Thyroid Cancer

Thyroid Cancer

The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the
United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of
the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the
widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a
number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts
of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new
recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which
have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have
developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In
Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis,
and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a
significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists,
oncologists, nuclear medicine physicians,


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Contents
1 Pathology and Classification of Thyroid Tumors....................... 1
Gretchen E. Galliano and David P. Frishberg
2 Molecular Biology of Thyroid Cancer........................................ 35
Wenwen Chien and H. Phillip Koeffler
3 Thyroid Nodules............................................................................ 45
Glenn D. Braunstein and Wendy Sacks
4 Ultrasound Imaging of Thyroid Cancer..................................... 63
Michelle Melany
5 Fine Needle Aspiration of the Thyroid........................................ 93
Shikha Bose
6 Staging Systems for Differentiated Thyroid Carcinomas......... 109
Ronnie Meiyi Wong and Glenn D. Braunstein
7 Papillary Thyroid Carcinoma...................................................... 133
Wendy Sacks and Glenn D. Braunstein
8 Follicular Thyroid Carcinoma..................................................... 155
Jerome Hershman and Adam Lyko
9 Medullary Thyroid Carcinoma.................................................... 171
Nicole M. Tyer and Run Yu
10 Anaplastic Thyroid Carcinoma................................................... 189
Marina Vaysburd
11 Thyroid Lymphoma...................................................................... 201
Basil Rapoport and Sandra M. McLachlan
12 Surgical Management of Thyroid Cancer.................................. 207
C. Suzanne Cutter, Kenneth W. Adashek, Michel Babajanian,
and Babak Larian
viii Contents
13 Radioactive Iodine Therapy......................................................... 243
Wendy Sacks and Alan D. Waxman
14 External Beam Radiation Therapy in the Treatment
of Differentiated Thyroid Cancers.............................................. 271
C. Michele Burnison
15 Targeted Therapy of Thyroid Cancer......................................... 301
Stephen W. Lim
Index....................................................................................................... 317
http://www.springer.com/978-1-4614-0874-1