Principles and Practice of Gynecologic Oncology 6/e

Description
Today, multidisciplinary approaches to treatment are at the heart of cancer care. They offer improved clinical
outcomes, new possibilities in patient quality of life, and enable the development of true innovation in individualized
treatment.

To accurately reflect this modern day approach to cancer care, the content of the 6th edition of Principles and
Practice of Gynecologic Oncology was written entirely
by surgeons, medical oncologists, radiation oncologists, and pathologists. New to the editorial team, Dr. Andrew
Berchuck has made significant contributions to the understanding of the molecular pathogenesis of ovarian and
endometrial cancer in the book뭩 content.

Every chapter of this book has been either completely rewritten or extensively updated to ensure that everyone involved
in treating women with gynecologic cancer will have the most comprehensive and up-to-date information on the subject.

Traditionally available as a printed textbook, now it comes with a completely revamped digital experience, powered by
Inkling!

FEATURES:
?4-color layout with over 550 illustrations
?New chapters include 밠olecular Pathogenesis of Gynecologic Cancers? 밐ereditary GYN Cancers? 밠inimally
Invasive Surgery? 밆iagnostic Imaging? and 밅omparative Effectiveness Research in Gynecologic Oncology?
?A valuable resource for residents and fellows in training
?Digital version can be used for clinic, conferences, or as an authoritative source of knowledge available in real time
?Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into
the text, and much more


Table of Contents
Dedication v
Contributing Authors vi
Preface xi
Acknowledgments xiii
SECTION I: ETIOLOGY, PREVENTION, AND MOLECULAR BIOLOGY
1 Epidemiology of Gynecologic Cancers 1
Louise A. Brinton, Vikrant V. Sahasrabuddhe, and Britton Trabert
2 Molecular Pathogenesis of Gynecologic Cancers 30
Andrew Berchuck, Douglas A. Levine, John H. Farley, and Michael J. Birrer
3 Hereditary Gynecologic Cancers 60
Karen H. Lu, Andrew Berchuck, and Noah D. Kauff
4 Invasion, Metastasis, and Angiogenesis 72
Sharon Romano-Fitzgerald, Alexandre Buckley de Meritens, Angeles Alvarez Secord, and Elise C. Kohn
5 Development and Identification of Tumor Serum Markers 89
Aleksandra Gentry-Maharaj, Ian Jacobs, and Usha Menon
6 Cancer Prevention Strategies 115
Mary B. Daly
7 Preinvasive Disease of the Lower Genital Tract 129
Britt K. Erickson, Kenneth H. Kim, Mark H. Einstein, and Warner K. Huh
SECTION II: DIAGNOSTIC AND THERAPEUTIC MODALITIES
8 Perioperative and Critical Care 151
James J. Burke II, Scott C. Purinton, and Heather MacNew
9 Surgical Principles in Gynecologic Oncology 190
Dennis S. Chi, Robert E. Bristow, and David Cibula
10 Minimally Invasive Surgery in Gynecologic Cancer 210
Denis Querleu, Marie Plante, Yukio Sonoda, Walter Gotlieb, and Eric Leblanc

11 Diagnostic Imaging 244
Evis Sala, Yulia Lakhman, Weining Ma, Harpreet Pannu, Duan Li, Neeta Pandit-Taskar, and Hedvig Hricak
12 Biologic and Physical Principles of Radiation Oncology 284
Beth A. Erickson, Jason Rownd, and Kevin Khater
13 Principles of Chemotherapy in Gynecologic Cancer 342
Michael A. Bookman
14 Pharmacology and Therapeutics in Gynecologic Cancer 370
David S. Alberts, Hilary Calvert, Maria Lluria-Prevatt, Paul H. Sugarbaker, and Bradley J. Monk
15 Immunotherapy of Gynecologic Malignancies 434
Paul J. Sabbatini, Kunle Odunsi, Jacobus Pfisterer, and George Coukos
16 Hormones and Human Malignancies 457
G. Larry Maxwell, Mian M. K. Shahzad, and Laurel W. Rice
17 Clinical Trials Methodology and Biostatistics 481
Mark F. Brady, Jeffrey C. Miecznikowski, and Virginia L. Filiaci
18 Comparative Effectiveness Research in Gynecologic Oncology 501
Laura J. Havrilesky, Shalini L. Kulasingam, Elizabeth L. Jewell, and David E. Cohn
SECTION III: DISEASE SITES
19 Vulva 523
John W. Moroney, Charles Kunos, Edward J. Wilkinson, and Charles F. Levenback
20 Vagina 557
Higinia R. C?denes, Jeanne M. Schilder, and Robert E. Emerson
21 Cervix 598
Marcus E. Randall, Paula M. Fracasso, Takafumi Toita, Sean S. Tedjarati, and Helen Michael
22 Corpus: Epithelial Tumors 661
D. Scott McMeekin, Catherine Yashar, Susana M. Campos, and Richard J. Zaino


23 Corpus: Mesenchymal Tumors 715
Mario M. Leitao Jr, Carmen Tornos, Aaron H. Wolfson, and Roisin O묬earbhaill
24 Epithelial Ovarian Cancer 757
Gini Fleming, Jeffrey Seidman, and Ernst Lengyel
25 Ovarian Germ Cell Tumors 848
Daniela E. Matei, Helen Michael, and David M. Gershenson
26 Ovarian Sex Cord뾖tromal Tumors 866
David M. Gershenson, Sean C. Dowdy, and Robert H. Young
27 Gestational Trophoblastic Disease: Molar Pregnancy and Gestational Trophoblastic Neoplasia 886
Julian C. Schink and John R. Lurain
SECTION IV: SPECIAL MANAGEMENT TOPICS
28 Breast Cancer 909
Robert D. Legare, Don Dizon, Jennifer S. Gass, Trevor Tejada-Berges, Margaret M. Steinhoff, C. James Sung, Susan
Koelliker, Hanan I. Khalil, Jarslow Hepel, William Sikov, and Bachir Sakr


29 Management of Infections in Patients with Gynecologic Malignancy 967
Amar Safdar, Kenneth Rolston, Genevieve L. Bennett, Robert Press, and Donald Armstrong
30 Management of Acute and Chronic Complications of Gynecologic Cancer Treatment 988
Andreas Obermair, Okechukwu A. Ibeanu, Danielle D. Jandial, Deborah K. Armstrong, and Robert E. Bristow
31 Management of Pain 1003
Russell K. Portenoy, Brooke Squillace, and Pauline Lesage
32 Nutrition Support of Patients with Gynecologic Cancer 1025
Mark Schattner and Moshe Shike
33 Quality-of-Life Issues in Gynecologic Oncology 1039
Dana Chase, Lari Wenzel, Richard Penson, Jeanne Carter, and David Cella
34 End-of-Life Care 1052
Susan Zweizig, Sarah Hughes, Lynette Denny, and Joanna Cain
Index 1065