Apoptosis and Cancer Therapy 2 Volumes

Here, an international and highly distinguished team of authors leads readers from the principles of programmed cell
death to the role of apoptosis in cancer development and emerging treatment strategies. Divided into two distinct
parts, the first focuses on apoptosis signaling, covering in depth such topics as mitochondria, effector systems, the
Bcl-2 family, IAPs, survival pathways, tumor suppressor genes, modulators, lysosomes and phagocytosis. The second
section goes on to analyze apoptosis in cancer and cancer therapy, with a detailed look at model systems, molecular
diagnosis, cellular stress, DNA damage and repair, molecular targets and therapeutic aspects. With its strong focus on
recent developments in cancer therapy, this book is aimed at oncologists, molecular and cell biologists, biochemists,
and those working in the pharmaceutical and biotechnological industries.

Table of contents
Volume I. Apoptosis signaling
I.1. Death receptor:
-CD95 signaling
-The TRAIL receptor-ligand system
-TNF-induced cell death
-cFLIP
-Dependence receptors and apoptosis
I.2. Mitochondria:
-Role of mitochondrial proteins in apoptosis
-Omi/HtrA2
-Apoptosis inducing factor (AIF)
I.3. Effector systems:
-Caspases
-Apoptosome
I.4. Bcl-2 family:
-Bcl-2 family proteins
-Bax, Bak and Bid
-Puma/Noxa
I.5. IAPs:
-Inhibitor of apoptosis proteins (IAPs)
-Targeting the survivin pathway
I.6. Survival pathways:
-NFkB
-Pi3K/AKT
-Ras/Raf
I.7. Oncogenes/Tumor suppressor genes:
-P53
-P73
-RB
I.8. Modulators:
-Calcium signaling
I.9. Lysosomes and non-apoptotic pathways
I.10. Phagocytosis/
Clearance:
-Phagocytosis of apoptotic cells
-Clearance of apoptotic cells

Volume II. Apoptosis in cancer and cancer therapy
II.1. Models systems:
-Mouse models
II.2. Molecular diagnosis:
-Molecular imaging in cancer research
-Microarrays
II.3. Cellular stress, DNA damage & repair:
-Stress signaling in cancer
-Hypoxia in cancer
-DNA damage-induced apoptosis
-DNA repair
II.4. Molecular targets and therapeutic aspects:
-Therapeutic Modulation of Apoptosis
-Targeting caspases in cancer
-Cancer therapy by reactivation of the p53 apoptosis pathway
-Small molecule inhibitors of IAPs
-Targeting HSP90
-Targeting the PI3K/Akt pathway
-Ceramide Signaling
-HDAC inhibitors
-Exploiting apoptosis pathways for glioblastoma therapy
-Radiation therapy and apoptosis
-Tumor angiogenesis