Environmental Toxicology-3판(2011.11)

Features
뷖overs the sources, chemistry, and effects of environmental toxicants in animals, plants, and humans
뷙xamines known environmental causes of cancer, the classification of carcinogens, metabolism of chemical carcinogens,
and DNA repair
뷗iscusses environmental fluoride뾦ts occurrences and forms, sources, problems in developing economies, and biochemical
effects
뷧eviews endocrine disruption and mutagenic pollutants
뷞ncludes a new chapter on occupational toxicology written by Dr. Humio Tsunoda and Dr. Masashi Tsunoda
뷨upplies references for further reading and end-of-chapter review questions to test readers?understanding
뷞ncludes more than 100 illustrations


Solutions manual available upon qualifying course adoption


Summary
Human survival depends on the availability of clean air, water, and food and on the welfare of plants and animals.
However, anthropogenic and naturally occurring chemicals can cause adverse effects on living organisms and ecological
processes. Environmental Toxicology: Biological and Health Effects of Pollutants, Third Edition presents fundamental
information on the effects of environmental toxicants on living systems. It focuses on the chemical and biological
characteristics of major pollutants found in the air, water, and soil and relates them to the health and well being of
humans, animals, and plants.


An Indispensable Reference on Air, Soil, & Water Pollutants and Their Impact on Living Systems

Surveying the environmental and health changes that have occurred in recent decades, the book discusses the sources,
metabolism, and damage process of toxicants, and the environmental, biological, and nutritional factors that may
influence toxicity. It looks at natural defense systems, including the mechanisms for detoxification뾱uch as endogenous
antioxidants and free radical scavenging enzymes뾬n a cellular level.


The text examines the major toxicants: EPA criteria air pollutants, environmental fluoride, volatile organic compounds
(VOCs), environmental metals and metalloids involved in soil and water pollution, and pesticides and related material
such as PCBs and dioxins. It then addresses their relationship with endocrine disruption and environmental cancer. This
comprehensive approach offers insight into the interaction of various chemical agents with DNA.


Fully revised and expanded, the third edition of this popular book includes new and updated material as well as a new
chapter on occupational toxicology. Appendices cover the process of ecological risk assessment, carcinogens, and PCB
nomenclature. Based on research from more than 35 years of teaching environmental toxicology and related courses, this
textbook is a useful resource for students, professionals, and researchers interested in the effects of pollutants on
living systems.

What뭩 New in This Edition

뷒 new chapter on occupational toxicology, covering indoor air quality, chemicals in the workplace, nanoparticle
exposure, and more
뷒n updated chapter on environmental changes and health, including significant environmental changes that have occurred
since the last edition
뷒n updated chapter on environmental cancer, including changes in death rates of respiratory cancers
뷣ew material on the importance of nitrous oxide (N2O) in stratospheric ozone layer depletion
뷒n expanded discussion of environmental disasters


Table of Contents
Introduction
Study of Environmental Toxicology
Importance of Environmental Toxicology as an Area of Science
Introduction to this Book

Environmental Changes and Health
Our Changing Environment
Air Pollution
Indoor Air Pollution
Water Pollution
Soil Pollution
The Changing Diseases
Review Questions
References

Occurrence of Toxicants
Introduction
Visible Smoke or Smog
Offensive Odors
Agricultural Damage
Intoxication of Animals
Injuries to Humans
Chronic and Acute Effects
References

Toxic Action of Pollutants
Introduction
Effects on Plants
Mammalian Organisms
Mechanism of Toxic Action
Review Questions
References

Factors Affecting Xenobiotic Action
Introduction
Physiological Properties
Dose or Concentration
Duration and Mode of Exposure
Environmental Factors
Interaction
Biological Factors
Nutritional Factors
Review Questions
References

Biotransformation: Metabolism of Xenobiotics
Introduction
Types of Biotransformation
Mechanism of Biotransformation
Characteristics of Biotransformation
Consequence of Biotransformation
Factors Affecting Biotransformation
Characteristics of the Cytochrome P450s
Review Questions
References

Responses to Environmental Toxicants
Introduction
Responses of Plants
Responses of Humans and Animals
Review Questions
References

Air Pollution: Inorganic Gases
Introduction
Sulfur Dioxide
Nitrogen Dioxide
Ozone
Carbon Monoxide
Review Questions
References

Air Pollution: Particulate Matter
Introduction
Characteristics of Particulate Matter
Formation of Particulates
Health Effects
Silica
Beryllium
Asbestos
Lead
Review Questions
References

Environmental Fluoride
Introduction
Occurrence and Forms of Fluoride
Industrial Sources of Fluoride Pollution
Effects on Plants
Effects on Animals
Effects on Humans
Biochemical Effect of Fluoride
Nutrition and Fluoride Toxicity
Review Questions
References

Volatile Organic Compounds
Introduction
Sources
Petroleum Hydrocarbons
Polycyclic Aromatic Hydrocarbons
Review Questions
References

Soil and Water Pollution: Environmental Metals and Metalloids
Introduction
Lead
Cadmium
Mercury
Nickel
Arsenic
Review Questions
References

Pesticides and Related Materials
Introduction
Insecticides
Herbicides
Polychlorinated Biphenyls
Polybrominated Biphenyls
Dioxin
Review Questions
References

Occupational Toxicology
Introduction
Changing Workplace Environment
Threshold Limit Values
Biological Exposure Indices
Respiratory Toxicity
Other Occupational Diseases Caused by Toxic Substances
Recent Chemicals of Concern
Review Questions
References

Endocrine Disruption
Introduction
Review of Hormonal Function
Characteristics of Endocrine Disrupters
Mode of Action
Examples of Endocrine Disruption
Hormonal Cancers
Testing Estrogenicity
Review Questions
References

Mutagenic Pollutants
Introduction
Types of Mutation
Effects of Mutation
Induction of Mutation
Review Questions
References

Environmental Cancer
Introduction
Causes of Cancer
Three Stages in the Development of Cancer
Metastasis
Classification of Carcinogens
Metabolism of Chemical Carcinogens
Respiratory Cancer Death Rates
DNA Repair
Review Questions
References

Appendix 1: Ecological Risk Assessment
Appendix 2: 11th Report on Carcinogens
Appendix 3: List of Cigarette Smoke Carcinogens
Appendix 4: Polychlorinated Biphenyl (PCB) Nomenclature

Index