell Transplantation for Hodgkin뭩 Disease.

Philip J. Bierman & Auayporn Nademanee.

60 Non-Hodgkin뭩 Lymphoma.

Laura J. Johnston & Sandra J. Horning.

61 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia.

David B. Miklos.

62 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL-) Amyloidosis.

Raymond L. Comenzo & Morie A. Gertz.

63 Hematopoietic Cell Transplantation for Breast Cancer.

Yago Nieto & Elizabeth J. Shpall.

64 Hematopoietic Cell Transplantation in Germ Cell Tumors.

Christie J. Moore, Brandon Hayes-Lattin & Craig R. Nichols.

65 Hematopoietic Cell Transplantation for Renal Cell and other Solid Tumors.

Richard W. Childs & Ramaprasad Srinivasan.

66 Hematopoietic Cell Transplantation for Neuroblastoma.

Jason Law & Katherine K. Matthay.

67 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors.

David M. Loeb & Allen R. Chen.

68 Hematopoietic Cell Transplantation for Patients with Human Immunodeficiency Virus Infection.

John A. Zaia, Amrita Krishnan, & John J. Rossi.

69 Hematopoietic Cell Transplantation for Autoimmune Diseases.

Richard A. Nash.

70 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies.

Vinod Pullarkat & Stephen J. Forman.

71 Reduced-intensity Conditioning Followed by Hematopoietic Cell Transplantation for Hematologic Malignancies.

Brenda M. Sandmaier & Rainer Storb.

72 Management of Relapse after Hematopoietic Cell Transplantation.

Ginna G. Laport & Robert S. Negrin.

SECTION 6.

Hematopoietic Cell Transplantation for Inherited Diseases.

73 Hematopoietic Cell Transplantation for Thalassemia.

Guido Lucarelli & Javid Gaziev.

74 Hematopoietic Cell Transplantation for Sickle Cell Disease.

Mark C. Walters.

75 Hematopoietic Cell Transplantation for Immunodefi ciency Diseases.

Trudy N. Small, Wilhelm Friedrich, & Richard J. O뭃eilly.

76 Hematopoietic Cell Transplantation for Osteopetrosis.

Peter F. Coccia.

77 Hematopoietic Cell Transplantation for Storage Diseases.

Charles Peters.

78 Hematopoietic Cell Transplantation for Macrophage and Granulocyte Disorders.

Rajni Agarwal.

79 Hematopoietic Cell Transplantation for Fanconi뭩 Anemia.

John E. Wagner, Margaret L. MacMillan, & Arleen D. Auerbach.

SECTION 7.

Complications of Hematopoietic Cell Transplantation.

80 Mechanisms and Treatment of Graft Failure.

Robert Lowsky & Hans Messner.

81 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation.

Margaret R. O묭onnell.

82 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation.

Jeffrey McCullough.

83 Vascular Access and Complications.

I. Benjamin Paz.

84 Pharmacologic Prevention of Acute Graft-Versus-Host Disease.

Nelson J. Chao & Keith M. Sullivan.

85 T-Cell Depletion to Prevent Graft-versus-Host Disease.

Robert J. Soiffer.

86 Manifestations and Treatment of Acute Graft-Versus-Host Disease.

Corey Cutler & Joseph H. Antin.

87 Chronic Graft-versus-Host Disease: Clinical Manifestations and Therapy.

Steven Z. Pavletic & Georgia B. Vogelsang.

88 Bacterial Infections.

Helen L. Leather & John R. Wingard.

89 Fungal Infections after Hematopoietic Cell Transplantation.

Janice (Wes) M.Y. Brown.

90 Cytomegalovirus Infection.

John A. Zaia.

91 Herpes Simplex Virus Infections.

James I. Ito.

92 Varicella-zoster Virus Infections.

Dora Y. Ho & Ann M. Arvin.

93 Epstein뺹arr Virus Infection.

Wen-son Hsieh & Richard F. Ambinder.

94 Adenoviruses, Respiratory Viruses, HHV-6, HHV-7, HHV-8, Papovaviruses and Other Viruses After Hematopoietic Cell
Transplantation.

Michael Boeckh.

95 Gastrointestinal and Hepatic Complications.

Simone I. Strasser & George B. McDonald.

96 Lung Injury Following Hematopoietic Cell Transplantation.

Kenneth R. Cooke & Gregory A. Yanik.

97 Kidney and Bladder Complications of Hematopoietic Cell Transplantation.

Sangeeta Hingorani.

98 Endocrine Complications Following Hematopoietic Cell Transplantation.

Fouad R. Kandeel.

99 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation.

Anne Poon & Lowan Ly.

100 Critical Care of the Hematopoietic Cell Transplant Recipient.

Gundeep S. Dhillon & Norman W. Rizk.

101 Nutrition Support of the Hematopoietic Cell Transplant Recipient.

Polly Lenssen & Saundra Aker.

102 Pain Management.

Noelle V. Frey & Jonathan R. Gavrin.

103 Oral Complications of Hematopoietic Cell Transplantation.

Mark M. Schubert & Douglas E. Peterson.

104 Growth and Development after Hematopoietic Cell Transplantation.

Jean E. Sanders.

105 Delayed Nonmalignant Complications after Hematopoietic Cell Transplantation.

Mary E.D. Flowers & H. Joachim Deeg.

106 Secondary Malignancies after Hematopoietic Cell Transplantation.

Smita Bhatia & Ravi Bhatia.

107 Neurologic Complications of Hematopoietic Cell Transplantation.

Harry Openshaw.

108 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients.

Trudy N. Small.

SECTION 8.

Looking Forward.

109 Hematopoietic Cell Transplantation in the Future.

Ernest Beutler.

Colorplates, facing page.

Robert C. Hackman.

Index.